Relapsed childhood acute lymphoblastic leukaemia

Summary With steadily improved cure rates for children with newly diagnosed acute lymphoblastic leukaemia (ALL), treating relapsed ALL has become increasingly challenging largely due to resistance to salvage therapy. Improved biological understanding of mechanisms of relapse and drug resistance, the...

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Veröffentlicht in:	The lancet oncology 2013-05, Vol.14 (6), p.e205-e217
Hauptverfasser:	Bhojwani, Deepa, Dr, Pui, Ching-Hon, Prof
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age of Onset Animals Antineoplastic Agents - therapeutic use Cell cycle Child Child, Preschool Cloning DNA methylation Drug Design Drug resistance Drug Resistance, Neoplasm Epigenetics Female Genomes Hematology, Oncology and Palliative Medicine Hematopoietic Stem Cell Transplantation Humans Immunotherapy - methods Infant Kinases Leukemia Male Medical prognosis Molecular Targeted Therapy Mutation Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy Recurrence Risk Assessment Risk Factors Salvage Therapy Stem cells Time Factors Treatment Outcome Young Adult
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