Gestational Diabetes Mellitus Can Be Prevented by Lifestyle Intervention: The Finnish Gestational Diabetes Prevention Study (RADIEL): A Randomized Controlled Trial
To assess whether gestational diabetes mellitus (GDM) can be prevented by a moderate lifestyle intervention in pregnant women who are at high risk for the disease. Two hundred ninety-three women with a history of GDM and/or a prepregnancy BMI of ≥30 kg/m(2) were enrolled in the study at
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| Veröffentlicht in: | Diabetes care 2016-01, Vol.39 (1), p.24-30 |
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| creator | Koivusalo, Saila B Rönö, Kristiina Klemetti, Miira M Roine, Risto P Lindström, Jaana Erkkola, Maijaliisa Kaaja, Risto J Pöyhönen-Alho, Maritta Tiitinen, Aila Huvinen, Emilia Andersson, Sture Laivuori, Hannele Valkama, Anita Meinilä, Jelena Kautiainen, Hannu Eriksson, Johan G Stach-Lempinen, Beata |
| description | To assess whether gestational diabetes mellitus (GDM) can be prevented by a moderate lifestyle intervention in pregnant women who are at high risk for the disease.
Two hundred ninety-three women with a history of GDM and/or a prepregnancy BMI of ≥30 kg/m(2) were enrolled in the study at |
| doi_str_mv | 10.2337/dc15-0511 |
| format | Article |
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Two hundred ninety-three women with a history of GDM and/or a prepregnancy BMI of ≥30 kg/m(2) were enrolled in the study at <20 weeks of gestation and were randomly allocated to the intervention group (n = 155) or the control group (n = 138). Each subject in the intervention group received individualized counseling on diet, physical activity, and weight control from trained study nurses, and had one group meeting with a dietitian. The control group received standard antenatal care. The diagnosis of GDM was based on a 75-g, 2-h oral glucose tolerance test at 24-28 weeks of gestation.
A total of 269 women were included in the analyses. The incidence of GDM was 13.9% in the intervention group and 21.6% in the control group ([95% CI 0.40-0.98%]; P = 0.044, after adjustment for age, prepregnancy BMI, previous GDM status, and the number of weeks of gestation). Gestational weight gain was lower in the intervention group (-0.58 kg [95% CI -1.12 to -0.04 kg]; adjusted P = 0.037). Women in the intervention group increased their leisure time physical activity more and improved their dietary quality compared with women in the control group.
A moderate individualized lifestyle intervention reduced the incidence of GDM by 39% in high-risk pregnant women. These findings may have major health consequences for both the mother and the child.</description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/dc15-0511</identifier><identifier>PMID: 26223239</identifier><identifier>CODEN: DICAD2</identifier><language>eng</language><publisher>United States: American Diabetes Association</publisher><subject>Adult ; Body Mass Index ; Counseling ; Diabetes ; Diabetes, Gestational - epidemiology ; Diabetes, Gestational - prevention & control ; Diet ; Female ; Finland - epidemiology ; Glucose ; Glucose Tolerance Test ; Humans ; Intervention ; Life Style ; Lifestyles ; Obesity - prevention & control ; Pregnancy ; Prenatal Care ; Primary Prevention ; Risk assessment ; Weight control ; Weight Gain ; Young Adult</subject><ispartof>Diabetes care, 2016-01, Vol.39 (1), p.24-30</ispartof><rights>2016 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.</rights><rights>Copyright American Diabetes Association Jan 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26223239$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koivusalo, Saila B</creatorcontrib><creatorcontrib>Rönö, Kristiina</creatorcontrib><creatorcontrib>Klemetti, Miira M</creatorcontrib><creatorcontrib>Roine, Risto P</creatorcontrib><creatorcontrib>Lindström, Jaana</creatorcontrib><creatorcontrib>Erkkola, Maijaliisa</creatorcontrib><creatorcontrib>Kaaja, Risto J</creatorcontrib><creatorcontrib>Pöyhönen-Alho, Maritta</creatorcontrib><creatorcontrib>Tiitinen, Aila</creatorcontrib><creatorcontrib>Huvinen, Emilia</creatorcontrib><creatorcontrib>Andersson, Sture</creatorcontrib><creatorcontrib>Laivuori, Hannele</creatorcontrib><creatorcontrib>Valkama, Anita</creatorcontrib><creatorcontrib>Meinilä, Jelena</creatorcontrib><creatorcontrib>Kautiainen, Hannu</creatorcontrib><creatorcontrib>Eriksson, Johan G</creatorcontrib><creatorcontrib>Stach-Lempinen, Beata</creatorcontrib><title>Gestational Diabetes Mellitus Can Be Prevented by Lifestyle Intervention: The Finnish Gestational Diabetes Prevention Study (RADIEL): A Randomized Controlled Trial</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description>To assess whether gestational diabetes mellitus (GDM) can be prevented by a moderate lifestyle intervention in pregnant women who are at high risk for the disease.
Two hundred ninety-three women with a history of GDM and/or a prepregnancy BMI of ≥30 kg/m(2) were enrolled in the study at <20 weeks of gestation and were randomly allocated to the intervention group (n = 155) or the control group (n = 138). Each subject in the intervention group received individualized counseling on diet, physical activity, and weight control from trained study nurses, and had one group meeting with a dietitian. The control group received standard antenatal care. The diagnosis of GDM was based on a 75-g, 2-h oral glucose tolerance test at 24-28 weeks of gestation.
A total of 269 women were included in the analyses. The incidence of GDM was 13.9% in the intervention group and 21.6% in the control group ([95% CI 0.40-0.98%]; P = 0.044, after adjustment for age, prepregnancy BMI, previous GDM status, and the number of weeks of gestation). Gestational weight gain was lower in the intervention group (-0.58 kg [95% CI -1.12 to -0.04 kg]; adjusted P = 0.037). Women in the intervention group increased their leisure time physical activity more and improved their dietary quality compared with women in the control group.
A moderate individualized lifestyle intervention reduced the incidence of GDM by 39% in high-risk pregnant women. These findings may have major health consequences for both the mother and the child.</description><subject>Adult</subject><subject>Body Mass Index</subject><subject>Counseling</subject><subject>Diabetes</subject><subject>Diabetes, Gestational - epidemiology</subject><subject>Diabetes, Gestational - prevention & control</subject><subject>Diet</subject><subject>Female</subject><subject>Finland - epidemiology</subject><subject>Glucose</subject><subject>Glucose Tolerance Test</subject><subject>Humans</subject><subject>Intervention</subject><subject>Life Style</subject><subject>Lifestyles</subject><subject>Obesity - prevention & control</subject><subject>Pregnancy</subject><subject>Prenatal Care</subject><subject>Primary Prevention</subject><subject>Risk assessment</subject><subject>Weight control</subject><subject>Weight Gain</subject><subject>Young Adult</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkMtOwzAQRS0EoqWw4AeQJTZlEfAjduLuSl9UKgKVsq5ceyKM0qTECVL5HX4UF8oGsZrRzJk7uhehc0quGefJjTVURERQeoDaVHERCRGnh6hNaKwioRRroRPvXwkhcZymx6jFJGOccdVGnxPwta5dWegcD51eQQ0e30Oeu7rxeKALfAv4sYJ3KGqweLXFM5eFm20OeBpG1W4Rznt48QJ47IrC-Rf8r-peJUzxU93YLe7O-8PpaHbVw30814Ut1-4j_BiURV2VeR7aReV0foqOMp17ONvXDnoejxaDu2j2MJkO-rNoE6zUkRJCGm4zmlhCuVTGEM2ShBltgNNUpEZTokwsgRAtRQbGAmE2EwkoS2LgHdT90d1U5VsTHCzXzpsQhS6gbPySJoLKhBIpA3r5B30tmyq4_aYSwiVRO-piTzWrNdjlpnJrXW2Xv_HzL-Ydhtw</recordid><startdate>201601</startdate><enddate>201601</enddate><creator>Koivusalo, Saila B</creator><creator>Rönö, Kristiina</creator><creator>Klemetti, Miira M</creator><creator>Roine, Risto P</creator><creator>Lindström, Jaana</creator><creator>Erkkola, Maijaliisa</creator><creator>Kaaja, Risto J</creator><creator>Pöyhönen-Alho, Maritta</creator><creator>Tiitinen, Aila</creator><creator>Huvinen, Emilia</creator><creator>Andersson, Sture</creator><creator>Laivuori, Hannele</creator><creator>Valkama, Anita</creator><creator>Meinilä, Jelena</creator><creator>Kautiainen, Hannu</creator><creator>Eriksson, Johan G</creator><creator>Stach-Lempinen, Beata</creator><general>American Diabetes Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201601</creationdate><title>Gestational Diabetes Mellitus Can Be Prevented by Lifestyle Intervention: The Finnish Gestational Diabetes Prevention Study (RADIEL): A Randomized Controlled Trial</title><author>Koivusalo, Saila B ; 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Two hundred ninety-three women with a history of GDM and/or a prepregnancy BMI of ≥30 kg/m(2) were enrolled in the study at <20 weeks of gestation and were randomly allocated to the intervention group (n = 155) or the control group (n = 138). Each subject in the intervention group received individualized counseling on diet, physical activity, and weight control from trained study nurses, and had one group meeting with a dietitian. The control group received standard antenatal care. The diagnosis of GDM was based on a 75-g, 2-h oral glucose tolerance test at 24-28 weeks of gestation.
A total of 269 women were included in the analyses. The incidence of GDM was 13.9% in the intervention group and 21.6% in the control group ([95% CI 0.40-0.98%]; P = 0.044, after adjustment for age, prepregnancy BMI, previous GDM status, and the number of weeks of gestation). Gestational weight gain was lower in the intervention group (-0.58 kg [95% CI -1.12 to -0.04 kg]; adjusted P = 0.037). Women in the intervention group increased their leisure time physical activity more and improved their dietary quality compared with women in the control group.
A moderate individualized lifestyle intervention reduced the incidence of GDM by 39% in high-risk pregnant women. These findings may have major health consequences for both the mother and the child.</abstract><cop>United States</cop><pub>American Diabetes Association</pub><pmid>26223239</pmid><doi>10.2337/dc15-0511</doi><tpages>7</tpages></addata></record> |
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| ispartof | Diabetes care, 2016-01, Vol.39 (1), p.24-30 |
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| subjects | Adult Body Mass Index Counseling Diabetes Diabetes, Gestational - epidemiology Diabetes, Gestational - prevention & control Diet Female Finland - epidemiology Glucose Glucose Tolerance Test Humans Intervention Life Style Lifestyles Obesity - prevention & control Pregnancy Prenatal Care Primary Prevention Risk assessment Weight control Weight Gain Young Adult |
| title | Gestational Diabetes Mellitus Can Be Prevented by Lifestyle Intervention: The Finnish Gestational Diabetes Prevention Study (RADIEL): A Randomized Controlled Trial |
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