Intracisternal PYY inhibits gastric lesions induced by ethanol in rats: role of PYY-preferring receptors?
We previously reported that intracisternal (i.c.) injection of peptide YY (PYY) and low doses of thyrotropin-releasing hormone (TRH) or TRH analog, RX 77368, increased the resistance of the gastric mucosa to ethanol injury through vagal pathways in rats. The gastroprotective effect of i.c. injection...
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| Veröffentlicht in: | Brain research 2000-01, Vol.854 (1), p.30-34 |
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| description | We previously reported that intracisternal (i.c.) injection of peptide YY (PYY) and low doses of thyrotropin-releasing hormone (TRH) or TRH analog, RX 77368, increased the resistance of the gastric mucosa to ethanol injury through vagal pathways in rats. The gastroprotective effect of i.c. injection of PYY/neuropeptide NPY (NPY) agonists with differential in vitro affinity to the Y receptor subtypes was examined in urethane-anesthetized rats. Intragastric administration of ethanol (45%, 5 ml/kg) results in mucosal lesions covering 23±2% of the gastric corpus in 1 h. PYY (500 ng, i.c.) significantly reduced ethanol-induced gastric lesions by 52%. [Pro
34]PYY (PYY-preferring/Y
1/Y
5/Y
4 subtypes) injected i.c. at 50, 100, 200 or 500 ng, reduced dose dependently gastric lesions to 15.4±2.2%, 11.4±3.1%, 8.6±2.9% and 5.4±2.2%, respectively. PYY
3–36, (Y
2/Y
4 subtypes), [Leu
31, Pro
34]NPY (Y
1/Y
5), NPY (Y
3/Y
1/Y
5/Y
2) and pancreatic polypeptide (PP, Y
4) injected i.c. at 500 ng did not influence significantly ethanol-induced gastric lesions. Combined i.c. injection of RX 77368 (1 ng) and Pro
34PYY (25 ng), at sub-threshold doses given singly, reduced ethanol-induced gastric injury to 12.9±2.3% while RX 77368 (1 ng) plus PYY
3–36 (500 ng) or [Leu
31, Pro
34]NPY (25 ng) had no effect. These findings indicate that i.c. PYY-induced gastric protection against 45% ethanol is mediated by a Y receptor subtype which bears similarity with the putative PYY-preferring receptor and distinct from the currently defined Y
1/Y
5; in addition, there is a synergistic interaction between activation of this PYY-preferring receptor and i.c. TRH to increase the resistance of the gastric mucosa to injury caused by 45% ethanol. |
| doi_str_mv | 10.1016/S0006-8993(99)02293-3 |
| format | Article |
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34]PYY (PYY-preferring/Y
1/Y
5/Y
4 subtypes) injected i.c. at 50, 100, 200 or 500 ng, reduced dose dependently gastric lesions to 15.4±2.2%, 11.4±3.1%, 8.6±2.9% and 5.4±2.2%, respectively. PYY
3–36, (Y
2/Y
4 subtypes), [Leu
31, Pro
34]NPY (Y
1/Y
5), NPY (Y
3/Y
1/Y
5/Y
2) and pancreatic polypeptide (PP, Y
4) injected i.c. at 500 ng did not influence significantly ethanol-induced gastric lesions. Combined i.c. injection of RX 77368 (1 ng) and Pro
34PYY (25 ng), at sub-threshold doses given singly, reduced ethanol-induced gastric injury to 12.9±2.3% while RX 77368 (1 ng) plus PYY
3–36 (500 ng) or [Leu
31, Pro
34]NPY (25 ng) had no effect. These findings indicate that i.c. PYY-induced gastric protection against 45% ethanol is mediated by a Y receptor subtype which bears similarity with the putative PYY-preferring receptor and distinct from the currently defined Y
1/Y
5; in addition, there is a synergistic interaction between activation of this PYY-preferring receptor and i.c. TRH to increase the resistance of the gastric mucosa to injury caused by 45% ethanol.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(99)02293-3</identifier><identifier>PMID: 10784103</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>[Pro 34]PYY ; Alcoholism and acute alcohol poisoning ; Animals ; Biological and medical sciences ; Cisterna Magna - metabolism ; Cisterna Magna - physiopathology ; Dose-Response Relationship, Drug ; Drug Synergism ; Ethanol ; Ethanol - pharmacology ; Gastric lesion ; Gastric Mucosa - drug effects ; Gastric Mucosa - pathology ; Gastric protection ; Injections ; Male ; Medical sciences ; Peptide YY - pharmacology ; Pyrrolidonecarboxylic Acid - analogs & derivatives ; PYY ; Rats ; Rats, Sprague-Dawley ; Receptors, Gastrointestinal Hormone - physiology ; RX 77368 ; Stomach Diseases - chemically induced ; Stomach Diseases - physiopathology ; Stomach Diseases - prevention & control ; Thyrotropin-Releasing Hormone - analogs & derivatives ; Thyrotropin-Releasing Hormone - pharmacology ; Toxicology</subject><ispartof>Brain research, 2000-01, Vol.854 (1), p.30-34</ispartof><rights>2000 Elsevier Science B.V.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-dc4fe75aec15c468fc3cbb73f4513d3542a69dd5a681023500629b9811ef87e53</citedby><cites>FETCH-LOGICAL-c421t-dc4fe75aec15c468fc3cbb73f4513d3542a69dd5a681023500629b9811ef87e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006899399022933$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1249417$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10784103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawakubo, Keishi</creatorcontrib><creatorcontrib>Yang, Hong</creatorcontrib><creatorcontrib>Taché, Yvette</creatorcontrib><title>Intracisternal PYY inhibits gastric lesions induced by ethanol in rats: role of PYY-preferring receptors?</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>We previously reported that intracisternal (i.c.) injection of peptide YY (PYY) and low doses of thyrotropin-releasing hormone (TRH) or TRH analog, RX 77368, increased the resistance of the gastric mucosa to ethanol injury through vagal pathways in rats. The gastroprotective effect of i.c. injection of PYY/neuropeptide NPY (NPY) agonists with differential in vitro affinity to the Y receptor subtypes was examined in urethane-anesthetized rats. Intragastric administration of ethanol (45%, 5 ml/kg) results in mucosal lesions covering 23±2% of the gastric corpus in 1 h. PYY (500 ng, i.c.) significantly reduced ethanol-induced gastric lesions by 52%. [Pro
34]PYY (PYY-preferring/Y
1/Y
5/Y
4 subtypes) injected i.c. at 50, 100, 200 or 500 ng, reduced dose dependently gastric lesions to 15.4±2.2%, 11.4±3.1%, 8.6±2.9% and 5.4±2.2%, respectively. PYY
3–36, (Y
2/Y
4 subtypes), [Leu
31, Pro
34]NPY (Y
1/Y
5), NPY (Y
3/Y
1/Y
5/Y
2) and pancreatic polypeptide (PP, Y
4) injected i.c. at 500 ng did not influence significantly ethanol-induced gastric lesions. Combined i.c. injection of RX 77368 (1 ng) and Pro
34PYY (25 ng), at sub-threshold doses given singly, reduced ethanol-induced gastric injury to 12.9±2.3% while RX 77368 (1 ng) plus PYY
3–36 (500 ng) or [Leu
31, Pro
34]NPY (25 ng) had no effect. These findings indicate that i.c. PYY-induced gastric protection against 45% ethanol is mediated by a Y receptor subtype which bears similarity with the putative PYY-preferring receptor and distinct from the currently defined Y
1/Y
5; in addition, there is a synergistic interaction between activation of this PYY-preferring receptor and i.c. TRH to increase the resistance of the gastric mucosa to injury caused by 45% ethanol.</description><subject>[Pro 34]PYY</subject><subject>Alcoholism and acute alcohol poisoning</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cisterna Magna - metabolism</subject><subject>Cisterna Magna - physiopathology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Synergism</subject><subject>Ethanol</subject><subject>Ethanol - pharmacology</subject><subject>Gastric lesion</subject><subject>Gastric Mucosa - drug effects</subject><subject>Gastric Mucosa - pathology</subject><subject>Gastric protection</subject><subject>Injections</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Peptide YY - pharmacology</subject><subject>Pyrrolidonecarboxylic Acid - analogs & derivatives</subject><subject>PYY</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Gastrointestinal Hormone - physiology</subject><subject>RX 77368</subject><subject>Stomach Diseases - chemically induced</subject><subject>Stomach Diseases - physiopathology</subject><subject>Stomach Diseases - prevention & control</subject><subject>Thyrotropin-Releasing Hormone - analogs & derivatives</subject><subject>Thyrotropin-Releasing Hormone - pharmacology</subject><subject>Toxicology</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LXDEUhkOp1PHjJ7RkUUQXt-brfsTNIKJVEFpoXbgKubnnasqdZMzJFPz3ZpyhuusqnOQ5b855CPnM2TfOeHP6izHWVJ3W8ljrEyaElpX8QGa8a0XVCMU-ktk_ZJfsIf4ppZSafSK7nLWd4kzOiL8JOVnnMUMKdqI_7--pD4--9xnpg8WcvKMToI8By8OwcjDQ_plCfrQhTuWKJpvxjKY4AY3jOqBaJhghJR8eaAIHyxwTzg_IzmgnhMPtuU_uri5_X1xXtz--31yc31ZOCZ6rwakR2tqC47VTTTc66fq-laOquRxkrYRt9DDUtuk4E7IuKwrd645zGLsWarlPjja5yxSfVoDZLDw6mCYbIK7Q8LYEqVYWsN6ALkXEMrJZJr-w6dlwZtaOzatjsxZotDavjs2678v2g1W_gOFd10ZqAb5uAYvOTmOyoQh-44TSircFm28wKDb-ekgGnYdQBPtiLZsh-v9M8gKwdZj2</recordid><startdate>20000131</startdate><enddate>20000131</enddate><creator>Kawakubo, Keishi</creator><creator>Yang, Hong</creator><creator>Taché, Yvette</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>20000131</creationdate><title>Intracisternal PYY inhibits gastric lesions induced by ethanol in rats: role of PYY-preferring receptors?</title><author>Kawakubo, Keishi ; Yang, Hong ; Taché, Yvette</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-dc4fe75aec15c468fc3cbb73f4513d3542a69dd5a681023500629b9811ef87e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>[Pro 34]PYY</topic><topic>Alcoholism and acute alcohol poisoning</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cisterna Magna - metabolism</topic><topic>Cisterna Magna - physiopathology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Synergism</topic><topic>Ethanol</topic><topic>Ethanol - pharmacology</topic><topic>Gastric lesion</topic><topic>Gastric Mucosa - drug effects</topic><topic>Gastric Mucosa - pathology</topic><topic>Gastric protection</topic><topic>Injections</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Peptide YY - pharmacology</topic><topic>Pyrrolidonecarboxylic Acid - analogs & derivatives</topic><topic>PYY</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Gastrointestinal Hormone - physiology</topic><topic>RX 77368</topic><topic>Stomach Diseases - chemically induced</topic><topic>Stomach Diseases - physiopathology</topic><topic>Stomach Diseases - prevention & control</topic><topic>Thyrotropin-Releasing Hormone - analogs & derivatives</topic><topic>Thyrotropin-Releasing Hormone - pharmacology</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawakubo, Keishi</creatorcontrib><creatorcontrib>Yang, Hong</creatorcontrib><creatorcontrib>Taché, Yvette</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawakubo, Keishi</au><au>Yang, Hong</au><au>Taché, Yvette</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intracisternal PYY inhibits gastric lesions induced by ethanol in rats: role of PYY-preferring receptors?</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2000-01-31</date><risdate>2000</risdate><volume>854</volume><issue>1</issue><spage>30</spage><epage>34</epage><pages>30-34</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>We previously reported that intracisternal (i.c.) injection of peptide YY (PYY) and low doses of thyrotropin-releasing hormone (TRH) or TRH analog, RX 77368, increased the resistance of the gastric mucosa to ethanol injury through vagal pathways in rats. The gastroprotective effect of i.c. injection of PYY/neuropeptide NPY (NPY) agonists with differential in vitro affinity to the Y receptor subtypes was examined in urethane-anesthetized rats. Intragastric administration of ethanol (45%, 5 ml/kg) results in mucosal lesions covering 23±2% of the gastric corpus in 1 h. PYY (500 ng, i.c.) significantly reduced ethanol-induced gastric lesions by 52%. [Pro
34]PYY (PYY-preferring/Y
1/Y
5/Y
4 subtypes) injected i.c. at 50, 100, 200 or 500 ng, reduced dose dependently gastric lesions to 15.4±2.2%, 11.4±3.1%, 8.6±2.9% and 5.4±2.2%, respectively. PYY
3–36, (Y
2/Y
4 subtypes), [Leu
31, Pro
34]NPY (Y
1/Y
5), NPY (Y
3/Y
1/Y
5/Y
2) and pancreatic polypeptide (PP, Y
4) injected i.c. at 500 ng did not influence significantly ethanol-induced gastric lesions. Combined i.c. injection of RX 77368 (1 ng) and Pro
34PYY (25 ng), at sub-threshold doses given singly, reduced ethanol-induced gastric injury to 12.9±2.3% while RX 77368 (1 ng) plus PYY
3–36 (500 ng) or [Leu
31, Pro
34]NPY (25 ng) had no effect. These findings indicate that i.c. PYY-induced gastric protection against 45% ethanol is mediated by a Y receptor subtype which bears similarity with the putative PYY-preferring receptor and distinct from the currently defined Y
1/Y
5; in addition, there is a synergistic interaction between activation of this PYY-preferring receptor and i.c. TRH to increase the resistance of the gastric mucosa to injury caused by 45% ethanol.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>10784103</pmid><doi>10.1016/S0006-8993(99)02293-3</doi><tpages>5</tpages></addata></record> |
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| subjects | [Pro 34]PYY Alcoholism and acute alcohol poisoning Animals Biological and medical sciences Cisterna Magna - metabolism Cisterna Magna - physiopathology Dose-Response Relationship, Drug Drug Synergism Ethanol Ethanol - pharmacology Gastric lesion Gastric Mucosa - drug effects Gastric Mucosa - pathology Gastric protection Injections Male Medical sciences Peptide YY - pharmacology Pyrrolidonecarboxylic Acid - analogs & derivatives PYY Rats Rats, Sprague-Dawley Receptors, Gastrointestinal Hormone - physiology RX 77368 Stomach Diseases - chemically induced Stomach Diseases - physiopathology Stomach Diseases - prevention & control Thyrotropin-Releasing Hormone - analogs & derivatives Thyrotropin-Releasing Hormone - pharmacology Toxicology |
| title | Intracisternal PYY inhibits gastric lesions induced by ethanol in rats: role of PYY-preferring receptors? |
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