Real-time tumour tracking in particle therapy: technological developments and future perspectives
Summary A key challenge in radiation oncology is accurate delivery of the prescribed dose to tumours that move because of respiration. Tumour tracking involves real-time target localisation and correction of radiation beam geometry to compensate for motion. Uncertainties in tumour localisation are i...
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| Veröffentlicht in: | The lancet oncology 2012-09, Vol.13 (9), p.e383-e391 |
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| container_end_page | e391 |
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| container_issue | 9 |
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| container_title | The lancet oncology |
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| creator | Riboldi, Marco, Dr Orecchia, Roberto, Prof Baroni, Guido, Prof |
| description | Summary A key challenge in radiation oncology is accurate delivery of the prescribed dose to tumours that move because of respiration. Tumour tracking involves real-time target localisation and correction of radiation beam geometry to compensate for motion. Uncertainties in tumour localisation are important in particle therapy (proton therapy, carbon-ion therapy) because charged particle beams are highly sensitive to geometrical and associated density and radiological variations in path length, which will affect the treatment plan. Target localisation and motion compensation methods applied in x-ray photon radiotherapy require careful performance assessment for clinical applications in particle therapy. In this Review, we summarise the efforts required for an application of real-time tumour tracking in particle therapy, by comparing and assessing competing strategies for time-resolved target localisation and related clinical outcomes in x-ray radiation oncology. |
| doi_str_mv | 10.1016/S1470-2045(12)70243-7 |
| format | Article |
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Tumour tracking involves real-time target localisation and correction of radiation beam geometry to compensate for motion. Uncertainties in tumour localisation are important in particle therapy (proton therapy, carbon-ion therapy) because charged particle beams are highly sensitive to geometrical and associated density and radiological variations in path length, which will affect the treatment plan. Target localisation and motion compensation methods applied in x-ray photon radiotherapy require careful performance assessment for clinical applications in particle therapy. In this Review, we summarise the efforts required for an application of real-time tumour tracking in particle therapy, by comparing and assessing competing strategies for time-resolved target localisation and related clinical outcomes in x-ray radiation oncology.</description><identifier>ISSN: 1470-2045</identifier><identifier>EISSN: 1474-5488</identifier><identifier>DOI: 10.1016/S1470-2045(12)70243-7</identifier><identifier>PMID: 22935238</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Cancer therapies ; Carbon ; Cell Tracking - methods ; Charged particles ; Fluoroscopy - methods ; Hematology, Oncology and Palliative Medicine ; Humans ; Liver ; Localization ; Lung cancer ; Medical prognosis ; Motion ; Neoplasms - diagnosis ; Neoplasms - pathology ; Neoplasms - radiotherapy ; Pancreas ; Planning ; Radiation Oncology - methods ; Radiation therapy ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted - methods ; Respiration ; Tumors</subject><ispartof>The lancet oncology, 2012-09, Vol.13 (9), p.e383-e391</ispartof><rights>Elsevier Ltd</rights><rights>2012 Elsevier Ltd</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-ea0fae9e1e7b98207ec8caf784f081a3e53176b34811664d5f8b245d83c5e6f3</citedby><cites>FETCH-LOGICAL-c514t-ea0fae9e1e7b98207ec8caf784f081a3e53176b34811664d5f8b245d83c5e6f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1470204512702437$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22935238$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Riboldi, Marco, Dr</creatorcontrib><creatorcontrib>Orecchia, Roberto, Prof</creatorcontrib><creatorcontrib>Baroni, Guido, Prof</creatorcontrib><title>Real-time tumour tracking in particle therapy: technological developments and future perspectives</title><title>The lancet oncology</title><addtitle>Lancet Oncol</addtitle><description>Summary A key challenge in radiation oncology is accurate delivery of the prescribed dose to tumours that move because of respiration. Tumour tracking involves real-time target localisation and correction of radiation beam geometry to compensate for motion. Uncertainties in tumour localisation are important in particle therapy (proton therapy, carbon-ion therapy) because charged particle beams are highly sensitive to geometrical and associated density and radiological variations in path length, which will affect the treatment plan. Target localisation and motion compensation methods applied in x-ray photon radiotherapy require careful performance assessment for clinical applications in particle therapy. In this Review, we summarise the efforts required for an application of real-time tumour tracking in particle therapy, by comparing and assessing competing strategies for time-resolved target localisation and related clinical outcomes in x-ray radiation oncology.</description><subject>Cancer therapies</subject><subject>Carbon</subject><subject>Cell Tracking - methods</subject><subject>Charged particles</subject><subject>Fluoroscopy - methods</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Liver</subject><subject>Localization</subject><subject>Lung cancer</subject><subject>Medical prognosis</subject><subject>Motion</subject><subject>Neoplasms - diagnosis</subject><subject>Neoplasms - pathology</subject><subject>Neoplasms - radiotherapy</subject><subject>Pancreas</subject><subject>Planning</subject><subject>Radiation Oncology - methods</subject><subject>Radiation therapy</subject><subject>Radiotherapy Dosage</subject><subject>Radiotherapy Planning, Computer-Assisted - methods</subject><subject>Respiration</subject><subject>Tumors</subject><issn>1470-2045</issn><issn>1474-5488</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkc1u1TAQRiMEoqXwCKBIbMoi1OOf2GFRhCqglSohQfeWrzNp3SZOsJ0r3bfHuSlU6oaubNlnvtHMKYq3QD4CgfrkF3BJKkq4OAb6QRLKWSWfFYf5mVeCK_V8f1-Rg-JVjLeEgAQiXhYHlDZMUKYOC_MTTV8lN2CZ5mGcQ5mCsXfOX5fOl5MJydk-_91gMNPuU5nQ3vixH6-dNX3Z4hb7cRrQp1ga35bdnOaA5YQhTmiT22J8XbzoTB_xzf15VFx9-3p1dl5d_vh-cfblsrICeKrQkM5gg4By0yhKJFplTScV74gCw1AwkPWGcQVQ17wVndpQLlrFrMC6Y0fF8Ro7hfH3jDHpwUWLfW88jnPUIAVQ0khVPxEFRZ-AEiZrUQvOMvr-EXqb1-nzyBqANXkiRRdKrJQNY4wBOz0FN5iwy1F6Eav3YvViTQPVe7Fa5rp39-nzZsD2X9Vfkxn4vAKYd7x1GHS0Dr3F1oVsQrej-2-L00cJtnd-8XyHO4wP0-hINVlDlgyg-wTJ_gCejsa8</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>Riboldi, Marco, Dr</creator><creator>Orecchia, Roberto, Prof</creator><creator>Baroni, Guido, Prof</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8C2</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20120901</creationdate><title>Real-time tumour tracking in particle therapy: technological developments and future perspectives</title><author>Riboldi, Marco, Dr ; 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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Cancer therapies Carbon Cell Tracking - methods Charged particles Fluoroscopy - methods Hematology, Oncology and Palliative Medicine Humans Liver Localization Lung cancer Medical prognosis Motion Neoplasms - diagnosis Neoplasms - pathology Neoplasms - radiotherapy Pancreas Planning Radiation Oncology - methods Radiation therapy Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted - methods Respiration Tumors |
| title | Real-time tumour tracking in particle therapy: technological developments and future perspectives |
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