Streptozotocin Aggravated Osteopathology and Insulin Induced Osteogenesis Through Co-treatment with Fluoride
The role of insulin in the mechanism underlying the excessive fluoride that causes skeletal lesion was studied. The in vitro bone marrow stem cells (BMSC) collected from Kunming mice were exposed to varying concentrations of fluoride with or without insulin. The cell viability and early differentiat...
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| Veröffentlicht in: | Biological trace element research 2015-12, Vol.168 (2), p.453-461 |
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| creator | Yang, Chen Zhang, Mengmeng Li, Yagang Wang, Yan Mao, Weixian Gao, Yuan Xu, Hui |
| description | The role of insulin in the mechanism underlying the excessive fluoride that causes skeletal lesion was studied. The in vitro bone marrow stem cells (BMSC) collected from Kunming mice were exposed to varying concentrations of fluoride with or without insulin. The cell viability and early differentiation of BMSC co-treated with fluoride and insulin were measured by using cell counting kit-8 and Gomori modified calcium–cobalt method, respectively. We further investigated the in vivo effects of varying dose of fluoride on rats co-treated with streptozotocin (STZ). Wistar rats were divided into six groups which included normal control, 10 mg fluoride/kg day group, 20 mg fluoride/kg day group, STZ control, STZ + 10 mg fluoride/kg day group, and STZ + 20 mg fluoride/kg day group. The rats were administered with sodium fluoride (NaF) by gavage with water at doses 10 and 20 mg fluoride/kg day for 2 months. In a period of one month, half of rats in every group were treated with streptozotocin (STZ) once through intraperitoneal injection at 52 mg/kg body weight. The serum glucose, HbA1c, and insulin were determined. Bone mineral content and insulin release were assessed. The results showed insulin combined with fluoride stimulated BMSC cell viability in vitro. The bone mineral content reduced in rats treated with higher dose of fluoride and decreased immensely in rat co-treated with fluoride and STZ. Similarly, a combination treatment of a high dose of fluoride and STZ decreased insulin sensitivity and activity. To sum up, these data indicated fluoride influenced insulin release, activity, and sensitivity. Furthermore, the insulin state in vivo interfered in the osteogenesis in turn and implied there was a close relation between insulin and bone pathogenesis in the mechanism of fluoride toxicity. |
| doi_str_mv | 10.1007/s12011-015-0374-8 |
| format | Article |
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The in vitro bone marrow stem cells (BMSC) collected from Kunming mice were exposed to varying concentrations of fluoride with or without insulin. The cell viability and early differentiation of BMSC co-treated with fluoride and insulin were measured by using cell counting kit-8 and Gomori modified calcium–cobalt method, respectively. We further investigated the in vivo effects of varying dose of fluoride on rats co-treated with streptozotocin (STZ). Wistar rats were divided into six groups which included normal control, 10 mg fluoride/kg day group, 20 mg fluoride/kg day group, STZ control, STZ + 10 mg fluoride/kg day group, and STZ + 20 mg fluoride/kg day group. The rats were administered with sodium fluoride (NaF) by gavage with water at doses 10 and 20 mg fluoride/kg day for 2 months. In a period of one month, half of rats in every group were treated with streptozotocin (STZ) once through intraperitoneal injection at 52 mg/kg body weight. The serum glucose, HbA1c, and insulin were determined. Bone mineral content and insulin release were assessed. The results showed insulin combined with fluoride stimulated BMSC cell viability in vitro. The bone mineral content reduced in rats treated with higher dose of fluoride and decreased immensely in rat co-treated with fluoride and STZ. Similarly, a combination treatment of a high dose of fluoride and STZ decreased insulin sensitivity and activity. To sum up, these data indicated fluoride influenced insulin release, activity, and sensitivity. Furthermore, the insulin state in vivo interfered in the osteogenesis in turn and implied there was a close relation between insulin and bone pathogenesis in the mechanism of fluoride toxicity.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/s12011-015-0374-8</identifier><identifier>PMID: 26018496</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Alkaline Phosphatase - metabolism ; Animals ; Biochemistry ; Biomedical and Life Sciences ; Biotechnology ; blood glucose ; Blood Glucose - analysis ; Body weight ; Bone and Bones - drug effects ; Bone and Bones - pathology ; Bone Density - drug effects ; bone formation ; Bone marrow ; Bone Marrow Cells - drug effects ; Cell Differentiation ; Cell Survival ; cell viability ; Cobalt ; Fluorides ; Fluorides - toxicity ; Glycated Hemoglobin A - metabolism ; Immunohistochemistry ; Insulin ; Insulin - administration & dosage ; Insulin - metabolism ; insulin resistance ; intraperitoneal injection ; Islets of Langerhans - cytology ; Life Sciences ; Mice ; mineral content ; Nutrition ; Oncology ; Osteoblasts - drug effects ; Osteogenesis - drug effects ; pathogenesis ; Rats ; Rats, Wistar ; sodium fluoride ; Sodium Fluoride - adverse effects ; Stem cells ; Streptozocin - adverse effects ; streptozotocin ; toxicity</subject><ispartof>Biological trace element research, 2015-12, Vol.168 (2), p.453-461</ispartof><rights>Springer Science+Business Media New York 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-c9e80b6bd2a0d510a7ba2bcc5f8ee06d838a72f12b2594ffa30e82927a153ffc3</citedby><cites>FETCH-LOGICAL-c499t-c9e80b6bd2a0d510a7ba2bcc5f8ee06d838a72f12b2594ffa30e82927a153ffc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12011-015-0374-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12011-015-0374-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26018496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Chen</creatorcontrib><creatorcontrib>Zhang, Mengmeng</creatorcontrib><creatorcontrib>Li, Yagang</creatorcontrib><creatorcontrib>Wang, Yan</creatorcontrib><creatorcontrib>Mao, Weixian</creatorcontrib><creatorcontrib>Gao, Yuan</creatorcontrib><creatorcontrib>Xu, Hui</creatorcontrib><title>Streptozotocin Aggravated Osteopathology and Insulin Induced Osteogenesis Through Co-treatment with Fluoride</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><addtitle>Biol Trace Elem Res</addtitle><description>The role of insulin in the mechanism underlying the excessive fluoride that causes skeletal lesion was studied. The in vitro bone marrow stem cells (BMSC) collected from Kunming mice were exposed to varying concentrations of fluoride with or without insulin. The cell viability and early differentiation of BMSC co-treated with fluoride and insulin were measured by using cell counting kit-8 and Gomori modified calcium–cobalt method, respectively. We further investigated the in vivo effects of varying dose of fluoride on rats co-treated with streptozotocin (STZ). Wistar rats were divided into six groups which included normal control, 10 mg fluoride/kg day group, 20 mg fluoride/kg day group, STZ control, STZ + 10 mg fluoride/kg day group, and STZ + 20 mg fluoride/kg day group. The rats were administered with sodium fluoride (NaF) by gavage with water at doses 10 and 20 mg fluoride/kg day for 2 months. In a period of one month, half of rats in every group were treated with streptozotocin (STZ) once through intraperitoneal injection at 52 mg/kg body weight. The serum glucose, HbA1c, and insulin were determined. Bone mineral content and insulin release were assessed. The results showed insulin combined with fluoride stimulated BMSC cell viability in vitro. The bone mineral content reduced in rats treated with higher dose of fluoride and decreased immensely in rat co-treated with fluoride and STZ. Similarly, a combination treatment of a high dose of fluoride and STZ decreased insulin sensitivity and activity. To sum up, these data indicated fluoride influenced insulin release, activity, and sensitivity. Furthermore, the insulin state in vivo interfered in the osteogenesis in turn and implied there was a close relation between insulin and bone pathogenesis in the mechanism of fluoride toxicity.</description><subject>Alkaline Phosphatase - metabolism</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>blood glucose</subject><subject>Blood Glucose - analysis</subject><subject>Body weight</subject><subject>Bone and Bones - drug effects</subject><subject>Bone and Bones - pathology</subject><subject>Bone Density - drug effects</subject><subject>bone formation</subject><subject>Bone marrow</subject><subject>Bone Marrow Cells - drug effects</subject><subject>Cell Differentiation</subject><subject>Cell Survival</subject><subject>cell viability</subject><subject>Cobalt</subject><subject>Fluorides</subject><subject>Fluorides - toxicity</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Immunohistochemistry</subject><subject>Insulin</subject><subject>Insulin - administration & dosage</subject><subject>Insulin - metabolism</subject><subject>insulin resistance</subject><subject>intraperitoneal injection</subject><subject>Islets of Langerhans - cytology</subject><subject>Life Sciences</subject><subject>Mice</subject><subject>mineral content</subject><subject>Nutrition</subject><subject>Oncology</subject><subject>Osteoblasts - drug effects</subject><subject>Osteogenesis - drug effects</subject><subject>pathogenesis</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>sodium fluoride</subject><subject>Sodium Fluoride - adverse effects</subject><subject>Stem cells</subject><subject>Streptozocin - adverse effects</subject><subject>streptozotocin</subject><subject>toxicity</subject><issn>0163-4984</issn><issn>1559-0720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kcFuFSEUhonR2NvqA7jRSdy4QQ8wDLBsbqy9SZMu2q4Jw8DcaebCFRhNfXpppjXGhSsW5_v_Q86H0DsCnwmA-JIJBUIwEI6BiRbLF2hDOFcYBIWXaAOkY7hVsj1BpznfAxBBFXuNTmgHRLaq26D5piR3LPFXLNFOoTkfx2R-mOKG5joXF4-m7OMcx4fGhKHZhbzMldqFYbHPyOiCy1NubvcpLuO-2UZcO005uFCan1PZNxfzEtM0uDfolTdzdm-f3jN0d_H1dnuJr66_7bbnV9i2ShVslZPQd_1ADQycgBG9ob213EvnoBskk0ZQT2hPuWq9NwycpIoKQzjz3rIz9GntPab4fXG56MOUrZtnE1xcsiaCE0oEdLSiH_9B7-OSQv1dpRjljINqK0VWyqaYc3JeH9N0MOlBE9CPKvSqQlcV-lGFljXz_ql56Q9u-JN4vn0F6ArkOgqjS3-t_k_rhzXkTdRmTFPWdzcV6qDa5Vxy9hv_1p6y</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Yang, Chen</creator><creator>Zhang, Mengmeng</creator><creator>Li, Yagang</creator><creator>Wang, Yan</creator><creator>Mao, Weixian</creator><creator>Gao, Yuan</creator><creator>Xu, Hui</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QH</scope><scope>7QP</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H97</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope></search><sort><creationdate>20151201</creationdate><title>Streptozotocin Aggravated Osteopathology and Insulin Induced Osteogenesis Through Co-treatment with Fluoride</title><author>Yang, Chen ; Zhang, Mengmeng ; Li, Yagang ; Wang, Yan ; Mao, Weixian ; Gao, Yuan ; Xu, Hui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-c9e80b6bd2a0d510a7ba2bcc5f8ee06d838a72f12b2594ffa30e82927a153ffc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Alkaline Phosphatase - metabolism</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>blood glucose</topic><topic>Blood Glucose - analysis</topic><topic>Body weight</topic><topic>Bone and Bones - drug effects</topic><topic>Bone and Bones - pathology</topic><topic>Bone Density - drug effects</topic><topic>bone formation</topic><topic>Bone marrow</topic><topic>Bone Marrow Cells - drug effects</topic><topic>Cell Differentiation</topic><topic>Cell Survival</topic><topic>cell viability</topic><topic>Cobalt</topic><topic>Fluorides</topic><topic>Fluorides - toxicity</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Immunohistochemistry</topic><topic>Insulin</topic><topic>Insulin - administration & dosage</topic><topic>Insulin - metabolism</topic><topic>insulin resistance</topic><topic>intraperitoneal injection</topic><topic>Islets of Langerhans - cytology</topic><topic>Life Sciences</topic><topic>Mice</topic><topic>mineral content</topic><topic>Nutrition</topic><topic>Oncology</topic><topic>Osteoblasts - drug effects</topic><topic>Osteogenesis - drug effects</topic><topic>pathogenesis</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>sodium fluoride</topic><topic>Sodium Fluoride - adverse effects</topic><topic>Stem cells</topic><topic>Streptozocin - adverse effects</topic><topic>streptozotocin</topic><topic>toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Chen</creatorcontrib><creatorcontrib>Zhang, Mengmeng</creatorcontrib><creatorcontrib>Li, Yagang</creatorcontrib><creatorcontrib>Wang, Yan</creatorcontrib><creatorcontrib>Mao, Weixian</creatorcontrib><creatorcontrib>Gao, Yuan</creatorcontrib><creatorcontrib>Xu, Hui</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aqualine</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Biological trace element research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Chen</au><au>Zhang, Mengmeng</au><au>Li, Yagang</au><au>Wang, Yan</au><au>Mao, Weixian</au><au>Gao, Yuan</au><au>Xu, Hui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Streptozotocin Aggravated Osteopathology and Insulin Induced Osteogenesis Through Co-treatment with Fluoride</atitle><jtitle>Biological trace element research</jtitle><stitle>Biol Trace Elem Res</stitle><addtitle>Biol Trace Elem Res</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>168</volume><issue>2</issue><spage>453</spage><epage>461</epage><pages>453-461</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><abstract>The role of insulin in the mechanism underlying the excessive fluoride that causes skeletal lesion was studied. The in vitro bone marrow stem cells (BMSC) collected from Kunming mice were exposed to varying concentrations of fluoride with or without insulin. The cell viability and early differentiation of BMSC co-treated with fluoride and insulin were measured by using cell counting kit-8 and Gomori modified calcium–cobalt method, respectively. We further investigated the in vivo effects of varying dose of fluoride on rats co-treated with streptozotocin (STZ). Wistar rats were divided into six groups which included normal control, 10 mg fluoride/kg day group, 20 mg fluoride/kg day group, STZ control, STZ + 10 mg fluoride/kg day group, and STZ + 20 mg fluoride/kg day group. The rats were administered with sodium fluoride (NaF) by gavage with water at doses 10 and 20 mg fluoride/kg day for 2 months. In a period of one month, half of rats in every group were treated with streptozotocin (STZ) once through intraperitoneal injection at 52 mg/kg body weight. The serum glucose, HbA1c, and insulin were determined. Bone mineral content and insulin release were assessed. The results showed insulin combined with fluoride stimulated BMSC cell viability in vitro. The bone mineral content reduced in rats treated with higher dose of fluoride and decreased immensely in rat co-treated with fluoride and STZ. Similarly, a combination treatment of a high dose of fluoride and STZ decreased insulin sensitivity and activity. To sum up, these data indicated fluoride influenced insulin release, activity, and sensitivity. Furthermore, the insulin state in vivo interfered in the osteogenesis in turn and implied there was a close relation between insulin and bone pathogenesis in the mechanism of fluoride toxicity.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>26018496</pmid><doi>10.1007/s12011-015-0374-8</doi><tpages>9</tpages></addata></record> |
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| subjects | Alkaline Phosphatase - metabolism Animals Biochemistry Biomedical and Life Sciences Biotechnology blood glucose Blood Glucose - analysis Body weight Bone and Bones - drug effects Bone and Bones - pathology Bone Density - drug effects bone formation Bone marrow Bone Marrow Cells - drug effects Cell Differentiation Cell Survival cell viability Cobalt Fluorides Fluorides - toxicity Glycated Hemoglobin A - metabolism Immunohistochemistry Insulin Insulin - administration & dosage Insulin - metabolism insulin resistance intraperitoneal injection Islets of Langerhans - cytology Life Sciences Mice mineral content Nutrition Oncology Osteoblasts - drug effects Osteogenesis - drug effects pathogenesis Rats Rats, Wistar sodium fluoride Sodium Fluoride - adverse effects Stem cells Streptozocin - adverse effects streptozotocin toxicity |
| title | Streptozotocin Aggravated Osteopathology and Insulin Induced Osteogenesis Through Co-treatment with Fluoride |
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