Minimal extrathyroid extension in papillary thyroid carcinoma does not result in increased rates of either cause-specific mortality or postoperative tumor recurrence
Background This study assessed the influence of extrathyroid extension (EE) on cause-specific mortality (CSM) and tumor recurrence (TR) in patients treated for papillary thyroid carcinoma (PTC). Methods We studied outcome in 3,524 patients with PTC without distant metastases at diagnosis. CSM and TR...
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| creator | Hay, Ian D., MD, PhD Johnson, Tammi R., AS Thompson, Geoffrey B., MD Sebo, Thomas J., MD, PhD Reinalda, Megan S., BS |
| description | Background This study assessed the influence of extrathyroid extension (EE) on cause-specific mortality (CSM) and tumor recurrence (TR) in patients treated for papillary thyroid carcinoma (PTC). Methods We studied outcome in 3,524 patients with PTC without distant metastases at diagnosis. CSM and TR were investigated in 422 patients with gross EE (GEE) or microscopic EE (MEE). Results The 30-year CSM rate for GEE of 25% was 12-fold greater ( P < .001) than 2% seen with surgically intra-thyroid tumors (SIT); no patient who underwent MEE died of PTC. No difference ( P = .36) existed in CSM rates between 127 MEE and 3,102 microscopically intra-thyroid tumors (MITs). The 20-year TR rate for GEE was 43% versus 12% with SIT ( P < .001). Analyzing only 2,067 pN0 tumors, we found that GEE patients had greater TR rates (all sites), compared with SIT or MEE ( P 45 with tumors |
| doi_str_mv | 10.1016/j.surg.2015.05.046 |
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Methods We studied outcome in 3,524 patients with PTC without distant metastases at diagnosis. CSM and TR were investigated in 422 patients with gross EE (GEE) or microscopic EE (MEE). Results The 30-year CSM rate for GEE of 25% was 12-fold greater ( P < .001) than 2% seen with surgically intra-thyroid tumors (SIT); no patient who underwent MEE died of PTC. No difference ( P = .36) existed in CSM rates between 127 MEE and 3,102 microscopically intra-thyroid tumors (MITs). The 20-year TR rate for GEE was 43% versus 12% with SIT ( P < .001). Analyzing only 2,067 pN0 tumors, we found that GEE patients had greater TR rates (all sites), compared with SIT or MEE ( P < .001). When 44 MEE were compared with 1,941 MIT cases, TR (all sites) rates were not different ( P = .74). In patients aged >45 with tumors <41 mm, 20-year TR rates for MIT (stages I/II) and MEE (stage III) were not different at 4.7% and 3.8% ( P = .71). Conclusion MEE without concomitant GEE did not increase rates of either CSM or TR in PTC. Accordingly, these results raise concerns regarding current AJCC staging recommendations.</description><identifier>ISSN: 0039-6060</identifier><identifier>EISSN: 1532-7361</identifier><identifier>DOI: 10.1016/j.surg.2015.05.046</identifier><identifier>PMID: 26514317</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carcinoma - mortality ; Carcinoma - pathology ; Carcinoma - surgery ; Carcinoma, Papillary ; Child ; Child, Preschool ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local - mortality ; Neoplasm Recurrence, Local - pathology ; Prognosis ; Surgery ; Thyroid Cancer, Papillary ; Thyroid Neoplasms - mortality ; Thyroid Neoplasms - pathology ; Thyroid Neoplasms - surgery ; Treatment Outcome ; Young Adult</subject><ispartof>Surgery, 2016-01, Vol.159 (1), p.11-21</ispartof><rights>2016</rights><rights>Copyright © 2016. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-6f3e65a94e29f587f2158ea7249993e55b0f0d6b2f41615ca590f38a8b61027f3</citedby><cites>FETCH-LOGICAL-c525t-6f3e65a94e29f587f2158ea7249993e55b0f0d6b2f41615ca590f38a8b61027f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.surg.2015.05.046$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26514317$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hay, Ian D., MD, PhD</creatorcontrib><creatorcontrib>Johnson, Tammi R., AS</creatorcontrib><creatorcontrib>Thompson, Geoffrey B., MD</creatorcontrib><creatorcontrib>Sebo, Thomas J., MD, PhD</creatorcontrib><creatorcontrib>Reinalda, Megan S., BS</creatorcontrib><title>Minimal extrathyroid extension in papillary thyroid carcinoma does not result in increased rates of either cause-specific mortality or postoperative tumor recurrence</title><title>Surgery</title><addtitle>Surgery</addtitle><description>Background This study assessed the influence of extrathyroid extension (EE) on cause-specific mortality (CSM) and tumor recurrence (TR) in patients treated for papillary thyroid carcinoma (PTC). Methods We studied outcome in 3,524 patients with PTC without distant metastases at diagnosis. CSM and TR were investigated in 422 patients with gross EE (GEE) or microscopic EE (MEE). Results The 30-year CSM rate for GEE of 25% was 12-fold greater ( P < .001) than 2% seen with surgically intra-thyroid tumors (SIT); no patient who underwent MEE died of PTC. No difference ( P = .36) existed in CSM rates between 127 MEE and 3,102 microscopically intra-thyroid tumors (MITs). The 20-year TR rate for GEE was 43% versus 12% with SIT ( P < .001). Analyzing only 2,067 pN0 tumors, we found that GEE patients had greater TR rates (all sites), compared with SIT or MEE ( P < .001). When 44 MEE were compared with 1,941 MIT cases, TR (all sites) rates were not different ( P = .74). In patients aged >45 with tumors <41 mm, 20-year TR rates for MIT (stages I/II) and MEE (stage III) were not different at 4.7% and 3.8% ( P = .71). Conclusion MEE without concomitant GEE did not increase rates of either CSM or TR in PTC. Accordingly, these results raise concerns regarding current AJCC staging recommendations.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma - mortality</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma - surgery</subject><subject>Carcinoma, Papillary</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Recurrence, Local - mortality</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Prognosis</subject><subject>Surgery</subject><subject>Thyroid Cancer, Papillary</subject><subject>Thyroid Neoplasms - mortality</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid Neoplasms - surgery</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0039-6060</issn><issn>1532-7361</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uk2L1TAUDaI4b0b_gAvJ0k2fuWmTtiCCDOoIIy7UdchLb5w826Qm6TD9Qf5PU96MCxfChRDOB9xzLiEvgO2BgXx93Kcl_thzBmLPyjTyEdmBqHnV1hIekx1jdV9JJtkZOU_pyBjrG-iekjMuBTQ1tDvy-7PzbtIjxbscdb5ZY3DD9kGfXPDUeTrr2Y2jjit9gI2OxvkwaToETNSHTCOmZcwb3XkTUSccaPEraLAUXb7BWGRLwirNaJx1hk4hZj26vNIQ6RxSDjMWibtFmpcCFk-zxIje4DPyxOox4fP794J8__D-2-VVdf3l46fLd9eVEVzkStoapdB9g7y3omstB9GhbnnT932NQhyYZYM8cNuABGG06JmtO90dJDDe2vqCvDr5zjH8WjBlNblksGzvMSxJQSsA-hakLFR-opoYUopo1RxLkHFVwNRWjzqqrR611aNYmWYTvbz3Xw4TDn8lD30UwpsTAcuWtw6jSsZtCQyupJHVENz__d_-Izdj6dfo8SeumI5hib7kp0Alrpj6uh3Idh8gGGuha-s_KAm6ww</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Hay, Ian D., MD, PhD</creator><creator>Johnson, Tammi R., AS</creator><creator>Thompson, Geoffrey B., MD</creator><creator>Sebo, Thomas J., MD, PhD</creator><creator>Reinalda, Megan S., BS</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160101</creationdate><title>Minimal extrathyroid extension in papillary thyroid carcinoma does not result in increased rates of either cause-specific mortality or postoperative tumor recurrence</title><author>Hay, Ian D., MD, PhD ; Johnson, Tammi R., AS ; Thompson, Geoffrey B., MD ; Sebo, Thomas J., MD, PhD ; Reinalda, Megan S., BS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-6f3e65a94e29f587f2158ea7249993e55b0f0d6b2f41615ca590f38a8b61027f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma - mortality</topic><topic>Carcinoma - pathology</topic><topic>Carcinoma - surgery</topic><topic>Carcinoma, Papillary</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Recurrence, Local - mortality</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Prognosis</topic><topic>Surgery</topic><topic>Thyroid Cancer, Papillary</topic><topic>Thyroid Neoplasms - mortality</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hay, Ian D., MD, PhD</creatorcontrib><creatorcontrib>Johnson, Tammi R., AS</creatorcontrib><creatorcontrib>Thompson, Geoffrey B., MD</creatorcontrib><creatorcontrib>Sebo, Thomas J., MD, PhD</creatorcontrib><creatorcontrib>Reinalda, Megan S., BS</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hay, Ian D., MD, PhD</au><au>Johnson, Tammi R., AS</au><au>Thompson, Geoffrey B., MD</au><au>Sebo, Thomas J., MD, PhD</au><au>Reinalda, Megan S., BS</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Minimal extrathyroid extension in papillary thyroid carcinoma does not result in increased rates of either cause-specific mortality or postoperative tumor recurrence</atitle><jtitle>Surgery</jtitle><addtitle>Surgery</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>159</volume><issue>1</issue><spage>11</spage><epage>21</epage><pages>11-21</pages><issn>0039-6060</issn><eissn>1532-7361</eissn><abstract>Background This study assessed the influence of extrathyroid extension (EE) on cause-specific mortality (CSM) and tumor recurrence (TR) in patients treated for papillary thyroid carcinoma (PTC). Methods We studied outcome in 3,524 patients with PTC without distant metastases at diagnosis. CSM and TR were investigated in 422 patients with gross EE (GEE) or microscopic EE (MEE). Results The 30-year CSM rate for GEE of 25% was 12-fold greater ( P < .001) than 2% seen with surgically intra-thyroid tumors (SIT); no patient who underwent MEE died of PTC. No difference ( P = .36) existed in CSM rates between 127 MEE and 3,102 microscopically intra-thyroid tumors (MITs). The 20-year TR rate for GEE was 43% versus 12% with SIT ( P < .001). Analyzing only 2,067 pN0 tumors, we found that GEE patients had greater TR rates (all sites), compared with SIT or MEE ( P < .001). When 44 MEE were compared with 1,941 MIT cases, TR (all sites) rates were not different ( P = .74). In patients aged >45 with tumors <41 mm, 20-year TR rates for MIT (stages I/II) and MEE (stage III) were not different at 4.7% and 3.8% ( P = .71). Conclusion MEE without concomitant GEE did not increase rates of either CSM or TR in PTC. Accordingly, these results raise concerns regarding current AJCC staging recommendations.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26514317</pmid><doi>10.1016/j.surg.2015.05.046</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Carcinoma - mortality Carcinoma - pathology Carcinoma - surgery Carcinoma, Papillary Child Child, Preschool Female Humans Male Middle Aged Neoplasm Invasiveness Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology Prognosis Surgery Thyroid Cancer, Papillary Thyroid Neoplasms - mortality Thyroid Neoplasms - pathology Thyroid Neoplasms - surgery Treatment Outcome Young Adult |
| title | Minimal extrathyroid extension in papillary thyroid carcinoma does not result in increased rates of either cause-specific mortality or postoperative tumor recurrence |
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