Aggravating effect of atorvastatin on indomethacin-induced gastric injury: Focus on PGE2, TNF-α, neutrophils and iNOS

Statins are suggested to possess healing properties due to their antioxidant and antiinflammatory effects in animal ulcer models. In contrary, a clinical report indicated the formation of gastric ulcer by the use of atorvastatin. In this study, we aimed to investigate the effects of atorvastatin (0....

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Veröffentlicht in:	Prostaglandins & other lipid mediators 2015-09, Vol.121 (Pt A), p.53-62
Hauptverfasser:	Alp Yildirim, F. Ilkay, Uyanik, Özge, Özyoğurtçu, Hande, Gürel, Aydın, Atukeren, Pınar, Gümüştaş, Koray, Özdemir, Osman, Uydeş-Doğan, Sönmez
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidines - pharmacology Animals Atorvastatin Atorvastatin Calcium - pharmacology Benzylamines - pharmacology Dinoprostone - metabolism Drug Synergism Female Indomethacin - pharmacology Indomethacin-induced gastric ulcer iNOS Male Mevalonic Acid - pharmacology Neutrophil infiltration Neutrophil Infiltration - drug effects Neutrophils - drug effects Neutrophils - immunology Nitric Oxide Synthase Type II - metabolism PGE2 Rats Stomach Ulcer - chemically induced Stomach Ulcer - immunology Stomach Ulcer - metabolism TNF-a Tumor Necrosis Factor-alpha - metabolism
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