Ferroquine and artesunate in African adults and children with Plasmodium falciparum malaria: a phase 2, multicentre, randomised, double-blind, dose-ranging, non-inferiority study

Summary Background Artemisinin-based combination therapies (ACTs) are the recommended first-line treatment for uncomplicated Plasmodium falciparum malaria. Ferroquine is a new combination partner for fast-acting ACTs such as artesunate. We aimed to assess different doses of ferroquine in combination...

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Veröffentlicht in:	The Lancet infectious diseases 2015-12, Vol.15 (12), p.1409-1419
Hauptverfasser:	Held, Jana, PhD, Supan, Christian, MD, Salazar, Carmen L O, MD, Tinto, Halidou, PhD, Bonkian, Léa N, MSc, Nahum, Alain, PhD, Moulero, Bancole, MPH, Sié, Ali, PhD, Coulibaly, Boubacar, PhD, Sirima, Sodiomon B, PhD, Siribie, Mohamadou, PhD, Otsyula, Nekoye, MSc, Otieno, Lucas, MD, Abdallah, Ahmed M, MD, Kimutai, Robert, MD, Bouyou-Akotet, Marielle, Prof, Kombila, Maryvonne, Prof, Koiwai, Kimiko, MA, Cantalloube, Cathy, PharmD, Din-Bell, Chantal, MSc, Djeriou, Elhadj, Waitumbi, John, PhD, Mordmüller, Benjamin, MD, Ter-Minassian, Daniel, MD, Lell, Bertrand, MD, Kremsner, Peter G, Prof
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aminoquinolines - therapeutic use Antimalarials - therapeutic use Artemisinins - therapeutic use Body temperature Child Child, Preschool Double-Blind Method Drug Administration Schedule Drug dosages Drug Therapy, Combination Electrocardiography Female Ferrous Compounds - therapeutic use Humans Infectious Disease Infectious diseases Malaria Malaria, Falciparum - drug therapy Malaria, Falciparum - parasitology Malaria, Falciparum - pathology Male Middle Aged Parasites Pharmaceutical industry Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - physiology Studies Teenagers Treatment Outcome Vector-borne diseases
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