A three-drug nanoscale drug delivery system designed for preferential lymphatic uptake for the treatment of metastatic melanoma

Metastatic melanoma has a high mortality rate due to lymphatic progression of the disease. Current treatment is surgery followed by radiation and intravenous chemotherapy. However, drawbacks for current chemotherapeutics lie in the fact that they develop resistance and do not achieve therapeutic con...

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Veröffentlicht in:	Journal of controlled release 2015-12, Vol.220 (Pt A), p.503-514
Hauptverfasser:	Doddapaneni, Bhuvana S., Kyryachenko, Sergiy, Chagani, Sharmeen E., Alany, Raid G., Rao, Deepa A., Indra, Arup K., Alani, Adam W.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - chemistry Antineoplastic Combined Chemotherapy Protocols - metabolism Cell Line, Tumor Cell Survival - drug effects Chromones - administration & dosage Chromones - chemistry Chromones - metabolism Combination therapy Drug Carriers Drug Compounding Drug Resistance, Neoplasm Everolimus - administration & dosage Everolimus - chemistry Everolimus - metabolism Humans Lactones - chemistry Lymph Nodes - drug effects Lymph Nodes - metabolism Lymph Nodes - pathology Lymphatic drug delivery Melanocytes - drug effects Melanocytes - pathology Melanoma - drug therapy Melanoma - genetics Melanoma - metabolism Melanoma - secondary Melanoma transgenic mouse model Melanoma treatment Mice, Transgenic Morpholines - administration & dosage Morpholines - chemistry Morpholines - metabolism Nanoparticles Nanotechnology Polyethylene Glycols - chemistry Skin Neoplasms - drug therapy Skin Neoplasms - genetics Skin Neoplasms - metabolism Skin Neoplasms - pathology Solubility Surface Properties Taxoids - administration & dosage Taxoids - chemistry Taxoids - metabolism Time Factors Tumor Burden - drug effects
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