New polymorphs of 9-nitro-camptothecin prepared using a supercritical anti-solvent process

[Display omitted] •Recrystallization and micronization of 9-NC has been investigated via the SAS process using different type of organic solvents.•Three new polymorphic forms (Form II, III and IV) of 9-NC, which present different physicochemical properties, were generated after the SAS process.•It w...

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Veröffentlicht in:	International journal of pharmaceutics 2015-12, Vol.496 (2), p.551-560
Hauptverfasser:	Huang, Yinxia, Wang, Hongdi, Liu, Guijin, Jiang, Yanbin
Format:	Artikel
Sprache:	eng
Schlagworte:	9-Nitro-camptothecin Antineoplastic Agents - chemistry Camptothecin - analogs & derivatives Camptothecin - chemistry Cytotoxicity Micronization Particle Size Physicochemical properties Polymorph solvent Solvents Supercritical anti-solvent process
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