Insm1 controls the differentiation of pulmonary neuroendocrine cells by repressing Hes1

Epithelial progenitor cells of the lung generate all cell types of the mature airway epithelium, among them the neuroendocrine cells. The balance between formation of pulmonary neuroendocrine and non-neuroendocrine cells is controlled by Notch signaling. The Notch target gene Hes1 is expressed by no...

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Veröffentlicht in:	Developmental biology 2015-12, Vol.408 (1), p.90-98
Hauptverfasser:	Jia, Shiqi, Wildner, Hendrik, Birchmeier, Carmen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Cell Differentiation Cell Transdifferentiation DNA-Binding Proteins - metabolism Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Lung - cytology Mice, Mutant Strains Mutation - genetics Neuroendocrine Cells - cytology Neuroendocrine Cells - metabolism Protein Binding Repressor Proteins - metabolism Transcription Factor HES-1 Transcription Factors - metabolism
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