Critical role of ARID3B in the expression of pro-apoptotic p53-target genes and apoptosis

ARID3A and ARID3B are transcriptional targets of p53. Recently, it has been reported that ARID3A plays a critical role in the transcriptional activation of pro-arrest p21 in response to DNA damage. However, the role of ARID3B in the p53 regulatory pathway remains poorly understood. Here we show that...

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Veröffentlicht in:	Biochemical and biophysical research communications 2015-12, Vol.468 (1-2), p.248-254
Hauptverfasser:	Pratama, Endrawan, Tian, Xiaohui, Lestari, Widya, Iseki, Sachiko, Ichwan, Solachuddin J.A., Ikeda, Masa-Aki
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis ARID3A ARID3B Cell Line, Tumor Cyclin-Dependent Kinase Inhibitor p21 - genetics DNA Damage DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene expression Gene Expression Regulation Gene Silencing Humans p53 Promoter Regions, Genetic Transcription Factors - genetics Transcription Factors - metabolism Transcriptional Activation Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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