Statistical modeling and analyses of a base-specific Salmonella mutagenicity assay
Statistical features of a base-specific Salmonella mutagenicity assay are considered in detail, following up on a previous report comparing responses of base-specific Salmonella (Ames II™) strains with those of traditional tester strains. In addition to using different Salmonella strains, the new pr...
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| Veröffentlicht in: | Mutation research 2000-04, Vol.467 (1), p.11-19 |
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| container_title | Mutation research |
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| creator | Piegorsch, Walter W Simmons, Susan J Margolin, Barry H Zeiger, Errol Gidrol, Xavier M Gee, Pauline |
| description | Statistical features of a base-specific
Salmonella mutagenicity assay are considered in detail, following up on a previous report comparing responses of base-specific
Salmonella (Ames II™) strains with those of traditional tester strains. In addition to using different
Salmonella strains, the new procedure also differs in that it is performed as a microwell fluctuation test, as opposed to the standard plate or preincubation test. This report describes the statistical modeling of data obtained from the use of these new strains in the microwell test procedure. We emphasize how to assess any significant interactions between replicate cultures and exposure doses, and how to identify a significant increase in the mutagenic response to a series of concentrations of a test substance. |
| doi_str_mv | 10.1016/S1383-5718(00)00019-X |
| format | Article |
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Salmonella (Ames II™) strains with those of traditional tester strains. In addition to using different
Salmonella strains, the new procedure also differs in that it is performed as a microwell fluctuation test, as opposed to the standard plate or preincubation test. This report describes the statistical modeling of data obtained from the use of these new strains in the microwell test procedure. We emphasize how to assess any significant interactions between replicate cultures and exposure doses, and how to identify a significant increase in the mutagenic response to a series of concentrations of a test substance.</description><identifier>ISSN: 1383-5718</identifier><identifier>ISSN: 0027-5107</identifier><identifier>EISSN: 1879-3592</identifier><identifier>DOI: 10.1016/S1383-5718(00)00019-X</identifier><identifier>PMID: 10771267</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Ames II strains ; Analysis of Variance ; Benzene Derivatives - pharmacology ; Biological and medical sciences ; Chemical mutagenesis ; Complementary log–log link function ; Culture-by-dose interaction ; Fluctuation test ; Generalized linear model ; Genotype ; His− mutant tester strains ; Many-to-one testing ; Medical sciences ; Models, Statistical ; Multiple comparisons with a control ; Mutagenicity Tests - statistics & numerical data ; Mutagens - pharmacology ; Mutation ; Nitrofurantoin - pharmacology ; Salmonella ; Salmonella typhimurium ; Salmonella typhimurium - classification ; Salmonella typhimurium - genetics ; Serology ; Statistical methods ; Toxicology</subject><ispartof>Mutation research, 2000-04, Vol.467 (1), p.11-19</ispartof><rights>2000 Elsevier Science B.V.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-3dc200828a52db6bfd8e695f82574db7fa18e207aad7c4fc5ad9573007922dca3</citedby><cites>FETCH-LOGICAL-c421t-3dc200828a52db6bfd8e695f82574db7fa18e207aad7c4fc5ad9573007922dca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1383-5718(00)00019-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1318340$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10771267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Piegorsch, Walter W</creatorcontrib><creatorcontrib>Simmons, Susan J</creatorcontrib><creatorcontrib>Margolin, Barry H</creatorcontrib><creatorcontrib>Zeiger, Errol</creatorcontrib><creatorcontrib>Gidrol, Xavier M</creatorcontrib><creatorcontrib>Gee, Pauline</creatorcontrib><title>Statistical modeling and analyses of a base-specific Salmonella mutagenicity assay</title><title>Mutation research</title><addtitle>Mutat Res</addtitle><description>Statistical features of a base-specific
Salmonella mutagenicity assay are considered in detail, following up on a previous report comparing responses of base-specific
Salmonella (Ames II™) strains with those of traditional tester strains. In addition to using different
Salmonella strains, the new procedure also differs in that it is performed as a microwell fluctuation test, as opposed to the standard plate or preincubation test. This report describes the statistical modeling of data obtained from the use of these new strains in the microwell test procedure. We emphasize how to assess any significant interactions between replicate cultures and exposure doses, and how to identify a significant increase in the mutagenic response to a series of concentrations of a test substance.</description><subject>Ames II strains</subject><subject>Analysis of Variance</subject><subject>Benzene Derivatives - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Chemical mutagenesis</subject><subject>Complementary log–log link function</subject><subject>Culture-by-dose interaction</subject><subject>Fluctuation test</subject><subject>Generalized linear model</subject><subject>Genotype</subject><subject>His− mutant tester strains</subject><subject>Many-to-one testing</subject><subject>Medical sciences</subject><subject>Models, Statistical</subject><subject>Multiple comparisons with a control</subject><subject>Mutagenicity Tests - statistics & numerical data</subject><subject>Mutagens - pharmacology</subject><subject>Mutation</subject><subject>Nitrofurantoin - pharmacology</subject><subject>Salmonella</subject><subject>Salmonella typhimurium</subject><subject>Salmonella typhimurium - classification</subject><subject>Salmonella typhimurium - genetics</subject><subject>Serology</subject><subject>Statistical methods</subject><subject>Toxicology</subject><issn>1383-5718</issn><issn>0027-5107</issn><issn>1879-3592</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LHEEQhpugxI_kJ0TmICE5jKnu3t7uOYlIjIIguAl4a2q6q6VlPjZTs8L--8y6K-bmoag6PFX18gjxRcKZBDn_sZDa6dJY6b4BfAcAWZUPH8ShdLYqtanU3jS_IgfiiPkJQIEG91EcSLBWqrk9FPeLEcfMYw7YFG0fqcndY4FdnAqbNRMXfSqwqJGp5CWFnHIoFti0fUdNg0W7GvGRuhzyuC6QGdefxH7Chunzrh-LP1c_f19el7d3v24uL27LMFNyLHUMCsAph0bFel6n6GhemeSUsbNY24TSkQKLGG2YpWAwVsZqAFspFQPqY_F1e3c59H9XxKNvM4dNqI76FXtpjbQWqgk0WzAMPfNAyS-H3OKw9hL8RqZ_kek3pjyAf5HpH6a9k92DVd1S_G9ra28CTncA8uQvDdiFzG-clk7PYMLOtxhNNp4zDZ5Dpi5QzAOF0cc-v5PkHyrnkZ8</recordid><startdate>20000413</startdate><enddate>20000413</enddate><creator>Piegorsch, Walter W</creator><creator>Simmons, Susan J</creator><creator>Margolin, Barry H</creator><creator>Zeiger, Errol</creator><creator>Gidrol, Xavier M</creator><creator>Gee, Pauline</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20000413</creationdate><title>Statistical modeling and analyses of a base-specific Salmonella mutagenicity assay</title><author>Piegorsch, Walter W ; Simmons, Susan J ; Margolin, Barry H ; Zeiger, Errol ; Gidrol, Xavier M ; Gee, Pauline</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-3dc200828a52db6bfd8e695f82574db7fa18e207aad7c4fc5ad9573007922dca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Ames II strains</topic><topic>Analysis of Variance</topic><topic>Benzene Derivatives - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Chemical mutagenesis</topic><topic>Complementary log–log link function</topic><topic>Culture-by-dose interaction</topic><topic>Fluctuation test</topic><topic>Generalized linear model</topic><topic>Genotype</topic><topic>His− mutant tester strains</topic><topic>Many-to-one testing</topic><topic>Medical sciences</topic><topic>Models, Statistical</topic><topic>Multiple comparisons with a control</topic><topic>Mutagenicity Tests - statistics & numerical data</topic><topic>Mutagens - pharmacology</topic><topic>Mutation</topic><topic>Nitrofurantoin - pharmacology</topic><topic>Salmonella</topic><topic>Salmonella typhimurium</topic><topic>Salmonella typhimurium - classification</topic><topic>Salmonella typhimurium - genetics</topic><topic>Serology</topic><topic>Statistical methods</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Piegorsch, Walter W</creatorcontrib><creatorcontrib>Simmons, Susan J</creatorcontrib><creatorcontrib>Margolin, Barry H</creatorcontrib><creatorcontrib>Zeiger, Errol</creatorcontrib><creatorcontrib>Gidrol, Xavier M</creatorcontrib><creatorcontrib>Gee, Pauline</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Mutation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Piegorsch, Walter W</au><au>Simmons, Susan J</au><au>Margolin, Barry H</au><au>Zeiger, Errol</au><au>Gidrol, Xavier M</au><au>Gee, Pauline</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Statistical modeling and analyses of a base-specific Salmonella mutagenicity assay</atitle><jtitle>Mutation research</jtitle><addtitle>Mutat Res</addtitle><date>2000-04-13</date><risdate>2000</risdate><volume>467</volume><issue>1</issue><spage>11</spage><epage>19</epage><pages>11-19</pages><issn>1383-5718</issn><issn>0027-5107</issn><eissn>1879-3592</eissn><abstract>Statistical features of a base-specific
Salmonella mutagenicity assay are considered in detail, following up on a previous report comparing responses of base-specific
Salmonella (Ames II™) strains with those of traditional tester strains. In addition to using different
Salmonella strains, the new procedure also differs in that it is performed as a microwell fluctuation test, as opposed to the standard plate or preincubation test. This report describes the statistical modeling of data obtained from the use of these new strains in the microwell test procedure. We emphasize how to assess any significant interactions between replicate cultures and exposure doses, and how to identify a significant increase in the mutagenic response to a series of concentrations of a test substance.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>10771267</pmid><doi>10.1016/S1383-5718(00)00019-X</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Ames II strains Analysis of Variance Benzene Derivatives - pharmacology Biological and medical sciences Chemical mutagenesis Complementary log–log link function Culture-by-dose interaction Fluctuation test Generalized linear model Genotype His− mutant tester strains Many-to-one testing Medical sciences Models, Statistical Multiple comparisons with a control Mutagenicity Tests - statistics & numerical data Mutagens - pharmacology Mutation Nitrofurantoin - pharmacology Salmonella Salmonella typhimurium Salmonella typhimurium - classification Salmonella typhimurium - genetics Serology Statistical methods Toxicology |
| title | Statistical modeling and analyses of a base-specific Salmonella mutagenicity assay |
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