Lactobacillus plantarum vaccine vector expressing hemagglutinin provides protection against H9N2 challenge infection

•IFN-γ cytokines, and CD107a+ producing CD3+CD8+ T cells in the spleen and MLN were induced by the NC8-pSIP409-HA-DCpep in mouse models.•NC8-pSIP409-HA-DCpep provided 100% protection against the mouse-adapted H9N2 virus (H9N2 m-AV) and reduced virus replication in the lungs after challenge with H9N2...

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Veröffentlicht in:	Virus research 2016-01, Vol.211, p.46-57
Hauptverfasser:	Shi, Shao-Hua, Yang, Wen-Tao, Yang, Gui-Lian, Zhang, Xu-Ke, Liu, Yu-Ying, Zhang, Li-Jiao, Ye, Li-Ping, Hu, Jing-Tao, Xin Xing, Qi, Chong, Li, Yu, Wang, Chun-Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - immunology Chickens Dendritic cell-targeting peptide Female Gene Expression Genetic Vectors - genetics Genetic Vectors - metabolism H9N2 influenza virus Hemagglutinin Hemagglutinin Glycoproteins, Influenza Virus - administration & dosage Hemagglutinin Glycoproteins, Influenza Virus - genetics Hemagglutinin Glycoproteins, Influenza Virus - immunology Influenza A Virus, H9N2 Subtype - genetics Influenza A Virus, H9N2 Subtype - immunology Influenza in Birds - immunology Influenza in Birds - prevention & control Influenza in Birds - virology Influenza Vaccines - administration & dosage Influenza Vaccines - genetics Influenza Vaccines - immunology Lactobacillus plantarum Lactobacillus plantarum - genetics Lactobacillus plantarum - metabolism Mice Mice, Inbred BALB C Mucosal vaccination Poultry Diseases - immunology Poultry Diseases - prevention & control Poultry Diseases - virology Vaccination
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