novel enzyme-based antimicrobial system comprising iodide and a multicopper oxidase isolated from Alphaproteobacterium strain Q-1
Alphaproteobacterium strain Q-1 produces an extracellular multicopper oxidase (IOX), which catalyzes iodide (I–) oxidation to form molecular iodine (I₂). In this study, the antimicrobial activity of the IOX/iodide system was determined. Both Gram-positive and Gram-negative bacteria tested were kille...
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| Veröffentlicht in: | Applied microbiology and biotechnology 2015-12, Vol.99 (23), p.10011-10018 |
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| creator | Yuliana, Tri Ebihara, Kyota Suzuki, Mio Shimonaka, Chie Amachi, Seigo |
| description | Alphaproteobacterium strain Q-1 produces an extracellular multicopper oxidase (IOX), which catalyzes iodide (I–) oxidation to form molecular iodine (I₂). In this study, the antimicrobial activity of the IOX/iodide system was determined. Both Gram-positive and Gram-negative bacteria tested were killed completely within 5 min by 50 mU mL–¹ of IOX and 10 mM iodide. The sporicidal activity of the system was also tested and compared with a common iodophor, povidone-iodine (PVP-I). IOX (300 mU mL–¹) killed Bacillus cereus, B. subtilis, and Geobacillus stearothermophilus spores with decimal reduction times of 2.58, 7.62, and 40.9 min, respectively. However, 0.1 % PVP-I killed these spores with much longer decimal reduction times of 5.46, 38.0, and 260 min, respectively. To evaluate the more superior sporicidal activity of the IOX system over PVP-I, the amount of free iodine (non-complexed I₂) was determined by an equilibrium dialysis technique. The IOX system included more than 40 mg L–¹ of free iodine, while PVP-I included at most 25 mg L–¹ free iodine. Our results suggest that the new enzyme-based antimicrobial system is effective against a wide variety of microorganisms and bacterial spores, and that its strong biocidal activity is due to its high free iodine content, which is probably maintained by re-oxidation of iodide released after oxidation of cell components by I₂. |
| doi_str_mv | 10.1007/s00253-015-6862-0 |
| format | Article |
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In this study, the antimicrobial activity of the IOX/iodide system was determined. Both Gram-positive and Gram-negative bacteria tested were killed completely within 5 min by 50 mU mL–¹ of IOX and 10 mM iodide. The sporicidal activity of the system was also tested and compared with a common iodophor, povidone-iodine (PVP-I). IOX (300 mU mL–¹) killed Bacillus cereus, B. subtilis, and Geobacillus stearothermophilus spores with decimal reduction times of 2.58, 7.62, and 40.9 min, respectively. However, 0.1 % PVP-I killed these spores with much longer decimal reduction times of 5.46, 38.0, and 260 min, respectively. To evaluate the more superior sporicidal activity of the IOX system over PVP-I, the amount of free iodine (non-complexed I₂) was determined by an equilibrium dialysis technique. The IOX system included more than 40 mg L–¹ of free iodine, while PVP-I included at most 25 mg L–¹ free iodine. Our results suggest that the new enzyme-based antimicrobial system is effective against a wide variety of microorganisms and bacterial spores, and that its strong biocidal activity is due to its high free iodine content, which is probably maintained by re-oxidation of iodide released after oxidation of cell components by I₂.</description><identifier>ISSN: 0175-7598</identifier><identifier>EISSN: 1432-0614</identifier><identifier>DOI: 10.1007/s00253-015-6862-0</identifier><identifier>PMID: 26254787</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Alphaproteobacteria - enzymology ; Alphaproteobacteria - metabolism ; Analysis ; Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - metabolism ; Anti-Bacterial Agents - pharmacology ; anti-infective properties ; Antimicrobial agents ; Bacillus cereus ; Bacteria ; bacterial spores ; Biomedical and Life Sciences ; Biotechnologically Relevant Enzymes and Proteins ; Biotechnology ; Cellular biology ; Dialysis ; Disinfection & disinfectants ; E coli ; Enzymes ; Geobacillus ; Geobacillus stearothermophilus ; Gram-negative bacteria ; Gram-Negative Bacteria - drug effects ; Gram-Negative Bacteria - physiology ; Gram-Positive Bacteria - drug effects ; Gram-Positive Bacteria - physiology ; Hydrogen peroxide ; Iodides ; Iodides - pharmacology ; Iodine ; Life Sciences ; Microbial Genetics and Genomics ; Microbial Viability - drug effects ; Microbiology ; Microorganisms ; Oxidation ; Oxidoreductases - isolation & purification ; Oxidoreductases - metabolism ; Oxidoreductases - pharmacology ; PVP ; Spores, Bacterial - drug effects ; Studies ; Time Factors</subject><ispartof>Applied microbiology and biotechnology, 2015-12, Vol.99 (23), p.10011-10018</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c602t-dc286540ad39e7555d9573c4698acb01955d04361f1e92cf1014277aaa156cec3</citedby><cites>FETCH-LOGICAL-c602t-dc286540ad39e7555d9573c4698acb01955d04361f1e92cf1014277aaa156cec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00253-015-6862-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00253-015-6862-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26254787$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yuliana, Tri</creatorcontrib><creatorcontrib>Ebihara, Kyota</creatorcontrib><creatorcontrib>Suzuki, Mio</creatorcontrib><creatorcontrib>Shimonaka, Chie</creatorcontrib><creatorcontrib>Amachi, Seigo</creatorcontrib><title>novel enzyme-based antimicrobial system comprising iodide and a multicopper oxidase isolated from Alphaproteobacterium strain Q-1</title><title>Applied microbiology and biotechnology</title><addtitle>Appl Microbiol Biotechnol</addtitle><addtitle>Appl Microbiol Biotechnol</addtitle><description>Alphaproteobacterium strain Q-1 produces an extracellular multicopper oxidase (IOX), which catalyzes iodide (I–) oxidation to form molecular iodine (I₂). In this study, the antimicrobial activity of the IOX/iodide system was determined. Both Gram-positive and Gram-negative bacteria tested were killed completely within 5 min by 50 mU mL–¹ of IOX and 10 mM iodide. The sporicidal activity of the system was also tested and compared with a common iodophor, povidone-iodine (PVP-I). IOX (300 mU mL–¹) killed Bacillus cereus, B. subtilis, and Geobacillus stearothermophilus spores with decimal reduction times of 2.58, 7.62, and 40.9 min, respectively. However, 0.1 % PVP-I killed these spores with much longer decimal reduction times of 5.46, 38.0, and 260 min, respectively. To evaluate the more superior sporicidal activity of the IOX system over PVP-I, the amount of free iodine (non-complexed I₂) was determined by an equilibrium dialysis technique. The IOX system included more than 40 mg L–¹ of free iodine, while PVP-I included at most 25 mg L–¹ free iodine. Our results suggest that the new enzyme-based antimicrobial system is effective against a wide variety of microorganisms and bacterial spores, and that its strong biocidal activity is due to its high free iodine content, which is probably maintained by re-oxidation of iodide released after oxidation of cell components by I₂.</description><subject>Alphaproteobacteria - enzymology</subject><subject>Alphaproteobacteria - metabolism</subject><subject>Analysis</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - metabolism</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>anti-infective properties</subject><subject>Antimicrobial agents</subject><subject>Bacillus cereus</subject><subject>Bacteria</subject><subject>bacterial spores</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnologically Relevant Enzymes and Proteins</subject><subject>Biotechnology</subject><subject>Cellular biology</subject><subject>Dialysis</subject><subject>Disinfection & disinfectants</subject><subject>E coli</subject><subject>Enzymes</subject><subject>Geobacillus</subject><subject>Geobacillus stearothermophilus</subject><subject>Gram-negative bacteria</subject><subject>Gram-Negative Bacteria - drug effects</subject><subject>Gram-Negative Bacteria - physiology</subject><subject>Gram-Positive Bacteria - drug effects</subject><subject>Gram-Positive Bacteria - physiology</subject><subject>Hydrogen peroxide</subject><subject>Iodides</subject><subject>Iodides - pharmacology</subject><subject>Iodine</subject><subject>Life Sciences</subject><subject>Microbial Genetics and Genomics</subject><subject>Microbial Viability - drug effects</subject><subject>Microbiology</subject><subject>Microorganisms</subject><subject>Oxidation</subject><subject>Oxidoreductases - isolation & purification</subject><subject>Oxidoreductases - metabolism</subject><subject>Oxidoreductases - pharmacology</subject><subject>PVP</subject><subject>Spores, Bacterial - drug effects</subject><subject>Studies</subject><subject>Time Factors</subject><issn>0175-7598</issn><issn>1432-0614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU-L1TAUxYMoznP0A7jRgBs31XvTJmmXw-A_GBDRWYc0TZ8ZmuaZtOJz5zf3PjqKuBCzSUh-99ybcxh7jPACAfTLAiBkXQHKSrVKVHCH7bCp6aCwuct2gFpWWnbtGXtQyg0Ailap--xMKCEb3eod-zGnr37ifv5-jL7qbfEDt_MSYnA59cFOvBzL4iN3KR5yKGHe85CGMHjCCOVxnZbg0uHgM0_fwkAKPJQ02YWUxpwiv5gOn-0hp8Wn3rrF57BGXpZsw8w_VPiQ3RvtVPyj2_2cXb9-9enybXX1_s27y4uryikQSzU4ml02YIe681pKOXRS165RXWtdD9jRDTS1whF9J9yIgI3Q2lqLUjnv6nP2fNOlUb6sviwmhuL8NNnZp7UY8goFqgbEf6B1jZ1QsiP02V_oTVrzTB85UULLFpuWKNwoMrWU7EdDXkabjwbBnKI0W5SGojSnKA1QzZNb5bWPfvhd8Ss7AsQGFHqa9z7_0fofqk-3otEmY_eUqLn-KAAV0JIgRP0TJAuy7w</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Yuliana, Tri</creator><creator>Ebihara, Kyota</creator><creator>Suzuki, Mio</creator><creator>Shimonaka, Chie</creator><creator>Amachi, Seigo</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>LK8</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>20151201</creationdate><title>novel enzyme-based antimicrobial system comprising iodide and a multicopper oxidase isolated from Alphaproteobacterium strain Q-1</title><author>Yuliana, Tri ; Ebihara, Kyota ; Suzuki, Mio ; Shimonaka, Chie ; Amachi, Seigo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c602t-dc286540ad39e7555d9573c4698acb01955d04361f1e92cf1014277aaa156cec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Alphaproteobacteria - 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Academic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>Applied microbiology and biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yuliana, Tri</au><au>Ebihara, Kyota</au><au>Suzuki, Mio</au><au>Shimonaka, Chie</au><au>Amachi, Seigo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>novel enzyme-based antimicrobial system comprising iodide and a multicopper oxidase isolated from Alphaproteobacterium strain Q-1</atitle><jtitle>Applied microbiology and biotechnology</jtitle><stitle>Appl Microbiol Biotechnol</stitle><addtitle>Appl Microbiol Biotechnol</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>99</volume><issue>23</issue><spage>10011</spage><epage>10018</epage><pages>10011-10018</pages><issn>0175-7598</issn><eissn>1432-0614</eissn><abstract>Alphaproteobacterium strain Q-1 produces an extracellular multicopper oxidase (IOX), which catalyzes iodide (I–) oxidation to form molecular iodine (I₂). In this study, the antimicrobial activity of the IOX/iodide system was determined. Both Gram-positive and Gram-negative bacteria tested were killed completely within 5 min by 50 mU mL–¹ of IOX and 10 mM iodide. The sporicidal activity of the system was also tested and compared with a common iodophor, povidone-iodine (PVP-I). IOX (300 mU mL–¹) killed Bacillus cereus, B. subtilis, and Geobacillus stearothermophilus spores with decimal reduction times of 2.58, 7.62, and 40.9 min, respectively. However, 0.1 % PVP-I killed these spores with much longer decimal reduction times of 5.46, 38.0, and 260 min, respectively. To evaluate the more superior sporicidal activity of the IOX system over PVP-I, the amount of free iodine (non-complexed I₂) was determined by an equilibrium dialysis technique. The IOX system included more than 40 mg L–¹ of free iodine, while PVP-I included at most 25 mg L–¹ free iodine. Our results suggest that the new enzyme-based antimicrobial system is effective against a wide variety of microorganisms and bacterial spores, and that its strong biocidal activity is due to its high free iodine content, which is probably maintained by re-oxidation of iodide released after oxidation of cell components by I₂.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26254787</pmid><doi>10.1007/s00253-015-6862-0</doi><tpages>8</tpages></addata></record> |
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| ispartof | Applied microbiology and biotechnology, 2015-12, Vol.99 (23), p.10011-10018 |
| issn | 0175-7598 1432-0614 |
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| subjects | Alphaproteobacteria - enzymology Alphaproteobacteria - metabolism Analysis Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology anti-infective properties Antimicrobial agents Bacillus cereus Bacteria bacterial spores Biomedical and Life Sciences Biotechnologically Relevant Enzymes and Proteins Biotechnology Cellular biology Dialysis Disinfection & disinfectants E coli Enzymes Geobacillus Geobacillus stearothermophilus Gram-negative bacteria Gram-Negative Bacteria - drug effects Gram-Negative Bacteria - physiology Gram-Positive Bacteria - drug effects Gram-Positive Bacteria - physiology Hydrogen peroxide Iodides Iodides - pharmacology Iodine Life Sciences Microbial Genetics and Genomics Microbial Viability - drug effects Microbiology Microorganisms Oxidation Oxidoreductases - isolation & purification Oxidoreductases - metabolism Oxidoreductases - pharmacology PVP Spores, Bacterial - drug effects Studies Time Factors |
| title | novel enzyme-based antimicrobial system comprising iodide and a multicopper oxidase isolated from Alphaproteobacterium strain Q-1 |
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