Comparison of ultrasonography features and malignancy rate of toxic and nontoxic autonomous nodules: a preliminary study
Objective When a scintigraphically autonomous nodule does not produce thyroid hormones enough to suppress serum thyrotrophin, it is generally defined as nontoxic autonomous nodule. In this study, we aimed to compare clinical and ultrasonographical (US) features and cytological and histopathological...
Gespeichert in:
| Veröffentlicht in: | Annals of nuclear medicine 2015-12, Vol.29 (10), p.883-889 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 889 |
|---|---|
| container_issue | 10 |
| container_start_page | 883 |
| container_title | Annals of nuclear medicine |
| container_volume | 29 |
| creator | Dirikoc, Ahmet Polat, Sefika Burcak Kandemir, Zuhal Aydin, Cevdet Ozdemir, Didem Dellal, Fatma Dilek Ersoy, Reyhan Cakir, Bekir |
| description | Objective
When a scintigraphically autonomous nodule does not produce thyroid hormones enough to suppress serum thyrotrophin, it is generally defined as nontoxic autonomous nodule. In this study, we aimed to compare clinical and ultrasonographical (US) features and cytological and histopathological results of toxic and nontoxic autonomous nodules.
Methods
Patients who underwent thyroidectomy and were evaluated with technetium-99m-pertechnetate scintigraphy preoperatively in our institution between May 2008 and December 2014 were identified from medical records. Among these, treatment naïve patients with scintigraphically autonomous thyroid nodules were chosen and classified into toxic (hyperthyroid) and nontoxic (euthyroid) groups. The demographic data, preoperative US features of the nodules, fine needle aspiration biopsy and histopathological results were analyzed.
Results
There were 170 (89.0 %) patients with toxic and 21 (11.0 %) patients with nontoxic autonomous nodules. A total of 258 scintigraphically autonomous nodules were analyzed among which 227 were clinically functional (toxic) and 31 were clinically euthyroid (nontoxic). Echogenity, texture, marginal irregularity, presence of halo and macrocalcification were similar in toxic and nontoxic autonomous nodules. Toxic autonomous nodules were significantly bigger and had a significantly higher rate of microcalcification compared to nontoxic ones (
p
= 0.001 and
p
= 0.025, respectively). There was no significant difference in terms of cytological diagnosis between toxic and nontoxic autonomous nodules (
p
= 0.052). Atypia of undetermined significance/follicular lesion of undetermined significance cytology was significantly higher in nontoxic group (
p
= 0.01). 20 (8.8 %) of 227 toxic and 2 (6.5 %) of 31 nontoxic autonomous nodules were malignant (
p
= 0.59). Considering all nodules regardless of the thyroid function, 8.5 % of autonomous nodules was malignant.
Conclusion
US features and malignancy potential of nontoxic autonomous nodules resemble toxic autonomous nodules. Lower diameter suggests that they can represent a preliminary stage of toxic ones and have potential of toxicity when get bigger in size. There is still a considerable risk of malignancy risk in autonomous nodules whether toxic or not. |
| doi_str_mv | 10.1007/s12149-015-1018-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1751228624</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3897197941</sourcerecordid><originalsourceid>FETCH-LOGICAL-c499t-a95ecfc01d5306527379b14917f137dffab74ab29adb276e2af55a63cce6d583</originalsourceid><addsrcrecordid>eNp1kUuLFDEUhYMoTtvOD3AjATduysk7Ve6k8QUDs5l9uJVK2hqqkjKpwNS_Nz3dighmk8f9zsm9HITeUPKBEqJvMmVUdA2hsqGEts32DO1oq0SjBOfP0Y50VDSatvoKvcr5gRDWypa9RFdMMc24aHfo8RDnBdKYY8DR4zKtCeo5HhMsPzbsHawluYwhDHiGaTwGCHbDCVZ34tf4ONqnYojhcilr1c-x5Po2lMnljxjwktw0zmOAtOG8lmF7jV54mLK7vux7dP_l8_3hW3N79_X74dNtY0XXrQ100llvCR0kJ0oyzXXX16Gp9pTrwXvotYCedTD0TCvHwEsJilvr1CBbvkfvz7ZLij-Ly6uZx2zdNEFwtUVDtaSMtYqJir77B32IJYXaXKVEp4jmde0RPVM2xZyT82ZJ41zHMpSYUyrmnIqpqZhTKmarmrcX59LPbvij-B1DBdgZyLUUji799fV_XX8BBJWa1g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1749607333</pqid></control><display><type>article</type><title>Comparison of ultrasonography features and malignancy rate of toxic and nontoxic autonomous nodules: a preliminary study</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Dirikoc, Ahmet ; Polat, Sefika Burcak ; Kandemir, Zuhal ; Aydin, Cevdet ; Ozdemir, Didem ; Dellal, Fatma Dilek ; Ersoy, Reyhan ; Cakir, Bekir</creator><creatorcontrib>Dirikoc, Ahmet ; Polat, Sefika Burcak ; Kandemir, Zuhal ; Aydin, Cevdet ; Ozdemir, Didem ; Dellal, Fatma Dilek ; Ersoy, Reyhan ; Cakir, Bekir</creatorcontrib><description>Objective
When a scintigraphically autonomous nodule does not produce thyroid hormones enough to suppress serum thyrotrophin, it is generally defined as nontoxic autonomous nodule. In this study, we aimed to compare clinical and ultrasonographical (US) features and cytological and histopathological results of toxic and nontoxic autonomous nodules.
Methods
Patients who underwent thyroidectomy and were evaluated with technetium-99m-pertechnetate scintigraphy preoperatively in our institution between May 2008 and December 2014 were identified from medical records. Among these, treatment naïve patients with scintigraphically autonomous thyroid nodules were chosen and classified into toxic (hyperthyroid) and nontoxic (euthyroid) groups. The demographic data, preoperative US features of the nodules, fine needle aspiration biopsy and histopathological results were analyzed.
Results
There were 170 (89.0 %) patients with toxic and 21 (11.0 %) patients with nontoxic autonomous nodules. A total of 258 scintigraphically autonomous nodules were analyzed among which 227 were clinically functional (toxic) and 31 were clinically euthyroid (nontoxic). Echogenity, texture, marginal irregularity, presence of halo and macrocalcification were similar in toxic and nontoxic autonomous nodules. Toxic autonomous nodules were significantly bigger and had a significantly higher rate of microcalcification compared to nontoxic ones (
p
= 0.001 and
p
= 0.025, respectively). There was no significant difference in terms of cytological diagnosis between toxic and nontoxic autonomous nodules (
p
= 0.052). Atypia of undetermined significance/follicular lesion of undetermined significance cytology was significantly higher in nontoxic group (
p
= 0.01). 20 (8.8 %) of 227 toxic and 2 (6.5 %) of 31 nontoxic autonomous nodules were malignant (
p
= 0.59). Considering all nodules regardless of the thyroid function, 8.5 % of autonomous nodules was malignant.
Conclusion
US features and malignancy potential of nontoxic autonomous nodules resemble toxic autonomous nodules. Lower diameter suggests that they can represent a preliminary stage of toxic ones and have potential of toxicity when get bigger in size. There is still a considerable risk of malignancy risk in autonomous nodules whether toxic or not.</description><identifier>ISSN: 0914-7187</identifier><identifier>EISSN: 1864-6433</identifier><identifier>DOI: 10.1007/s12149-015-1018-y</identifier><identifier>PMID: 26272348</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Adult ; Aged ; Diagnosis, Differential ; Female ; Humans ; Imaging ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Nuclear Medicine ; Original Article ; Radiology ; Radionuclide Imaging ; Thyroid Hormones - metabolism ; Thyroid Nodule - diagnostic imaging ; Thyroid Nodule - metabolism ; Thyroid Nodule - pathology ; Ultrasonography ; Young Adult</subject><ispartof>Annals of nuclear medicine, 2015-12, Vol.29 (10), p.883-889</ispartof><rights>The Japanese Society of Nuclear Medicine 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-a95ecfc01d5306527379b14917f137dffab74ab29adb276e2af55a63cce6d583</citedby><cites>FETCH-LOGICAL-c499t-a95ecfc01d5306527379b14917f137dffab74ab29adb276e2af55a63cce6d583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12149-015-1018-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12149-015-1018-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26272348$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dirikoc, Ahmet</creatorcontrib><creatorcontrib>Polat, Sefika Burcak</creatorcontrib><creatorcontrib>Kandemir, Zuhal</creatorcontrib><creatorcontrib>Aydin, Cevdet</creatorcontrib><creatorcontrib>Ozdemir, Didem</creatorcontrib><creatorcontrib>Dellal, Fatma Dilek</creatorcontrib><creatorcontrib>Ersoy, Reyhan</creatorcontrib><creatorcontrib>Cakir, Bekir</creatorcontrib><title>Comparison of ultrasonography features and malignancy rate of toxic and nontoxic autonomous nodules: a preliminary study</title><title>Annals of nuclear medicine</title><addtitle>Ann Nucl Med</addtitle><addtitle>Ann Nucl Med</addtitle><description>Objective
When a scintigraphically autonomous nodule does not produce thyroid hormones enough to suppress serum thyrotrophin, it is generally defined as nontoxic autonomous nodule. In this study, we aimed to compare clinical and ultrasonographical (US) features and cytological and histopathological results of toxic and nontoxic autonomous nodules.
Methods
Patients who underwent thyroidectomy and were evaluated with technetium-99m-pertechnetate scintigraphy preoperatively in our institution between May 2008 and December 2014 were identified from medical records. Among these, treatment naïve patients with scintigraphically autonomous thyroid nodules were chosen and classified into toxic (hyperthyroid) and nontoxic (euthyroid) groups. The demographic data, preoperative US features of the nodules, fine needle aspiration biopsy and histopathological results were analyzed.
Results
There were 170 (89.0 %) patients with toxic and 21 (11.0 %) patients with nontoxic autonomous nodules. A total of 258 scintigraphically autonomous nodules were analyzed among which 227 were clinically functional (toxic) and 31 were clinically euthyroid (nontoxic). Echogenity, texture, marginal irregularity, presence of halo and macrocalcification were similar in toxic and nontoxic autonomous nodules. Toxic autonomous nodules were significantly bigger and had a significantly higher rate of microcalcification compared to nontoxic ones (
p
= 0.001 and
p
= 0.025, respectively). There was no significant difference in terms of cytological diagnosis between toxic and nontoxic autonomous nodules (
p
= 0.052). Atypia of undetermined significance/follicular lesion of undetermined significance cytology was significantly higher in nontoxic group (
p
= 0.01). 20 (8.8 %) of 227 toxic and 2 (6.5 %) of 31 nontoxic autonomous nodules were malignant (
p
= 0.59). Considering all nodules regardless of the thyroid function, 8.5 % of autonomous nodules was malignant.
Conclusion
US features and malignancy potential of nontoxic autonomous nodules resemble toxic autonomous nodules. Lower diameter suggests that they can represent a preliminary stage of toxic ones and have potential of toxicity when get bigger in size. There is still a considerable risk of malignancy risk in autonomous nodules whether toxic or not.</description><subject>Adult</subject><subject>Aged</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Humans</subject><subject>Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nuclear Medicine</subject><subject>Original Article</subject><subject>Radiology</subject><subject>Radionuclide Imaging</subject><subject>Thyroid Hormones - metabolism</subject><subject>Thyroid Nodule - diagnostic imaging</subject><subject>Thyroid Nodule - metabolism</subject><subject>Thyroid Nodule - pathology</subject><subject>Ultrasonography</subject><subject>Young Adult</subject><issn>0914-7187</issn><issn>1864-6433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kUuLFDEUhYMoTtvOD3AjATduysk7Ve6k8QUDs5l9uJVK2hqqkjKpwNS_Nz3dighmk8f9zsm9HITeUPKBEqJvMmVUdA2hsqGEts32DO1oq0SjBOfP0Y50VDSatvoKvcr5gRDWypa9RFdMMc24aHfo8RDnBdKYY8DR4zKtCeo5HhMsPzbsHawluYwhDHiGaTwGCHbDCVZ34tf4ONqnYojhcilr1c-x5Po2lMnljxjwktw0zmOAtOG8lmF7jV54mLK7vux7dP_l8_3hW3N79_X74dNtY0XXrQ100llvCR0kJ0oyzXXX16Gp9pTrwXvotYCedTD0TCvHwEsJilvr1CBbvkfvz7ZLij-Ly6uZx2zdNEFwtUVDtaSMtYqJir77B32IJYXaXKVEp4jmde0RPVM2xZyT82ZJ41zHMpSYUyrmnIqpqZhTKmarmrcX59LPbvij-B1DBdgZyLUUji799fV_XX8BBJWa1g</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Dirikoc, Ahmet</creator><creator>Polat, Sefika Burcak</creator><creator>Kandemir, Zuhal</creator><creator>Aydin, Cevdet</creator><creator>Ozdemir, Didem</creator><creator>Dellal, Fatma Dilek</creator><creator>Ersoy, Reyhan</creator><creator>Cakir, Bekir</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20151201</creationdate><title>Comparison of ultrasonography features and malignancy rate of toxic and nontoxic autonomous nodules: a preliminary study</title><author>Dirikoc, Ahmet ; Polat, Sefika Burcak ; Kandemir, Zuhal ; Aydin, Cevdet ; Ozdemir, Didem ; Dellal, Fatma Dilek ; Ersoy, Reyhan ; Cakir, Bekir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-a95ecfc01d5306527379b14917f137dffab74ab29adb276e2af55a63cce6d583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Humans</topic><topic>Imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nuclear Medicine</topic><topic>Original Article</topic><topic>Radiology</topic><topic>Radionuclide Imaging</topic><topic>Thyroid Hormones - metabolism</topic><topic>Thyroid Nodule - diagnostic imaging</topic><topic>Thyroid Nodule - metabolism</topic><topic>Thyroid Nodule - pathology</topic><topic>Ultrasonography</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dirikoc, Ahmet</creatorcontrib><creatorcontrib>Polat, Sefika Burcak</creatorcontrib><creatorcontrib>Kandemir, Zuhal</creatorcontrib><creatorcontrib>Aydin, Cevdet</creatorcontrib><creatorcontrib>Ozdemir, Didem</creatorcontrib><creatorcontrib>Dellal, Fatma Dilek</creatorcontrib><creatorcontrib>Ersoy, Reyhan</creatorcontrib><creatorcontrib>Cakir, Bekir</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Annals of nuclear medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dirikoc, Ahmet</au><au>Polat, Sefika Burcak</au><au>Kandemir, Zuhal</au><au>Aydin, Cevdet</au><au>Ozdemir, Didem</au><au>Dellal, Fatma Dilek</au><au>Ersoy, Reyhan</au><au>Cakir, Bekir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of ultrasonography features and malignancy rate of toxic and nontoxic autonomous nodules: a preliminary study</atitle><jtitle>Annals of nuclear medicine</jtitle><stitle>Ann Nucl Med</stitle><addtitle>Ann Nucl Med</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>29</volume><issue>10</issue><spage>883</spage><epage>889</epage><pages>883-889</pages><issn>0914-7187</issn><eissn>1864-6433</eissn><abstract>Objective
When a scintigraphically autonomous nodule does not produce thyroid hormones enough to suppress serum thyrotrophin, it is generally defined as nontoxic autonomous nodule. In this study, we aimed to compare clinical and ultrasonographical (US) features and cytological and histopathological results of toxic and nontoxic autonomous nodules.
Methods
Patients who underwent thyroidectomy and were evaluated with technetium-99m-pertechnetate scintigraphy preoperatively in our institution between May 2008 and December 2014 were identified from medical records. Among these, treatment naïve patients with scintigraphically autonomous thyroid nodules were chosen and classified into toxic (hyperthyroid) and nontoxic (euthyroid) groups. The demographic data, preoperative US features of the nodules, fine needle aspiration biopsy and histopathological results were analyzed.
Results
There were 170 (89.0 %) patients with toxic and 21 (11.0 %) patients with nontoxic autonomous nodules. A total of 258 scintigraphically autonomous nodules were analyzed among which 227 were clinically functional (toxic) and 31 were clinically euthyroid (nontoxic). Echogenity, texture, marginal irregularity, presence of halo and macrocalcification were similar in toxic and nontoxic autonomous nodules. Toxic autonomous nodules were significantly bigger and had a significantly higher rate of microcalcification compared to nontoxic ones (
p
= 0.001 and
p
= 0.025, respectively). There was no significant difference in terms of cytological diagnosis between toxic and nontoxic autonomous nodules (
p
= 0.052). Atypia of undetermined significance/follicular lesion of undetermined significance cytology was significantly higher in nontoxic group (
p
= 0.01). 20 (8.8 %) of 227 toxic and 2 (6.5 %) of 31 nontoxic autonomous nodules were malignant (
p
= 0.59). Considering all nodules regardless of the thyroid function, 8.5 % of autonomous nodules was malignant.
Conclusion
US features and malignancy potential of nontoxic autonomous nodules resemble toxic autonomous nodules. Lower diameter suggests that they can represent a preliminary stage of toxic ones and have potential of toxicity when get bigger in size. There is still a considerable risk of malignancy risk in autonomous nodules whether toxic or not.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>26272348</pmid><doi>10.1007/s12149-015-1018-y</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0914-7187 |
| ispartof | Annals of nuclear medicine, 2015-12, Vol.29 (10), p.883-889 |
| issn | 0914-7187 1864-6433 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1751228624 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Aged Diagnosis, Differential Female Humans Imaging Male Medicine Medicine & Public Health Middle Aged Nuclear Medicine Original Article Radiology Radionuclide Imaging Thyroid Hormones - metabolism Thyroid Nodule - diagnostic imaging Thyroid Nodule - metabolism Thyroid Nodule - pathology Ultrasonography Young Adult |
| title | Comparison of ultrasonography features and malignancy rate of toxic and nontoxic autonomous nodules: a preliminary study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T09%3A31%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20ultrasonography%20features%20and%20malignancy%20rate%20of%20toxic%20and%20nontoxic%20autonomous%20nodules:%20a%20preliminary%20study&rft.jtitle=Annals%20of%20nuclear%20medicine&rft.au=Dirikoc,%20Ahmet&rft.date=2015-12-01&rft.volume=29&rft.issue=10&rft.spage=883&rft.epage=889&rft.pages=883-889&rft.issn=0914-7187&rft.eissn=1864-6433&rft_id=info:doi/10.1007/s12149-015-1018-y&rft_dat=%3Cproquest_cross%3E3897197941%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1749607333&rft_id=info:pmid/26272348&rfr_iscdi=true |