Lipopolysaccharide and the Trichothecene Vomitoxin (Deoxynivalenol) Synergistically Induce Apoptosis in Murine Lymphoid Organs

Human exposure to Gram-negative bacterial lipopolysaccharide (LPS) is common and may have an important influence on chemical toxicity. LPS has been shown previously to enhance synergistically the toxicity of trichothecene mycotoxins. Because either of these toxin groups alone characteristically targ...

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Veröffentlicht in:	Toxicological sciences 2000-02, Vol.53 (2), p.253-263
Hauptverfasser:	Zhou, Hui-Ren, Harkema, Jack R., Hotchkiss, Jon A., Yan, Ding, Roth, Robert A., Pestka, James J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptosis Apoptosis - drug effects Biological and medical sciences bone marrow Bone Marrow Cells - drug effects Bone Marrow Cells - pathology Cell Separation deoxynivalenol DNA Fragmentation - drug effects Drug Synergism endotoxin Flow Cytometry Fundamental and applied biological sciences. Psychology immunotoxicity In Situ Nick-End Labeling lipopolysaccharide Lipopolysaccharides - pharmacology Lymphoid Tissue - drug effects Lymphoid Tissue - pathology Male Mice Mice, Inbred Strains Microbiology Mycology mycotoxin Pathogenicity, host-agent relations, miscellaneous strains, epidemiology Peyer's patch Peyer's Patches - drug effects Peyer's Patches - pathology programmed cell death protein synthesis inhibition Salmonella typhimurium spleen Spleen - drug effects Spleen - pathology thymus Thymus Gland - drug effects Thymus Gland - pathology trichothecene trichothecenes Trichothecenes - toxicity vomitoxin
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