UHPLC-MS/MS method with automated on-line solid phase extraction for the quantification of entecavir in peripheral blood mononuclear cells of HBV+ patients

To date five nucleoside analogs are used in the treatment of chronic hepatitis B: among these, entecavir is the most used. Nevertheless a few information about its distribution in tissues is currently known. Since the determination of entecavir disposition in the hepatocytes is impracticable because...

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Veröffentlicht in:Journal of pharmaceutical and biomedical analysis 2016-01, Vol.118, p.64-69
Hauptverfasser: De Nicolò, Amedeo, Bonifacio, Gabriele, Boglione, Lucio, Cusato, Jessica, Pensi, Debora, Tomasello, Cristina, Di Perri, Giovanni, D'Avolio, Antonio
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Sprache:eng
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