Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial

Summary Background Radiotherapy is the standard care in elderly patients with malignant astrocytoma and the role of primary chemotherapy is poorly defined. We did a randomised trial to compare the efficacy and safety of dose-dense temozolomide alone versus radiotherapy alone in elderly patients with...

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Veröffentlicht in:	The lancet oncology 2012-07, Vol.13 (7), p.707-715
Hauptverfasser:	Wick, Wolfgang, Prof, Platten, Michael, Prof, Meisner, Christoph, PhD, Felsberg, Jörg, MD, Tabatabai, Ghazaleh, MD, Simon, Matthias, MD, Nikkhah, Guido, Prof, Papsdorf, Kirsten, MD, Steinbach, Joachim P, Prof, Sabel, Michael, MD, Combs, Stephanie E, MD, Vesper, Jan, MD, Braun, Christian, MD, Meixensberger, Jürgen, Prof, Ketter, Ralf, MD, Mayer-Steinacker, Regine, MD, Reifenberger, Guido, Prof, Weller, Michael, Prof
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Antineoplastic Agents, Alkylating - therapeutic use Astrocytoma - drug therapy Astrocytoma - mortality Astrocytoma - radiotherapy Biopsy Brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - mortality Brain Neoplasms - radiotherapy Brain research Chemotherapy Dacarbazine - analogs & derivatives Dacarbazine - therapeutic use Disease-Free Survival DNA Methylation DNA Modification Methylases - genetics DNA Repair Enzymes - genetics Female Hematology, Oncology and Palliative Medicine Humans Isocitrate Dehydrogenase - genetics Male Medical prognosis Patients Promoter Regions, Genetic Radiation therapy Tumor Suppressor Proteins - genetics Tumors
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