Inhibition of HSP90 molecular chaperones: moving into the clinic
Summary Heat shock protein 90 (HSP90) is a molecular chaperone that is crucial for the stability and function of many proteins essential for cell survival. Many oncogenes, including tyrosine kinases, transcription factors, and cell-cycle regulatory proteins, are client proteins of HSP90. Inhibition...
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Veröffentlicht in: | The lancet oncology 2013-08, Vol.14 (9), p.e358-e369 |
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description | Summary Heat shock protein 90 (HSP90) is a molecular chaperone that is crucial for the stability and function of many proteins essential for cell survival. Many oncogenes, including tyrosine kinases, transcription factors, and cell-cycle regulatory proteins, are client proteins of HSP90. Inhibition of HSP90 causes client protein degradation via the ubiquitin–proteasome pathway, and is a mechanism that might simultaneously downregulate several redundant pathways crucial for cell viability and tumour development. HSP90 inhibitors are currently being developed as anticancer agents, and have shown early promising results in molecularly defined subgroups of solid tumours (eg, ALK-rearranged non-small-cell lung cancer and HER2-amplified breast cancer) and some haematological malignancies (eg, multiple myeloma). Here, we review the current status of HSP90 inhibitors in clinical development, including geldanamycin derivatives, resorcinol derivatives, purine analogues, and other synthetic inhibitors. We also discuss novel strategies and future perspectives on how to optimise the therapeutic potential of this exciting new class of drugs. |
doi_str_mv | 10.1016/S1470-2045(13)70169-4 |
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Many oncogenes, including tyrosine kinases, transcription factors, and cell-cycle regulatory proteins, are client proteins of HSP90. Inhibition of HSP90 causes client protein degradation via the ubiquitin–proteasome pathway, and is a mechanism that might simultaneously downregulate several redundant pathways crucial for cell viability and tumour development. HSP90 inhibitors are currently being developed as anticancer agents, and have shown early promising results in molecularly defined subgroups of solid tumours (eg, ALK-rearranged non-small-cell lung cancer and HER2-amplified breast cancer) and some haematological malignancies (eg, multiple myeloma). Here, we review the current status of HSP90 inhibitors in clinical development, including geldanamycin derivatives, resorcinol derivatives, purine analogues, and other synthetic inhibitors. We also discuss novel strategies and future perspectives on how to optimise the therapeutic potential of this exciting new class of drugs.</description><identifier>ISSN: 1470-2045</identifier><identifier>EISSN: 1474-5488</identifier><identifier>DOI: 10.1016/S1470-2045(13)70169-4</identifier><identifier>PMID: 23896275</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Androgens ; Animals ; Antineoplastic Agents - therapeutic use ; Cancer therapies ; Cytotoxicity ; Drug dosages ; Heat shock proteins ; Hematology, Oncology and Palliative Medicine ; HSP90 Heat-Shock Proteins - antagonists & inhibitors ; Humans ; Kinases ; Leukemia ; Medical prognosis ; Metabolism ; Metabolites ; Molecular Chaperones - antagonists & inhibitors ; Neoplasms - drug therapy ; Toxicity ; Tumors</subject><ispartof>The lancet oncology, 2013-08, Vol.14 (9), p.e358-e369</ispartof><rights>Elsevier Ltd</rights><rights>2013 Elsevier Ltd</rights><rights>Copyright © 2013 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Aug 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-47d9b2e414f728ea1c8f4548d5ec85b4a49f15a822ed0f14376fa941524dedef3</citedby><cites>FETCH-LOGICAL-c533t-47d9b2e414f728ea1c8f4548d5ec85b4a49f15a822ed0f14376fa941524dedef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1412863256?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23896275$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garcia-Carbonero, Rocio, MD</creatorcontrib><creatorcontrib>Carnero, Amancio, PhD</creatorcontrib><creatorcontrib>Paz-Ares, Luis, Dr</creatorcontrib><title>Inhibition of HSP90 molecular chaperones: moving into the clinic</title><title>The lancet oncology</title><addtitle>Lancet Oncol</addtitle><description>Summary Heat shock protein 90 (HSP90) is a molecular chaperone that is crucial for the stability and function of many proteins essential for cell survival. Many oncogenes, including tyrosine kinases, transcription factors, and cell-cycle regulatory proteins, are client proteins of HSP90. Inhibition of HSP90 causes client protein degradation via the ubiquitin–proteasome pathway, and is a mechanism that might simultaneously downregulate several redundant pathways crucial for cell viability and tumour development. HSP90 inhibitors are currently being developed as anticancer agents, and have shown early promising results in molecularly defined subgroups of solid tumours (eg, ALK-rearranged non-small-cell lung cancer and HER2-amplified breast cancer) and some haematological malignancies (eg, multiple myeloma). Here, we review the current status of HSP90 inhibitors in clinical development, including geldanamycin derivatives, resorcinol derivatives, purine analogues, and other synthetic inhibitors. 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subjects | Androgens Animals Antineoplastic Agents - therapeutic use Cancer therapies Cytotoxicity Drug dosages Heat shock proteins Hematology, Oncology and Palliative Medicine HSP90 Heat-Shock Proteins - antagonists & inhibitors Humans Kinases Leukemia Medical prognosis Metabolism Metabolites Molecular Chaperones - antagonists & inhibitors Neoplasms - drug therapy Toxicity Tumors |
title | Inhibition of HSP90 molecular chaperones: moving into the clinic |
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