N-Acetyltransferase genetics and their role in predisposition to aromatic and heterocyclic amine-induced carcinogenesis

N-Acetyltransferases (EC 2.3.1.5) are important in both the activation and deactivation of aromatic and heterocyclic amine carcinogens. Two N-acetyltransferase isozymes (NAT1 and NAT2) encoded by NAT1 and NAT2, respectively, have been identified. Both NAT1 and NAT2 exhibit genetic polymorphisms, and...

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Veröffentlicht in:	Toxicology letters 2000-03, Vol.112 (1-3), p.349-356
1. Verfasser:	Hein, David W
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Acetylation polymorphisms Acetyltransferases - genetics Acetyltransferases - physiology Alleles aromatic amines Breast cancer Breast Neoplasms - etiology Breast Neoplasms - genetics Carcinogens - antagonists & inhibitors Carcinogens - toxicity Colorectal cancer Colorectal Neoplasms - genetics Female Genotype heterocyclic amines Heterocyclic Compounds - antagonists & inhibitors Heterocyclic Compounds - toxicity Humans Hydrocarbons, Aromatic - antagonists & inhibitors Hydrocarbons, Aromatic - toxicity Molecular Epidemiology N-Acetyltransferase Phenotype Polymorphism, Genetic Postmenopause
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