Impact of colonic mucosal lipoxin A4 synthesis capacity on healing in rats with dextran sodium sulfate-induced colitis

•Disease severity and mucosal lipoxin A4 synthesis were determined in rat colitis model.•5-Aminosalycylic had beneficial effects most prominent in the acute phase.•Misoprostol had favorable effects most marked in the healing phase.•Misoprostol caused a marked increase in mucosal lipoxin A4 synthesis...

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