Epigenetic stimulation of polyketide production in Chaetomium cancroideum by an NAD(+)-dependent HDAC inhibitor

Exposure of the fungus Chaetomium cancroideum to an NAD(+)-dependent HDAC inhibitor, nicotinamide, enhanced the production of aromatic and branched aliphatic polyketides, which allowed us to isolate new secondary metabolites, chaetophenol G and cancrolides A and B. Their structures were determined u...

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Veröffentlicht in:	Organic & biomolecular chemistry 2016-01, Vol.14 (2), p.646-651
Hauptverfasser:	Asai, Teigo, Morita, Shuntaro, Taniguchi, Tohru, Monde, Kenji, Oshima, Yoshiteru
Format:	Artikel
Sprache:	eng
Schlagworte:	Chaetomium - drug effects Chaetomium - metabolism HCT116 Cells Histone Deacetylase Inhibitors - chemical synthesis Histone Deacetylase Inhibitors - chemistry Histone Deacetylase Inhibitors - pharmacology Histone Deacetylases - metabolism Humans Molecular Conformation NAD - metabolism NAD - pharmacology Polyketides - chemistry Polyketides - metabolism Structure-Activity Relationship
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