Adjunctive Maintenance Lamotrigine for Pediatric Bipolar I Disorder: A Placebo-Controlled, Randomized Withdrawal Study

Objective This study aimed to compare the efficacy of lamotrigine versus placebo in 10- to 17-year-olds with bipolar I disorder (BP-I) who were receiving conventional bipolar disorder treatment. Method In this randomized withdrawal trial, patients with BP-I of at least moderate severity received lam...

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Veröffentlicht in:	Journal of the American Academy of Child and Adolescent Psychiatry 2015-12, Vol.54 (12), p.1020-1031.e3
Hauptverfasser:	Findling, Robert L., MD, MBA, Chang, Kiki, MD, Robb, Adelaide, MD, Foster, Vicki J., MSPH, Horrigan, Joseph, MD, Krishen, Alok, MS, Wamil, Art, MD, PhD, Kraus, John E., MD, PhD, DelBello, Melissa, MD, MS
Format:	Artikel
Sprache:	eng
Schlagworte:	adjunctive therapy Adolescent Adolescents Antimanic Agents - administration & dosage Antimanic Agents - adverse effects Bipolar disorder Bipolar Disorder - drug therapy bipolar I disorder Child Child & adolescent psychiatry Clinical trials Critical incidents Double-Blind Method Efficacy Female Humans Kaplan-Meier Estimate Lamotrigine Male Mood Motivation Patients pediatric Pediatrics Placebo effect Proportional Hazards Models Psychiatric Status Rating Scales Psychiatry Quality of Life Severity Stabilization Statistical analysis Suicide Treatment Outcome Triazines - administration & dosage Triazines - adverse effects United States
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