N-Stearoylethanolamine suppresses the pro-inflammatory cytokines production by inhibition of NF-κB translocation

•N-Stearoylethanolamine reduces IL-1 and IL-6 production in leukemic cells (L1210)•N-Stearoylethanolamine decreases IL-1 content in the medium of peritoneal macrophages stimulated by LPS.•N-Stearoylethanolamine normalizes TNF-α level in the serum of rats with obesity-induced insulin resistance.•N-St...

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Veröffentlicht in:	Prostaglandins & other lipid mediators 2015-09, Vol.121 (Pt A), p.91-96
Hauptverfasser:	Berdyshev, Andrey G., Kosiakova, Halyna V., Onopchenko, Oleksandra V., Panchuk, Rostislav R., Stoika, Rostislav S., Hula, Nadiya M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - drug effects Animals Anti-Inflammatory Agents - pharmacology Body Weight - drug effects Cell Line, Tumor Cell Nucleus - drug effects Cell Nucleus - metabolism Cytokines Cytokines - biosynthesis Cytokines - blood Cytokines - genetics Dose-Response Relationship, Drug Ethanolamines - pharmacology Inflammation Insulin - blood Insulin Resistance Lipopolysaccharides - pharmacology Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism Mice N-Acylethanolamines N-Stearoylethanolamine NF-kappa B - metabolism NF-kB Obesity - metabolism Rats RNA, Messenger - genetics RNA, Messenger - metabolism Stearic Acids - pharmacology
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