SOX4 is overexpressed in diffusely infiltrating astrocytoma and confers poor prognosis
The SOX4 (sex‐determining region Y‐related high‐mobility‐group box transcription factor 4) gene plays critical roles in embryonic development and cell‐fate determination. Recently, SOX4 overexpression has been found in various tumors. However, its expression status and prognostic significance in ast...
Gespeichert in:
| Veröffentlicht in: | Neuropathology 2015-12, Vol.35 (6), p.510-517 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 517 |
|---|---|
| container_issue | 6 |
| container_start_page | 510 |
| container_title | Neuropathology |
| container_volume | 35 |
| creator | Li, Ling Li, Qiuyao Chen, Xueqin Xu, Miao Li, Xinglan Nie, Ling Chen, Ni Gong, Jing Mao, Qing Zhou, Qiao |
| description | The SOX4 (sex‐determining region Y‐related high‐mobility‐group box transcription factor 4) gene plays critical roles in embryonic development and cell‐fate determination. Recently, SOX4 overexpression has been found in various tumors. However, its expression status and prognostic significance in astrocytoma remain unknown. In this study, SOX4 expression in diffusely infiltrating astrocytoma (WHO grades II‐IV) tissues (in comparison with pilocytic astrocytomas) was examined by immunohistochemistry, and its relevance with prognosis was analyzed. Our data showed that SOX4 was over‐expressed in diffusely infiltrating astrocytomas and its expression was positively correlated with astrocytoma grade (WHO grades II‐IV). Significantly, Kaplan‐Meier analysis revealed that SOX4 nuclear overexpression (SOX4‐N) was associated with poorer progression‐free survival (PFS) and disease‐specific survival (DSS) in diffusely infiltrating astrocytoma patients (P |
| doi_str_mv | 10.1111/neup.12212 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1751208893</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3883757821</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5222-e8236e609ae3fa27a34bfaede6b5e7e512ea3fd242cc28af2de189389018cc3f3</originalsourceid><addsrcrecordid>eNqNkU1rFTEUhoMo9lrd-AMk4EYKU_M1-VhKaatQ2gu16i7kZk5K6tzJNJmxvf_eXG_bhQsxm0PgeZ-T8CL0lpJDWs_HAebxkDJG2TO0oEKQhiptnqMFMdQ0shViD70q5YYQqgzTL9Eek8RIaeQCfbu8-CFwLDj9ggz3Y4ZSoMNxwF0MYS7Qb-olxH7KborDNXZlyslvprR22A0d9mkIkAseU8p4zOl6SCWW1-hFcH2BNw9zH12dHH89-tycXZx-Ofp01viWMdaAZlxCfYwDHhxTjotVcNCBXLWgoKUMHA8dE8x7pl1gHVBtuDaEau954Pvow85bN9_OUCa7jsVD37sB0lwsVdVBdM38ByqElIwZVdH3f6E3ac5D_UiluNatoHorPNhRPqdSMgQ75rh2eWMpsdti7LYY-6eYCr97UM6rNXRP6GMTFaA74C72sPmHyp4fXy0fpc0uE8sE908Zl39aqbhq7ffzU3si-OWSkqVV_DcIkafv</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1738854183</pqid></control><display><type>article</type><title>SOX4 is overexpressed in diffusely infiltrating astrocytoma and confers poor prognosis</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Li, Ling ; Li, Qiuyao ; Chen, Xueqin ; Xu, Miao ; Li, Xinglan ; Nie, Ling ; Chen, Ni ; Gong, Jing ; Mao, Qing ; Zhou, Qiao</creator><creatorcontrib>Li, Ling ; Li, Qiuyao ; Chen, Xueqin ; Xu, Miao ; Li, Xinglan ; Nie, Ling ; Chen, Ni ; Gong, Jing ; Mao, Qing ; Zhou, Qiao</creatorcontrib><description>The SOX4 (sex‐determining region Y‐related high‐mobility‐group box transcription factor 4) gene plays critical roles in embryonic development and cell‐fate determination. Recently, SOX4 overexpression has been found in various tumors. However, its expression status and prognostic significance in astrocytoma remain unknown. In this study, SOX4 expression in diffusely infiltrating astrocytoma (WHO grades II‐IV) tissues (in comparison with pilocytic astrocytomas) was examined by immunohistochemistry, and its relevance with prognosis was analyzed. Our data showed that SOX4 was over‐expressed in diffusely infiltrating astrocytomas and its expression was positively correlated with astrocytoma grade (WHO grades II‐IV). Significantly, Kaplan‐Meier analysis revealed that SOX4 nuclear overexpression (SOX4‐N) was associated with poorer progression‐free survival (PFS) and disease‐specific survival (DSS) in diffusely infiltrating astrocytoma patients (P < 0.05). Cox regression analysis further showed that nuclear SOX4‐N was a significant independent negative prognostic factor for these patients.</description><identifier>ISSN: 0919-6544</identifier><identifier>EISSN: 1440-1789</identifier><identifier>DOI: 10.1111/neup.12212</identifier><identifier>PMID: 26096696</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; astrocytoma ; Astrocytoma - metabolism ; Astrocytoma - mortality ; Astrocytoma - pathology ; Biomarkers, Tumor - analysis ; Brain Neoplasms - metabolism ; Brain Neoplasms - mortality ; Brain Neoplasms - pathology ; Disease-Free Survival ; expression ; Female ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Male ; Medical prognosis ; Middle Aged ; Prognosis ; Proportional Hazards Models ; SOX4 ; SOXC Transcription Factors - analysis ; SOXC Transcription Factors - biosynthesis ; Up-Regulation ; Young Adult</subject><ispartof>Neuropathology, 2015-12, Vol.35 (6), p.510-517</ispartof><rights>2015 Japanese Society of Neuropathology</rights><rights>2015 Japanese Society of Neuropathology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5222-e8236e609ae3fa27a34bfaede6b5e7e512ea3fd242cc28af2de189389018cc3f3</citedby><cites>FETCH-LOGICAL-c5222-e8236e609ae3fa27a34bfaede6b5e7e512ea3fd242cc28af2de189389018cc3f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fneup.12212$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fneup.12212$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26096696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Ling</creatorcontrib><creatorcontrib>Li, Qiuyao</creatorcontrib><creatorcontrib>Chen, Xueqin</creatorcontrib><creatorcontrib>Xu, Miao</creatorcontrib><creatorcontrib>Li, Xinglan</creatorcontrib><creatorcontrib>Nie, Ling</creatorcontrib><creatorcontrib>Chen, Ni</creatorcontrib><creatorcontrib>Gong, Jing</creatorcontrib><creatorcontrib>Mao, Qing</creatorcontrib><creatorcontrib>Zhou, Qiao</creatorcontrib><title>SOX4 is overexpressed in diffusely infiltrating astrocytoma and confers poor prognosis</title><title>Neuropathology</title><addtitle>Neuropathology</addtitle><description>The SOX4 (sex‐determining region Y‐related high‐mobility‐group box transcription factor 4) gene plays critical roles in embryonic development and cell‐fate determination. Recently, SOX4 overexpression has been found in various tumors. However, its expression status and prognostic significance in astrocytoma remain unknown. In this study, SOX4 expression in diffusely infiltrating astrocytoma (WHO grades II‐IV) tissues (in comparison with pilocytic astrocytomas) was examined by immunohistochemistry, and its relevance with prognosis was analyzed. Our data showed that SOX4 was over‐expressed in diffusely infiltrating astrocytomas and its expression was positively correlated with astrocytoma grade (WHO grades II‐IV). Significantly, Kaplan‐Meier analysis revealed that SOX4 nuclear overexpression (SOX4‐N) was associated with poorer progression‐free survival (PFS) and disease‐specific survival (DSS) in diffusely infiltrating astrocytoma patients (P < 0.05). Cox regression analysis further showed that nuclear SOX4‐N was a significant independent negative prognostic factor for these patients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>astrocytoma</subject><subject>Astrocytoma - metabolism</subject><subject>Astrocytoma - mortality</subject><subject>Astrocytoma - pathology</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Brain Neoplasms - metabolism</subject><subject>Brain Neoplasms - mortality</subject><subject>Brain Neoplasms - pathology</subject><subject>Disease-Free Survival</subject><subject>expression</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>SOX4</subject><subject>SOXC Transcription Factors - analysis</subject><subject>SOXC Transcription Factors - biosynthesis</subject><subject>Up-Regulation</subject><subject>Young Adult</subject><issn>0919-6544</issn><issn>1440-1789</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1rFTEUhoMo9lrd-AMk4EYKU_M1-VhKaatQ2gu16i7kZk5K6tzJNJmxvf_eXG_bhQsxm0PgeZ-T8CL0lpJDWs_HAebxkDJG2TO0oEKQhiptnqMFMdQ0shViD70q5YYQqgzTL9Eek8RIaeQCfbu8-CFwLDj9ggz3Y4ZSoMNxwF0MYS7Qb-olxH7KborDNXZlyslvprR22A0d9mkIkAseU8p4zOl6SCWW1-hFcH2BNw9zH12dHH89-tycXZx-Ofp01viWMdaAZlxCfYwDHhxTjotVcNCBXLWgoKUMHA8dE8x7pl1gHVBtuDaEau954Pvow85bN9_OUCa7jsVD37sB0lwsVdVBdM38ByqElIwZVdH3f6E3ac5D_UiluNatoHorPNhRPqdSMgQ75rh2eWMpsdti7LYY-6eYCr97UM6rNXRP6GMTFaA74C72sPmHyp4fXy0fpc0uE8sE908Zl39aqbhq7ffzU3si-OWSkqVV_DcIkafv</recordid><startdate>201512</startdate><enddate>201512</enddate><creator>Li, Ling</creator><creator>Li, Qiuyao</creator><creator>Chen, Xueqin</creator><creator>Xu, Miao</creator><creator>Li, Xinglan</creator><creator>Nie, Ling</creator><creator>Chen, Ni</creator><creator>Gong, Jing</creator><creator>Mao, Qing</creator><creator>Zhou, Qiao</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201512</creationdate><title>SOX4 is overexpressed in diffusely infiltrating astrocytoma and confers poor prognosis</title><author>Li, Ling ; Li, Qiuyao ; Chen, Xueqin ; Xu, Miao ; Li, Xinglan ; Nie, Ling ; Chen, Ni ; Gong, Jing ; Mao, Qing ; Zhou, Qiao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5222-e8236e609ae3fa27a34bfaede6b5e7e512ea3fd242cc28af2de189389018cc3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>astrocytoma</topic><topic>Astrocytoma - metabolism</topic><topic>Astrocytoma - mortality</topic><topic>Astrocytoma - pathology</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Brain Neoplasms - metabolism</topic><topic>Brain Neoplasms - mortality</topic><topic>Brain Neoplasms - pathology</topic><topic>Disease-Free Survival</topic><topic>expression</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>SOX4</topic><topic>SOXC Transcription Factors - analysis</topic><topic>SOXC Transcription Factors - biosynthesis</topic><topic>Up-Regulation</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Ling</creatorcontrib><creatorcontrib>Li, Qiuyao</creatorcontrib><creatorcontrib>Chen, Xueqin</creatorcontrib><creatorcontrib>Xu, Miao</creatorcontrib><creatorcontrib>Li, Xinglan</creatorcontrib><creatorcontrib>Nie, Ling</creatorcontrib><creatorcontrib>Chen, Ni</creatorcontrib><creatorcontrib>Gong, Jing</creatorcontrib><creatorcontrib>Mao, Qing</creatorcontrib><creatorcontrib>Zhou, Qiao</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Ling</au><au>Li, Qiuyao</au><au>Chen, Xueqin</au><au>Xu, Miao</au><au>Li, Xinglan</au><au>Nie, Ling</au><au>Chen, Ni</au><au>Gong, Jing</au><au>Mao, Qing</au><au>Zhou, Qiao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SOX4 is overexpressed in diffusely infiltrating astrocytoma and confers poor prognosis</atitle><jtitle>Neuropathology</jtitle><addtitle>Neuropathology</addtitle><date>2015-12</date><risdate>2015</risdate><volume>35</volume><issue>6</issue><spage>510</spage><epage>517</epage><pages>510-517</pages><issn>0919-6544</issn><eissn>1440-1789</eissn><abstract>The SOX4 (sex‐determining region Y‐related high‐mobility‐group box transcription factor 4) gene plays critical roles in embryonic development and cell‐fate determination. Recently, SOX4 overexpression has been found in various tumors. However, its expression status and prognostic significance in astrocytoma remain unknown. In this study, SOX4 expression in diffusely infiltrating astrocytoma (WHO grades II‐IV) tissues (in comparison with pilocytic astrocytomas) was examined by immunohistochemistry, and its relevance with prognosis was analyzed. Our data showed that SOX4 was over‐expressed in diffusely infiltrating astrocytomas and its expression was positively correlated with astrocytoma grade (WHO grades II‐IV). Significantly, Kaplan‐Meier analysis revealed that SOX4 nuclear overexpression (SOX4‐N) was associated with poorer progression‐free survival (PFS) and disease‐specific survival (DSS) in diffusely infiltrating astrocytoma patients (P < 0.05). Cox regression analysis further showed that nuclear SOX4‐N was a significant independent negative prognostic factor for these patients.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>26096696</pmid><doi>10.1111/neup.12212</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0919-6544 |
| ispartof | Neuropathology, 2015-12, Vol.35 (6), p.510-517 |
| issn | 0919-6544 1440-1789 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1751208893 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult astrocytoma Astrocytoma - metabolism Astrocytoma - mortality Astrocytoma - pathology Biomarkers, Tumor - analysis Brain Neoplasms - metabolism Brain Neoplasms - mortality Brain Neoplasms - pathology Disease-Free Survival expression Female Humans Immunohistochemistry Kaplan-Meier Estimate Male Medical prognosis Middle Aged Prognosis Proportional Hazards Models SOX4 SOXC Transcription Factors - analysis SOXC Transcription Factors - biosynthesis Up-Regulation Young Adult |
| title | SOX4 is overexpressed in diffusely infiltrating astrocytoma and confers poor prognosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T19%3A46%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=SOX4%20is%20overexpressed%20in%20diffusely%20infiltrating%20astrocytoma%20and%20confers%20poor%20prognosis&rft.jtitle=Neuropathology&rft.au=Li,%20Ling&rft.date=2015-12&rft.volume=35&rft.issue=6&rft.spage=510&rft.epage=517&rft.pages=510-517&rft.issn=0919-6544&rft.eissn=1440-1789&rft_id=info:doi/10.1111/neup.12212&rft_dat=%3Cproquest_cross%3E3883757821%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1738854183&rft_id=info:pmid/26096696&rfr_iscdi=true |