Arsenic trioxide and all- trans retinoic acid treatment for acute promyelocytic leukaemia in all risk groups (AML17): results of a randomised, controlled, phase 3 trial

Summary Background Acute promyelocytic leukaemia is a chemotherapy-sensitive subgroup of acute myeloid leukaemia characterised by the presence of the PML–RARA fusion transcript. The present standard of care, chemotherapy and all- trans retinoic acid (ATRA), results in a high proportion of patients b...

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Veröffentlicht in:	The lancet oncology 2015-10, Vol.16 (13), p.1295-1305
Hauptverfasser:	Burnett, Alan K, Prof, Russell, Nigel H, Prof, Hills, Robert K, DPhil, Bowen, David, Prof, Kell, Jonathan, MD, Knapper, Steve, DM, Morgan, Yvonne G, PhD, Lok, Jennie, MSc, Grech, Angela, BA, Jones, Gail, MD, Khwaja, Asim, Prof, Friis, Lone, PhD, McMullin, Mary Frances, Prof, Hunter, Ann, MD, Clark, Richard E, Prof, Grimwade, David, Prof
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Adolescent Adult Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Arsenic Arsenicals - adverse effects Arsenicals - therapeutic use Biomarkers, Tumor - genetics Blood Chemotherapy Collaboration Cytotoxicity Denmark Female Hematology, Oncology and Palliative Medicine Humans Idarubicin - adverse effects Idarubicin - therapeutic use Intention to Treat Analysis Kaplan-Meier Estimate Leukemia Leukemia, Promyelocytic, Acute - diagnosis Leukemia, Promyelocytic, Acute - drug therapy Leukemia, Promyelocytic, Acute - genetics Leukemia, Promyelocytic, Acute - mortality Leukocyte Count Male Middle Aged Mortality New Zealand Oncogene Proteins, Fusion - genetics Oxides - adverse effects Oxides - therapeutic use Quality of Life Real-Time Polymerase Chain Reaction Regulatory approval Studies Time Factors Treatment Outcome Tretinoin - adverse effects Tretinoin - therapeutic use United Kingdom Young Adult
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