Overexpression of lysine-specific demethylase 1 promotes androgen-independent transition of human prostate cancer LNCaP cells through activation of the AR signaling pathway and suppression of the p53 signaling pathway

Lysine-specific demethylase 1 (LSD1) is the first defined histone demethylase, and was found to be closely correlated with the development and progression of various types of cancers, including prostate cancer (PCa). Previous research suggests that LSD1 is closely related with cell proliferation, an...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncology reports 2016-01, Vol.35 (1), p.584-592
Hauptverfasser:	LI, XUECHAO, LI, TAO, CHEN, DEHONG, ZHANG, PENG, SONG, YARONG, ZHU, HONGXUE, XIAO, YAJUN, XING, YIFEI
Format:	Artikel
Sprache:	eng
Schlagworte:	androgen receptor androgen-independent transition Androgens Androgens - metabolism Antibiotics Apoptosis Biotechnology Cell Cycle Cell growth Cell Line, Tumor Cell Proliferation Development and progression Flow cytometry Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Health aspects Histone Demethylases - genetics Histone Demethylases - metabolism human prostate cancer Humans LNCaP cells lysine-specific demethylase 1 Male Mutation Oxidoreductases p53 Phenols Plasmids Properties Prostate cancer Prostatic Neoplasms - metabolism Proteins Receptors, Androgen - genetics Receptors, Androgen - metabolism Signal Transduction Transcription factors Tumor proteins Tumor Suppressor Protein p53 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!