Citrate gold nanoparticle exposure in the marine bivalve Ruditapes philippinarum: uptake, elimination and oxidative stress response
Gold nanoparticles (AuNPs) are considered an important nano-sized component of the twenty-first century. Due to their unique physical and chemical properties, they are being used and developed for a wide range of promising applications in medicine, biology and chemistry. Notwithstanding their useful...
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| Veröffentlicht in: | Environmental science and pollution research international 2015-11, Vol.22 (22), p.17414-17424 |
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| creator | Volland, Moritz Hampel, Miriam Martos-Sitcha, Juan A Trombini, Chiara Martínez-Rodríguez, Gonzalo Blasco, Julián |
| description | Gold nanoparticles (AuNPs) are considered an important nano-sized component of the twenty-first century. Due to their unique physical and chemical properties, they are being used and developed for a wide range of promising applications in medicine, biology and chemistry. Notwithstanding their useful aspects, in recent years concern has been raised over their ability to enter cells, organelles and nuclei and provoke oxidative stress. In a laboratory-based experiment, the non-target marine bivalve Ruditapes philippinarum was used as a model organism. Uptake, elimination and molecular effects under short-term and sub-chronic exposure conditions to an environmental relevant concentration (0.75 μg L⁻¹) of weakly agglomerating citrate AuNPs (∼20 nm) were studied. Our results demonstrate that at the tested concentration, the particles are readily taken up into the digestive gland > gills and can produce significant changes (p |
| doi_str_mv | 10.1007/s11356-015-4718-x |
| format | Article |
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Due to their unique physical and chemical properties, they are being used and developed for a wide range of promising applications in medicine, biology and chemistry. Notwithstanding their useful aspects, in recent years concern has been raised over their ability to enter cells, organelles and nuclei and provoke oxidative stress. In a laboratory-based experiment, the non-target marine bivalve Ruditapes philippinarum was used as a model organism. Uptake, elimination and molecular effects under short-term and sub-chronic exposure conditions to an environmental relevant concentration (0.75 μg L⁻¹) of weakly agglomerating citrate AuNPs (∼20 nm) were studied. Our results demonstrate that at the tested concentration, the particles are readily taken up into the digestive gland > gills and can produce significant changes (p < 0.05) in oxidative stress and inflammatory response markers, as measured by phase II antioxidant enzymes and q-PCR gene expression analysis. However, the overall magnitude of responses was low, and oxidative damage was not provoked. Further, a significant elimination of Au from the digestive tract within a 7-day purification period was observed, with excretion being an important pathway. In conclusion, short-term and sub-chronic exposure to an environmental relevant concentration of citrate-stabilized AuNPs cannot be considered toxic to our model organism, while some further consideration should be given to chronic exposure effects.</description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-015-4718-x</identifier><identifier>PMID: 25994271</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; Antioxidants ; Aquatic ecosystems ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Bivalvia ; Bivalvia - drug effects ; Cellular stress response ; Chemical properties ; Chemistry ; Chronic exposure ; Chronic illnesses ; citrates ; Citric acid ; Citric Acid - toxicity ; Digestive glands ; digestive tract ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; environmental exposure ; Environmental Health ; Enzymes ; excretion ; Gastrointestinal tract ; Gene expression ; Gills ; Gold ; Gold - toxicity ; Inflammation ; Laboratories ; Marine ecosystems ; Market penetration ; medicine ; Metal Nanoparticles - toxicity ; Molecular and Cellular Effects of Contamination in Aquatic Ecosystems ; Mollusks ; nanogold ; Nanoparticles ; Organelles ; Oxidative stress ; Oxidative Stress - drug effects ; Particle size ; physicochemical properties ; Ruditapes philippinarum ; Shellfish ; stress response ; subchronic exposure ; Toxicity ; Waste Water Technology ; Water Management ; Water Pollution Control</subject><ispartof>Environmental science and pollution research international, 2015-11, Vol.22 (22), p.17414-17424</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-d230060e1ed6846c8c47e968c099c46e1a6e5f4fd3de4785d89d7c9a1dcc3c783</citedby><cites>FETCH-LOGICAL-c499t-d230060e1ed6846c8c47e968c099c46e1a6e5f4fd3de4785d89d7c9a1dcc3c783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-015-4718-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-015-4718-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25994271$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Volland, Moritz</creatorcontrib><creatorcontrib>Hampel, Miriam</creatorcontrib><creatorcontrib>Martos-Sitcha, Juan A</creatorcontrib><creatorcontrib>Trombini, Chiara</creatorcontrib><creatorcontrib>Martínez-Rodríguez, Gonzalo</creatorcontrib><creatorcontrib>Blasco, Julián</creatorcontrib><title>Citrate gold nanoparticle exposure in the marine bivalve Ruditapes philippinarum: uptake, elimination and oxidative stress response</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>Gold nanoparticles (AuNPs) are considered an important nano-sized component of the twenty-first century. Due to their unique physical and chemical properties, they are being used and developed for a wide range of promising applications in medicine, biology and chemistry. Notwithstanding their useful aspects, in recent years concern has been raised over their ability to enter cells, organelles and nuclei and provoke oxidative stress. In a laboratory-based experiment, the non-target marine bivalve Ruditapes philippinarum was used as a model organism. Uptake, elimination and molecular effects under short-term and sub-chronic exposure conditions to an environmental relevant concentration (0.75 μg L⁻¹) of weakly agglomerating citrate AuNPs (∼20 nm) were studied. Our results demonstrate that at the tested concentration, the particles are readily taken up into the digestive gland > gills and can produce significant changes (p < 0.05) in oxidative stress and inflammatory response markers, as measured by phase II antioxidant enzymes and q-PCR gene expression analysis. However, the overall magnitude of responses was low, and oxidative damage was not provoked. Further, a significant elimination of Au from the digestive tract within a 7-day purification period was observed, with excretion being an important pathway. In conclusion, short-term and sub-chronic exposure to an environmental relevant concentration of citrate-stabilized AuNPs cannot be considered toxic to our model organism, while some further consideration should be given to chronic exposure effects.</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Aquatic ecosystems</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Bivalvia</subject><subject>Bivalvia - drug effects</subject><subject>Cellular stress response</subject><subject>Chemical properties</subject><subject>Chemistry</subject><subject>Chronic exposure</subject><subject>Chronic illnesses</subject><subject>citrates</subject><subject>Citric acid</subject><subject>Citric Acid - toxicity</subject><subject>Digestive glands</subject><subject>digestive tract</subject><subject>Earth and Environmental 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properties</subject><subject>Ruditapes philippinarum</subject><subject>Shellfish</subject><subject>stress response</subject><subject>subchronic exposure</subject><subject>Toxicity</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution 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gold nanoparticle exposure in the marine bivalve Ruditapes philippinarum: uptake, elimination and oxidative stress response</title><author>Volland, Moritz ; Hampel, Miriam ; Martos-Sitcha, Juan A ; Trombini, Chiara ; Martínez-Rodríguez, Gonzalo ; Blasco, Julián</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-d230060e1ed6846c8c47e968c099c46e1a6e5f4fd3de4785d89d7c9a1dcc3c783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Antioxidants</topic><topic>Aquatic ecosystems</topic><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Bivalvia</topic><topic>Bivalvia - drug effects</topic><topic>Cellular stress response</topic><topic>Chemical properties</topic><topic>Chemistry</topic><topic>Chronic exposure</topic><topic>Chronic illnesses</topic><topic>citrates</topic><topic>Citric 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Int</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>22</volume><issue>22</issue><spage>17414</spage><epage>17424</epage><pages>17414-17424</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>Gold nanoparticles (AuNPs) are considered an important nano-sized component of the twenty-first century. Due to their unique physical and chemical properties, they are being used and developed for a wide range of promising applications in medicine, biology and chemistry. Notwithstanding their useful aspects, in recent years concern has been raised over their ability to enter cells, organelles and nuclei and provoke oxidative stress. In a laboratory-based experiment, the non-target marine bivalve Ruditapes philippinarum was used as a model organism. Uptake, elimination and molecular effects under short-term and sub-chronic exposure conditions to an environmental relevant concentration (0.75 μg L⁻¹) of weakly agglomerating citrate AuNPs (∼20 nm) were studied. Our results demonstrate that at the tested concentration, the particles are readily taken up into the digestive gland > gills and can produce significant changes (p < 0.05) in oxidative stress and inflammatory response markers, as measured by phase II antioxidant enzymes and q-PCR gene expression analysis. However, the overall magnitude of responses was low, and oxidative damage was not provoked. Further, a significant elimination of Au from the digestive tract within a 7-day purification period was observed, with excretion being an important pathway. In conclusion, short-term and sub-chronic exposure to an environmental relevant concentration of citrate-stabilized AuNPs cannot be considered toxic to our model organism, while some further consideration should be given to chronic exposure effects.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25994271</pmid><doi>10.1007/s11356-015-4718-x</doi><tpages>11</tpages></addata></record> |
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| subjects | Animals Antioxidants Aquatic ecosystems Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Bivalvia Bivalvia - drug effects Cellular stress response Chemical properties Chemistry Chronic exposure Chronic illnesses citrates Citric acid Citric Acid - toxicity Digestive glands digestive tract Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry environmental exposure Environmental Health Enzymes excretion Gastrointestinal tract Gene expression Gills Gold Gold - toxicity Inflammation Laboratories Marine ecosystems Market penetration medicine Metal Nanoparticles - toxicity Molecular and Cellular Effects of Contamination in Aquatic Ecosystems Mollusks nanogold Nanoparticles Organelles Oxidative stress Oxidative Stress - drug effects Particle size physicochemical properties Ruditapes philippinarum Shellfish stress response subchronic exposure Toxicity Waste Water Technology Water Management Water Pollution Control |
| title | Citrate gold nanoparticle exposure in the marine bivalve Ruditapes philippinarum: uptake, elimination and oxidative stress response |
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