Alzheimer’s disease is associated with disordered localization of ganglioside GM1 molecular species in the human dentate gyrus

•We performed IMS analysis of ganglioside molecular species in the human hippocampus.•We observed a decrease of GM1 molecular species ratio in the outer ML of the DG in AD.•The disorder indicates a possible relation to dysfunction in AD. Alzheimer’s disease (AD) is a progressive dementia associated...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	FEBS letters 2015-11, Vol.589 (23), p.3611-3616
Hauptverfasser:	Hirano-Sakamaki, Wakako, Sugiyama, Eiji, Hayasaka, Takahiro, Ravid, Rivka, Setou, Mitsutoshi, Taki, Takao
Format:	Artikel
Sprache:	eng
Schlagworte:	2,5-dihydroxyacetophenone 9-AA 9-aminoacridine Aged, 80 and over Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease amyloid precursor protein amyloid β-protein APP Biological Transport cornu ammonis dentate gyrus Dentate Gyrus - metabolism Dentate Gyrus - pathology DHAP Female G(M1) Ganglioside - chemistry G(M1) Ganglioside - metabolism Ganglioside GM1 granular layer hematoxylin and eosin Hippocampus Humans Imaging mass spectrometry IMS Klüver–Barrera MALDI Male matrix-assisted laser desorption/ionization Middle Aged molecular layer Postmortem brain sulfatide time-of-flight TOF
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!