Leucovorin, fluorouracil, and oxaliplatin plus bevacizumab versus S-1 and oxaliplatin plus bevacizumab in patients with metastatic colorectal cancer (SOFT): an open-label, non-inferiority, randomised phase 3 trial

Summary Background Studies done in Asia have shown that a regimen of S-1 plus oxaliplatin (SOX) has promising efficacy and safety in patients with metastatic colorectal cancer. We aimed to establish whether SOX plus bevacizumab is non-inferior to mFOLFOX6 (modified regimen of leucovorin, fluorouraci...

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Veröffentlicht in:	The lancet oncology 2013-12, Vol.14 (13), p.1278-1286
Hauptverfasser:	Yamada, Yasuhide, Dr, Takahari, Daisuke, MD, Matsumoto, Hiroshi, MD, Baba, Hideo, Prof, Nakamura, Masato, MD, Yoshida, Kazuhiro, Prof, Yoshida, Motoki, MD, Iwamoto, Shigeyoshi, MD, Shimada, Ken, MD, Komatsu, Yoshito, MD, Sasaki, Yasutsuna, Prof, Satoh, Taroh, MD, Takahashi, Keiichi, MD, Mishima, Hideyuki, Prof, Muro, Kei, MD, Watanabe, Masahiko, Prof, Sakata, Yuh, MD, Morita, Satoshi, Prof, Shimada, Yasuhiro, MD, Sugihara, Kenichi, Prof
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antibodies, Monoclonal, Humanized - administration & dosage Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bevacizumab Cancer therapies Chemotherapy Chemotherapy, Adjuvant Clinical trials Colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Creatinine Diarrhea Disease-Free Survival Drug Administration Schedule Drug Combinations Drug dosages Ethics Female Fluorouracil - administration & dosage Hematology, Oncology and Palliative Medicine Humans Infusions, Intravenous Japan Kaplan-Meier Estimate Leucovorin - administration & dosage Male Metastasis Middle Aged Neoplasm Staging Neutrophils Organoplatinum Compounds - administration & dosage Oxonic Acid - administration & dosage Tegafur - administration & dosage Toxicity Treatment Outcome
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