Proteomic and Lipidomic Analysis of Nanoparticle Corona upon Contact with Lung Surfactant Reveals Differences in Protein, but Not Lipid Composition

Pulmonary surfactant (PS) constitutes the first line of host defense in the deep lung. Because of its high content of phospholipids and surfactant specific proteins, the interaction of inhaled nanoparticles (NPs) with the pulmonary surfactant layer is likely to form a corona that is different to the...

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Veröffentlicht in:	ACS nano 2015-12, Vol.9 (12), p.11872-11885
Hauptverfasser:	Raesch, Simon Sebastian, Tenzer, Stefan, Storck, Wiebke, Rurainski, Alexander, Selzer, Dominik, Ruge, Christian Arnold, Perez-Gil, Jesus, Schaefer, Ulrich Friedrich, Lehr, Claus-Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Bronchoalveolar Lavage Fluid - chemistry Nanoparticles - chemistry Nanoparticles - metabolism Phospholipids - analysis Phospholipids - chemistry Phospholipids - metabolism Protein Corona - analysis Protein Corona - chemistry Protein Corona - metabolism Proteins - analysis Proteins - chemistry Proteins - metabolism Pulmonary Surfactants - chemistry Pulmonary Surfactants - metabolism
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