Bacteriomimetic invasin-functionalized nanocarriers for intracellular delivery

Intracellular bacteria invade mammalian cells to establish an infectious niche. The current work models adhesion and subsequent internalization strategy of pathogenic bacteria into mammalian cells to design a bacteriomimetic bioinvasive delivery system. We report on the surface functionalization of...

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Veröffentlicht in:	Journal of controlled release 2015-12, Vol.220 (Pt A), p.414-424
Hauptverfasser:	Labouta, Hagar Ibrahim, Menina, Sara, Kochut, Annika, Gordon, Sarah, Geyer, Rebecca, Dersch, Petra, Lehr, Claus-Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins, Bacterial - chemistry Adhesins, Bacterial - metabolism Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Bacterial Adhesion Bacterial Load - drug effects Bacteriomimetic liposomes Bioinvasive carriers Biological Transport Biomimetics Caco-2 Cells Cell Membrane - drug effects Cell Membrane - metabolism Cell Membrane - microbiology Cell uptake kinetics Drug Carriers Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - microbiology Gentamicins - chemistry Gentamicins - metabolism Gentamicins - pharmacology Humans Integrin beta1 Intracellular delivery Kinetics Liposomes Nanoparticles Nanotechnology Peptide Fragments - chemistry Peptide Fragments - metabolism Receptor competition experiments Yersinia pseudotuberculosis - drug effects Yersinia pseudotuberculosis - metabolism Yersinia pseudotuberculosis - pathogenicity
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