Longitudinal analysis of retinal nerve fiber layer and ganglion cell–inner plexiform layer thickness in ethambutol-induced optic neuropathy
Purpose The aim of the study was to evaluate longitudinal analysis of peripapillary retinal nerve fiber layer (RNFL) and perifoveal ganglion cell–inner plexiform layer (GCIPL) thickness in patients being treated with ethambutol (EMB). Methods This prospective longitudinal cohort study enrolled 37 pa...
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| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 2015-12, Vol.253 (12), p.2293-2299 |
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| creator | Han, Jinu Byun, Min Kwang Lee, Junwon Han, So Young Lee, Jong Bok Han, Sueng-Han |
| description | Purpose
The aim of the study was to evaluate longitudinal analysis of peripapillary retinal nerve fiber layer (RNFL) and perifoveal ganglion cell–inner plexiform layer (GCIPL) thickness in patients being treated with ethambutol (EMB).
Methods
This prospective longitudinal cohort study enrolled 37 patients who were treated with EMB for pulmonary tuberculosis. Best-corrected visual acuity, color vision test, automated perimetry, fundus photography, and RNFL and GCIPL thickness were measured at baseline and at 4 and 6 months after the start of EMB treatment, using Cirrus optical coherence tomography.
Results
Among 37 patients, EMB-induced optic neuropathy occurred in one patient (2.7 %). In this patient, thickening of the RFNL and thinning of the GCIPL were noted at the onset of symptoms. After discontinuation of EMB, RNFL and GCIPL thickness progressively normalized. Changes in RNFL and GCIPL thickness were not statistically significant in the 36 patients who did not exhibit EMB-induced optic neuropathy-related symptoms during follow-up (all
P
values > 0.05).
Conclusions
Thickening of the peripapillary RNFL and thinning of the perifoveal GCIPL is an effective quantitative and early marker for diagnosis of EMB-induced optic neuropathy. |
| doi_str_mv | 10.1007/s00417-015-3150-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1751217287</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1735326233</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-ff55b0105875e9fd353b9419d5315438dc2885140d85acc4e8e20878e3cbec233</originalsourceid><addsrcrecordid>eNqNkc-KFDEQxoMo7rj6AF4k4GUvcfN3kjnK4qow4GWFvTXppHoma3fSJt2Lc9sX2JNv6JOY2RlFBMFLFVR-9X2kPoReMvqGUarPC6WSaUKZIoIpSswjtGBSKKIpv36MFlRzRozg1yfoWSk3tOJCsafohC-FlFrQBbpfp7gJ0-xDtD22texKKDh1OMP0MIuQbwF3oYWMe7ur1UaPNzZu-pAidtD3P-6-h1g5PPbwLXQpD0dy2gb3JUIpOEQM09YO7TylnoToZwcep3EKrjrMOY122u6eoyed7Qu8OPZT9Pny3dXFB7L-9P7jxds1cVKriXSdUi1lVBmtYNV5oUS7kmzlVT2DFMY7boxiknqjrHMSDHBqtAHhWnBciFN0dtAdc_o6Q5maIZT9T2yENJeGacU409zo_0CrO19W0Yq-_gu9SXOuN3yg5JIqIUyl2IFyOZWSoWvGHAabdw2jzT7W5hBrU2Nt9rE2-51XR-W5HcD_3viVYwX4ASj1KW4g_2H9T9Wf0VCv6Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1734605338</pqid></control><display><type>article</type><title>Longitudinal analysis of retinal nerve fiber layer and ganglion cell–inner plexiform layer thickness in ethambutol-induced optic neuropathy</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Han, Jinu ; Byun, Min Kwang ; Lee, Junwon ; Han, So Young ; Lee, Jong Bok ; Han, Sueng-Han</creator><creatorcontrib>Han, Jinu ; Byun, Min Kwang ; Lee, Junwon ; Han, So Young ; Lee, Jong Bok ; Han, Sueng-Han</creatorcontrib><description>Purpose
The aim of the study was to evaluate longitudinal analysis of peripapillary retinal nerve fiber layer (RNFL) and perifoveal ganglion cell–inner plexiform layer (GCIPL) thickness in patients being treated with ethambutol (EMB).
Methods
This prospective longitudinal cohort study enrolled 37 patients who were treated with EMB for pulmonary tuberculosis. Best-corrected visual acuity, color vision test, automated perimetry, fundus photography, and RNFL and GCIPL thickness were measured at baseline and at 4 and 6 months after the start of EMB treatment, using Cirrus optical coherence tomography.
Results
Among 37 patients, EMB-induced optic neuropathy occurred in one patient (2.7 %). In this patient, thickening of the RFNL and thinning of the GCIPL were noted at the onset of symptoms. After discontinuation of EMB, RNFL and GCIPL thickness progressively normalized. Changes in RNFL and GCIPL thickness were not statistically significant in the 36 patients who did not exhibit EMB-induced optic neuropathy-related symptoms during follow-up (all
P
values > 0.05).
Conclusions
Thickening of the peripapillary RNFL and thinning of the perifoveal GCIPL is an effective quantitative and early marker for diagnosis of EMB-induced optic neuropathy.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-015-3150-8</identifier><identifier>PMID: 26344730</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Antitubercular Agents - adverse effects ; Color Vision - physiology ; Ethambutol - adverse effects ; Female ; Follow-Up Studies ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Mycobacterium ; Nerve Fibers - pathology ; Neurophthalmology ; Ophthalmology ; Optic Nerve Diseases - chemically induced ; Optic Nerve Diseases - diagnosis ; Prospective Studies ; Retinal Ganglion Cells - pathology ; Tomography, Optical Coherence ; Tuberculosis, Pulmonary - drug therapy ; Visual Acuity - physiology ; Visual Field Tests</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2015-12, Vol.253 (12), p.2293-2299</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-ff55b0105875e9fd353b9419d5315438dc2885140d85acc4e8e20878e3cbec233</citedby><cites>FETCH-LOGICAL-c475t-ff55b0105875e9fd353b9419d5315438dc2885140d85acc4e8e20878e3cbec233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00417-015-3150-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00417-015-3150-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26344730$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, Jinu</creatorcontrib><creatorcontrib>Byun, Min Kwang</creatorcontrib><creatorcontrib>Lee, Junwon</creatorcontrib><creatorcontrib>Han, So Young</creatorcontrib><creatorcontrib>Lee, Jong Bok</creatorcontrib><creatorcontrib>Han, Sueng-Han</creatorcontrib><title>Longitudinal analysis of retinal nerve fiber layer and ganglion cell–inner plexiform layer thickness in ethambutol-induced optic neuropathy</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Purpose
The aim of the study was to evaluate longitudinal analysis of peripapillary retinal nerve fiber layer (RNFL) and perifoveal ganglion cell–inner plexiform layer (GCIPL) thickness in patients being treated with ethambutol (EMB).
Methods
This prospective longitudinal cohort study enrolled 37 patients who were treated with EMB for pulmonary tuberculosis. Best-corrected visual acuity, color vision test, automated perimetry, fundus photography, and RNFL and GCIPL thickness were measured at baseline and at 4 and 6 months after the start of EMB treatment, using Cirrus optical coherence tomography.
Results
Among 37 patients, EMB-induced optic neuropathy occurred in one patient (2.7 %). In this patient, thickening of the RFNL and thinning of the GCIPL were noted at the onset of symptoms. After discontinuation of EMB, RNFL and GCIPL thickness progressively normalized. Changes in RNFL and GCIPL thickness were not statistically significant in the 36 patients who did not exhibit EMB-induced optic neuropathy-related symptoms during follow-up (all
P
values > 0.05).
Conclusions
Thickening of the peripapillary RNFL and thinning of the perifoveal GCIPL is an effective quantitative and early marker for diagnosis of EMB-induced optic neuropathy.</description><subject>Adult</subject><subject>Aged</subject><subject>Antitubercular Agents - adverse effects</subject><subject>Color Vision - physiology</subject><subject>Ethambutol - adverse effects</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mycobacterium</subject><subject>Nerve Fibers - pathology</subject><subject>Neurophthalmology</subject><subject>Ophthalmology</subject><subject>Optic Nerve Diseases - chemically induced</subject><subject>Optic Nerve Diseases - diagnosis</subject><subject>Prospective Studies</subject><subject>Retinal Ganglion Cells - pathology</subject><subject>Tomography, Optical Coherence</subject><subject>Tuberculosis, Pulmonary - drug therapy</subject><subject>Visual Acuity - physiology</subject><subject>Visual Field Tests</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkc-KFDEQxoMo7rj6AF4k4GUvcfN3kjnK4qow4GWFvTXppHoma3fSJt2Lc9sX2JNv6JOY2RlFBMFLFVR-9X2kPoReMvqGUarPC6WSaUKZIoIpSswjtGBSKKIpv36MFlRzRozg1yfoWSk3tOJCsafohC-FlFrQBbpfp7gJ0-xDtD22texKKDh1OMP0MIuQbwF3oYWMe7ur1UaPNzZu-pAidtD3P-6-h1g5PPbwLXQpD0dy2gb3JUIpOEQM09YO7TylnoToZwcep3EKrjrMOY122u6eoyed7Qu8OPZT9Pny3dXFB7L-9P7jxds1cVKriXSdUi1lVBmtYNV5oUS7kmzlVT2DFMY7boxiknqjrHMSDHBqtAHhWnBciFN0dtAdc_o6Q5maIZT9T2yENJeGacU409zo_0CrO19W0Yq-_gu9SXOuN3yg5JIqIUyl2IFyOZWSoWvGHAabdw2jzT7W5hBrU2Nt9rE2-51XR-W5HcD_3viVYwX4ASj1KW4g_2H9T9Wf0VCv6Q</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Han, Jinu</creator><creator>Byun, Min Kwang</creator><creator>Lee, Junwon</creator><creator>Han, So Young</creator><creator>Lee, Jong Bok</creator><creator>Han, Sueng-Han</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20151201</creationdate><title>Longitudinal analysis of retinal nerve fiber layer and ganglion cell–inner plexiform layer thickness in ethambutol-induced optic neuropathy</title><author>Han, Jinu ; Byun, Min Kwang ; Lee, Junwon ; Han, So Young ; Lee, Jong Bok ; Han, Sueng-Han</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-ff55b0105875e9fd353b9419d5315438dc2885140d85acc4e8e20878e3cbec233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antitubercular Agents - adverse effects</topic><topic>Color Vision - physiology</topic><topic>Ethambutol - adverse effects</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mycobacterium</topic><topic>Nerve Fibers - pathology</topic><topic>Neurophthalmology</topic><topic>Ophthalmology</topic><topic>Optic Nerve Diseases - chemically induced</topic><topic>Optic Nerve Diseases - diagnosis</topic><topic>Prospective Studies</topic><topic>Retinal Ganglion Cells - pathology</topic><topic>Tomography, Optical Coherence</topic><topic>Tuberculosis, Pulmonary - drug therapy</topic><topic>Visual Acuity - physiology</topic><topic>Visual Field Tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, Jinu</creatorcontrib><creatorcontrib>Byun, Min Kwang</creatorcontrib><creatorcontrib>Lee, Junwon</creatorcontrib><creatorcontrib>Han, So Young</creatorcontrib><creatorcontrib>Lee, Jong Bok</creatorcontrib><creatorcontrib>Han, Sueng-Han</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Jinu</au><au>Byun, Min Kwang</au><au>Lee, Junwon</au><au>Han, So Young</au><au>Lee, Jong Bok</au><au>Han, Sueng-Han</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal analysis of retinal nerve fiber layer and ganglion cell–inner plexiform layer thickness in ethambutol-induced optic neuropathy</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>253</volume><issue>12</issue><spage>2293</spage><epage>2299</epage><pages>2293-2299</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>Purpose
The aim of the study was to evaluate longitudinal analysis of peripapillary retinal nerve fiber layer (RNFL) and perifoveal ganglion cell–inner plexiform layer (GCIPL) thickness in patients being treated with ethambutol (EMB).
Methods
This prospective longitudinal cohort study enrolled 37 patients who were treated with EMB for pulmonary tuberculosis. Best-corrected visual acuity, color vision test, automated perimetry, fundus photography, and RNFL and GCIPL thickness were measured at baseline and at 4 and 6 months after the start of EMB treatment, using Cirrus optical coherence tomography.
Results
Among 37 patients, EMB-induced optic neuropathy occurred in one patient (2.7 %). In this patient, thickening of the RFNL and thinning of the GCIPL were noted at the onset of symptoms. After discontinuation of EMB, RNFL and GCIPL thickness progressively normalized. Changes in RNFL and GCIPL thickness were not statistically significant in the 36 patients who did not exhibit EMB-induced optic neuropathy-related symptoms during follow-up (all
P
values > 0.05).
Conclusions
Thickening of the peripapillary RNFL and thinning of the perifoveal GCIPL is an effective quantitative and early marker for diagnosis of EMB-induced optic neuropathy.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26344730</pmid><doi>10.1007/s00417-015-3150-8</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0721-832X |
| ispartof | Graefe's archive for clinical and experimental ophthalmology, 2015-12, Vol.253 (12), p.2293-2299 |
| issn | 0721-832X 1435-702X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1751217287 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Aged Antitubercular Agents - adverse effects Color Vision - physiology Ethambutol - adverse effects Female Follow-Up Studies Humans Male Medicine Medicine & Public Health Middle Aged Mycobacterium Nerve Fibers - pathology Neurophthalmology Ophthalmology Optic Nerve Diseases - chemically induced Optic Nerve Diseases - diagnosis Prospective Studies Retinal Ganglion Cells - pathology Tomography, Optical Coherence Tuberculosis, Pulmonary - drug therapy Visual Acuity - physiology Visual Field Tests |
| title | Longitudinal analysis of retinal nerve fiber layer and ganglion cell–inner plexiform layer thickness in ethambutol-induced optic neuropathy |
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