Preferential reduction of synaptic efficacy in the dentate gyrus of hippocampal slices from aged rats during reduced glucose availability

Highlights • Electrophysiology in dentate gyrus of hippocampal slices from adult and aged rats during reduced glucose exposure. • Slices from aged animals showed exacerbated reduction in synaptic response, suggesting impaired glucose utilization. • This exacerbated reduction in synaptic activity was...

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Veröffentlicht in:	Neuroscience 2015-10, Vol.307, p.262-272
Hauptverfasser:	Jones, R.T, Tyagi, I, Patrylo, P.R
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Analysis of Variance Animals dentate gyrus Dentate Gyrus - cytology Dose-Response Relationship, Drug Electric Stimulation Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology glucose Glucose - metabolism Glucose - pharmacology in vitro In Vitro Techniques Male metabolism Neurology Patch-Clamp Techniques Perforant Pathway - physiology Rats Rats, Inbred F344 synaptic transmission
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