Crossreactive alpha beta T Cell Receptors Are the Predominant Targets of Thymocyte Negative Selection

The precise impact of thymic positive and negative selection on the T cell receptor (TCR) repertoire remains controversial. Here, we used unbiased, high-throughput cloning and retroviral expression of individual pre-selection TCRs to provide a direct assessment of these processes at the clonal level...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2015-11, Vol.43 (5), p.859-869
Hauptverfasser:	McDonald, Benjamin D, Bunker, Jeffrey J, Erickson, Steven A, Oh-Hora, Masatsugu, Bendelac, Albert
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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