Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial

Summary Background Since the introduction of breast-conserving treatment, various radiation doses after lumpectomy have been used. In a phase 3 randomised controlled trial, we investigated the effect of a radiation boost of 16 Gy on overall survival, local control, and fibrosis for patients with sta...

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Veröffentlicht in:	The lancet oncology 2015, Vol.16 (1), p.47-56
Hauptverfasser:	Bartelink, Harry, Dr, Maingon, Philippe, MD, Poortmans, Philip, MD, Weltens, Caroline, MD, Fourquet, Alain, MD, Jager, Jos, MD, Schinagl, Dominic, MD, Oei, Bing, MD, Rodenhuis, Carla, MD, Horiot, Jean-Claude, MD, Struikmans, Henk, MD, Van Limbergen, Erik, MD, Kirova, Youlia, MD, Elkhuizen, Paula, MD, Bongartz, Rudolf, MD, Miralbell, Raymond, MD, Morgan, David, MD, Dubois, Jean-Bernard, MD, Remouchamps, Vincent, MD, Mirimanoff, René-Olivier, MD, Collette, Sandra, MSc, Collette, Laurence, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Australia Breast cancer Breast Neoplasms - mortality Breast Neoplasms - pathology Breast Neoplasms - radiotherapy Breast Neoplasms - surgery Cancer therapies Dissection Europe Female Fibrosis Hematology, Oncology and Palliative Medicine Humans Intention to Treat Analysis Israel Kaplan-Meier Estimate Mastectomy Mastectomy, Segmental - adverse effects Mastectomy, Segmental - mortality Middle Aged Mortality Neoplasm Recurrence, Local Neoplasm Staging Patient Selection Proportional Hazards Models Radiation therapy Radiotherapy Dosage Radiotherapy, Adjuvant Reoperation Salvage Therapy Studies Time Factors Treatment Outcome
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