MicroRNA-224: as a potential target for miR-based therapy of cancer
MicroRNAs (miRNAs) are small noncoding RNA molecules which regulate the target gene expression posttranscriptionally. Increasing studies have shown that microRNAs play important roles in multiple biological pathways. For instance, aberrant expression of microRNA-224 (miR-224) plays a vital role in t...
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| Veröffentlicht in: | Tumor biology 2015-09, Vol.36 (9), p.6645-6652 |
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| container_title | Tumor biology |
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| creator | Chen, Wei Fan, Xue-mei Mao, Ling Zhang, Jun-ying LI, Jian Wu, Jian-zhong Tang, Jin-hai |
| description | MicroRNAs (miRNAs) are small noncoding RNA molecules which regulate the target gene expression posttranscriptionally. Increasing studies have shown that microRNAs play important roles in multiple biological pathways. For instance, aberrant expression of microRNA-224 (miR-224) plays a vital role in tumor biology in various types of human cancer. Here, we aim to summarize the molecular mechanisms that lead to the overexpression of miR-224 in cancers, analyze the effect of miR-224 on tumor biology, and reveal the clinical significance of miR-224. MiR-224 regulates its targets by modulating messenger RNA (mRNA) stability and/or protein translation, and it would provide new insight into molecular targeting cancer treatment. |
| doi_str_mv | 10.1007/s13277-015-3883-3 |
| format | Article |
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Increasing studies have shown that microRNAs play important roles in multiple biological pathways. For instance, aberrant expression of microRNA-224 (miR-224) plays a vital role in tumor biology in various types of human cancer. Here, we aim to summarize the molecular mechanisms that lead to the overexpression of miR-224 in cancers, analyze the effect of miR-224 on tumor biology, and reveal the clinical significance of miR-224. MiR-224 regulates its targets by modulating messenger RNA (mRNA) stability and/or protein translation, and it would provide new insight into molecular targeting cancer treatment.</description><identifier>ISSN: 1010-4283</identifier><identifier>EISSN: 1423-0380</identifier><identifier>DOI: 10.1007/s13277-015-3883-3</identifier><identifier>PMID: 26254100</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Biomarkers ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - therapeutic use ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Cancer therapies ; Carcinogenesis - genetics ; Gene Expression Regulation, Neoplastic ; Genetic Therapy ; Humans ; MicroRNAs ; MicroRNAs - genetics ; MicroRNAs - therapeutic use ; Molecular biology ; Neoplasms - genetics ; Neoplasms - pathology ; Neoplasms - therapy ; Review</subject><ispartof>Tumor biology, 2015-09, Vol.36 (9), p.6645-6652</ispartof><rights>International Society of Oncology and BioMarkers (ISOBM) 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-e48258f1a5fc6fa5121a2e4e2c847467dc8caa936ba0b1981d9ee8c2789726c03</citedby><cites>FETCH-LOGICAL-c541t-e48258f1a5fc6fa5121a2e4e2c847467dc8caa936ba0b1981d9ee8c2789726c03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13277-015-3883-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13277-015-3883-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26254100$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Wei</creatorcontrib><creatorcontrib>Fan, Xue-mei</creatorcontrib><creatorcontrib>Mao, Ling</creatorcontrib><creatorcontrib>Zhang, Jun-ying</creatorcontrib><creatorcontrib>LI, Jian</creatorcontrib><creatorcontrib>Wu, Jian-zhong</creatorcontrib><creatorcontrib>Tang, Jin-hai</creatorcontrib><title>MicroRNA-224: as a potential target for miR-based therapy of cancer</title><title>Tumor biology</title><addtitle>Tumor Biol</addtitle><addtitle>Tumour Biol</addtitle><description>MicroRNAs (miRNAs) are small noncoding RNA molecules which regulate the target gene expression posttranscriptionally. 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MiR-224 regulates its targets by modulating messenger RNA (mRNA) stability and/or protein translation, and it would provide new insight into molecular targeting cancer treatment.</description><subject>Biomarkers</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - therapeutic use</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Cancer therapies</subject><subject>Carcinogenesis - genetics</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genetic Therapy</subject><subject>Humans</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - therapeutic use</subject><subject>Molecular biology</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - pathology</subject><subject>Neoplasms - therapy</subject><subject>Review</subject><issn>1010-4283</issn><issn>1423-0380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkctKAzEUhoMotlYfwI0E3LiJ5jZJxl0p3sALFF2HNHOmTmlnxmRm0bc3pVVEEFwlkO98h_w_QqeMXjJK9VVkgmtNKMuIMEYQsYeGTHJBqDB0P90po0RyIwboKMYFTWCeq0M04IpnMimGaPJU-dBMn8eEc3mNXcQOt00HdVe5Je5cmEOHyybgVTUlMxehwN07BNeucVNi72oP4RgdlG4Z4WR3jtDb7c3r5J48vtw9TMaPxKdlHQFpeGZK5rLSq9JljDPHQQL3RmqpdOGNdy4XaubojOWGFTmA8VybXHPlqRihi623Dc1HD7Gzqyp6WC5dDU0fLdMbpzLqP6gQLEUm8oSe_0IXTR_q9JFEaZkrkbSJYlsqpRVjgNK2oVq5sLaM2k0ZdluGTRnbTRlWpJmznbmfraD4nvhKPwF8C8T0VM8h_Fj9p_UTgWeQpg</recordid><startdate>20150901</startdate><enddate>20150901</enddate><creator>Chen, Wei</creator><creator>Fan, Xue-mei</creator><creator>Mao, Ling</creator><creator>Zhang, Jun-ying</creator><creator>LI, Jian</creator><creator>Wu, Jian-zhong</creator><creator>Tang, Jin-hai</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7TM</scope></search><sort><creationdate>20150901</creationdate><title>MicroRNA-224: as a potential target for miR-based therapy of cancer</title><author>Chen, Wei ; Fan, Xue-mei ; Mao, Ling ; Zhang, Jun-ying ; LI, Jian ; Wu, Jian-zhong ; Tang, Jin-hai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-e48258f1a5fc6fa5121a2e4e2c847467dc8caa936ba0b1981d9ee8c2789726c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Biomarkers</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - therapeutic use</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Cancer therapies</topic><topic>Carcinogenesis - genetics</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Genetic Therapy</topic><topic>Humans</topic><topic>MicroRNAs</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - therapeutic use</topic><topic>Molecular biology</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - pathology</topic><topic>Neoplasms - therapy</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Wei</creatorcontrib><creatorcontrib>Fan, Xue-mei</creatorcontrib><creatorcontrib>Mao, Ling</creatorcontrib><creatorcontrib>Zhang, Jun-ying</creatorcontrib><creatorcontrib>LI, Jian</creatorcontrib><creatorcontrib>Wu, Jian-zhong</creatorcontrib><creatorcontrib>Tang, Jin-hai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Nucleic Acids Abstracts</collection><jtitle>Tumor biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Wei</au><au>Fan, Xue-mei</au><au>Mao, Ling</au><au>Zhang, Jun-ying</au><au>LI, Jian</au><au>Wu, Jian-zhong</au><au>Tang, Jin-hai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MicroRNA-224: as a potential target for miR-based therapy of cancer</atitle><jtitle>Tumor biology</jtitle><stitle>Tumor Biol</stitle><addtitle>Tumour Biol</addtitle><date>2015-09-01</date><risdate>2015</risdate><volume>36</volume><issue>9</issue><spage>6645</spage><epage>6652</epage><pages>6645-6652</pages><issn>1010-4283</issn><eissn>1423-0380</eissn><abstract>MicroRNAs (miRNAs) are small noncoding RNA molecules which regulate the target gene expression posttranscriptionally. 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| subjects | Biomarkers Biomarkers, Tumor - genetics Biomarkers, Tumor - therapeutic use Biomedical and Life Sciences Biomedicine Cancer Research Cancer therapies Carcinogenesis - genetics Gene Expression Regulation, Neoplastic Genetic Therapy Humans MicroRNAs MicroRNAs - genetics MicroRNAs - therapeutic use Molecular biology Neoplasms - genetics Neoplasms - pathology Neoplasms - therapy Review |
| title | MicroRNA-224: as a potential target for miR-based therapy of cancer |
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