Bergapten induces metabolic reprogramming in breast cancer cells

Alterations in cellular metabolism are among the most consistent hallmarks of cancer. Herein, after a comprehensive metabolic phenotype characterization of MCF7 and ZR75 breast cancer cells, we investigated the activity of bergapten (Bg), a plant-derived compound, against breast cancer. The study of...

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Veröffentlicht in:	Oncology reports 2016-01, Vol.35 (1), p.568-576
Hauptverfasser:	SANTORO, MARTA, GUIDO, CARMELA, DE AMICIS, FRANCESCA, SISCI, DIEGO, CIONE, ERIKA, VINCENZA, DOLCE, DONÀ, ADA, PANNO, MARIA LUISA, AQUILA, SAVERIA
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Bioenergetics Breast cancer Breast Neoplasms - metabolism cancer metabolism Cancer therapies Cell cycle Cell growth Cell Line, Tumor Cell metabolism Dehydrogenases Development and progression Energy Metabolism - drug effects Fatty acids Female Gene expression Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Genotype & phenotype glucose-6-phosphate dehydrogenase activity Glucosephosphate Dehydrogenase - metabolism Glycolysis - drug effects Health aspects Humans Kinases lactate dehydrogenase Lipase - metabolism lipase activity MCF-7 Cells Medical prognosis Metabolism Metabolites Methoxsalen - analogs & derivatives Methoxsalen - pharmacology methoxypsoralen Observations OXPHOS Physiological aspects Plant products Rodents Studies Tumors
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