The Stem Cell Population of Arabidopsis Shoot Meristems Is Maintained by a Regulatory Loop between the CLAVATA and WUSCHEL Genes
The higher-plant shoot meristem is a dynamic structure whose maintenance depends on the coordination of two antagonistic processes, organ initiation and self-renewal of the stem cell population. In Arabidopsis shoot and floral meristems, the WUSCHEL ( WUS) gene is required for stem cell identity, wh...
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| Veröffentlicht in: | Cell 2000-03, Vol.100 (6), p.635-644 |
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| creator | Schoof, Heiko Lenhard, Michael Haecker, Achim Mayer, Klaus F.X Jürgens, Gerd Laux, Thomas |
| description | The higher-plant shoot meristem is a dynamic structure whose maintenance depends on the coordination of two antagonistic processes, organ initiation and self-renewal of the stem cell population. In
Arabidopsis shoot and floral meristems, the
WUSCHEL (
WUS) gene is required for stem cell identity, whereas the
CLAVATA1,
2, and
3 (
CLV) genes promote organ initiation. Our analysis of the interactions between these key regulators indicates that (1) the
CLV genes repress
WUS at the transcript level and that (2)
WUS expression is sufficient to induce meristem cell identity and the expression of the stem cell marker
CLV3. Our data suggest that the shoot meristem has properties of a self-regulatory system in which
WUS/
CLV interactions establish a feedback loop between the stem cells and the underlying organizing center. |
| doi_str_mv | 10.1016/S0092-8674(00)80700-X |
| format | Article |
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Arabidopsis shoot and floral meristems, the
WUSCHEL (
WUS) gene is required for stem cell identity, whereas the
CLAVATA1,
2, and
3 (
CLV) genes promote organ initiation. Our analysis of the interactions between these key regulators indicates that (1) the
CLV genes repress
WUS at the transcript level and that (2)
WUS expression is sufficient to induce meristem cell identity and the expression of the stem cell marker
CLV3. Our data suggest that the shoot meristem has properties of a self-regulatory system in which
WUS/
CLV interactions establish a feedback loop between the stem cells and the underlying organizing center.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/S0092-8674(00)80700-X</identifier><identifier>PMID: 10761929</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Arabidopsis ; Arabidopsis - cytology ; Arabidopsis - enzymology ; Arabidopsis - genetics ; Arabidopsis Proteins ; CLAVATA gene ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Plant ; Homeodomain Proteins - genetics ; Homeodomain Proteins - metabolism ; In Situ Hybridization ; Membrane Proteins - genetics ; Membrane Proteins - metabolism ; Meristem - enzymology ; Meristem - ultrastructure ; Microscopy, Electron, Scanning ; Mutagenesis - physiology ; Phenotype ; Plant Proteins - genetics ; Plant Proteins - metabolism ; Protein-Serine-Threonine Kinases ; Receptor Protein-Tyrosine Kinases - genetics ; Receptor Protein-Tyrosine Kinases - metabolism ; RNA, Messenger - analysis ; Seeds - cytology ; Seeds - physiology ; Transgenes - physiology ; WUSCHEL gene</subject><ispartof>Cell, 2000-03, Vol.100 (6), p.635-644</ispartof><rights>2000 Cell Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c557t-c616bd6e85373f57538f14896030d4655ab99d92d98050558d8ea02898c7978c3</citedby><cites>FETCH-LOGICAL-c557t-c616bd6e85373f57538f14896030d4655ab99d92d98050558d8ea02898c7978c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0092-8674(00)80700-X$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10761929$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schoof, Heiko</creatorcontrib><creatorcontrib>Lenhard, Michael</creatorcontrib><creatorcontrib>Haecker, Achim</creatorcontrib><creatorcontrib>Mayer, Klaus F.X</creatorcontrib><creatorcontrib>Jürgens, Gerd</creatorcontrib><creatorcontrib>Laux, Thomas</creatorcontrib><title>The Stem Cell Population of Arabidopsis Shoot Meristems Is Maintained by a Regulatory Loop between the CLAVATA and WUSCHEL Genes</title><title>Cell</title><addtitle>Cell</addtitle><description>The higher-plant shoot meristem is a dynamic structure whose maintenance depends on the coordination of two antagonistic processes, organ initiation and self-renewal of the stem cell population. In
Arabidopsis shoot and floral meristems, the
WUSCHEL (
WUS) gene is required for stem cell identity, whereas the
CLAVATA1,
2, and
3 (
CLV) genes promote organ initiation. Our analysis of the interactions between these key regulators indicates that (1) the
CLV genes repress
WUS at the transcript level and that (2)
WUS expression is sufficient to induce meristem cell identity and the expression of the stem cell marker
CLV3. Our data suggest that the shoot meristem has properties of a self-regulatory system in which
WUS/
CLV interactions establish a feedback loop between the stem cells and the underlying organizing center.</description><subject>Arabidopsis</subject><subject>Arabidopsis - cytology</subject><subject>Arabidopsis - enzymology</subject><subject>Arabidopsis - genetics</subject><subject>Arabidopsis Proteins</subject><subject>CLAVATA gene</subject><subject>Gene Expression Regulation, Enzymologic</subject><subject>Gene Expression Regulation, Plant</subject><subject>Homeodomain Proteins - genetics</subject><subject>Homeodomain Proteins - metabolism</subject><subject>In Situ Hybridization</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - metabolism</subject><subject>Meristem - enzymology</subject><subject>Meristem - ultrastructure</subject><subject>Microscopy, Electron, Scanning</subject><subject>Mutagenesis - physiology</subject><subject>Phenotype</subject><subject>Plant Proteins - genetics</subject><subject>Plant Proteins - metabolism</subject><subject>Protein-Serine-Threonine Kinases</subject><subject>Receptor Protein-Tyrosine Kinases - genetics</subject><subject>Receptor Protein-Tyrosine Kinases - metabolism</subject><subject>RNA, Messenger - analysis</subject><subject>Seeds - cytology</subject><subject>Seeds - physiology</subject><subject>Transgenes - physiology</subject><subject>WUSCHEL gene</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFu1DAQhi1ERZfSRwD5hOCQMk7i2D6hKCptpVQgdlt6s5x4Qo1249T2gvbGo5PtVogbh9Fcvn9-zUfIawZnDFj1YQmg8kxWonwH8F6CAMjunpEFAyWykon8OVn8RY7Jyxh_AIDknL8gxwxExVSuFuT36h7pMuGGNrhe0y9-2q5Ncn6kfqB1MJ2zfoou0uW994leY3BxpiO9ivTauDHNg5Z2O2roV_y-D_uwo633E-0w_UIcaZormra-rVc1NaOl326WzeV5Sy9wxPiKHA1mHfH0aZ-Qm0_nq-Yyaz9fXDV1m_Wci5T1Fas6W6HkhSgGLnghB1ZKVUEBtqw4N51SVuVWSeDAubQSDeRSyV4oIfvihLw93J2Cf9hiTHrjYj__bEb026iZ4AxKns8gP4B98DEGHPQU3MaEnWag9-r1o3q996oB9KN6fTfn3jwVbLsN2n9SB9cz8PEA4PzmT4dBx97h2KN1AfukrXf_qfgDK-KRqA</recordid><startdate>20000317</startdate><enddate>20000317</enddate><creator>Schoof, Heiko</creator><creator>Lenhard, Michael</creator><creator>Haecker, Achim</creator><creator>Mayer, Klaus F.X</creator><creator>Jürgens, Gerd</creator><creator>Laux, Thomas</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20000317</creationdate><title>The Stem Cell Population of Arabidopsis Shoot Meristems Is Maintained by a Regulatory Loop between the CLAVATA and WUSCHEL Genes</title><author>Schoof, Heiko ; Lenhard, Michael ; Haecker, Achim ; Mayer, Klaus F.X ; Jürgens, Gerd ; Laux, Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c557t-c616bd6e85373f57538f14896030d4655ab99d92d98050558d8ea02898c7978c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Arabidopsis</topic><topic>Arabidopsis - cytology</topic><topic>Arabidopsis - enzymology</topic><topic>Arabidopsis - genetics</topic><topic>Arabidopsis Proteins</topic><topic>CLAVATA gene</topic><topic>Gene Expression Regulation, Enzymologic</topic><topic>Gene Expression Regulation, Plant</topic><topic>Homeodomain Proteins - genetics</topic><topic>Homeodomain Proteins - metabolism</topic><topic>In Situ Hybridization</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - metabolism</topic><topic>Meristem - enzymology</topic><topic>Meristem - ultrastructure</topic><topic>Microscopy, Electron, Scanning</topic><topic>Mutagenesis - physiology</topic><topic>Phenotype</topic><topic>Plant Proteins - genetics</topic><topic>Plant Proteins - metabolism</topic><topic>Protein-Serine-Threonine Kinases</topic><topic>Receptor Protein-Tyrosine Kinases - genetics</topic><topic>Receptor Protein-Tyrosine Kinases - metabolism</topic><topic>RNA, Messenger - analysis</topic><topic>Seeds - cytology</topic><topic>Seeds - physiology</topic><topic>Transgenes - physiology</topic><topic>WUSCHEL gene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schoof, Heiko</creatorcontrib><creatorcontrib>Lenhard, Michael</creatorcontrib><creatorcontrib>Haecker, Achim</creatorcontrib><creatorcontrib>Mayer, Klaus F.X</creatorcontrib><creatorcontrib>Jürgens, Gerd</creatorcontrib><creatorcontrib>Laux, Thomas</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schoof, Heiko</au><au>Lenhard, Michael</au><au>Haecker, Achim</au><au>Mayer, Klaus F.X</au><au>Jürgens, Gerd</au><au>Laux, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Stem Cell Population of Arabidopsis Shoot Meristems Is Maintained by a Regulatory Loop between the CLAVATA and WUSCHEL Genes</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>2000-03-17</date><risdate>2000</risdate><volume>100</volume><issue>6</issue><spage>635</spage><epage>644</epage><pages>635-644</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><abstract>The higher-plant shoot meristem is a dynamic structure whose maintenance depends on the coordination of two antagonistic processes, organ initiation and self-renewal of the stem cell population. In
Arabidopsis shoot and floral meristems, the
WUSCHEL (
WUS) gene is required for stem cell identity, whereas the
CLAVATA1,
2, and
3 (
CLV) genes promote organ initiation. Our analysis of the interactions between these key regulators indicates that (1) the
CLV genes repress
WUS at the transcript level and that (2)
WUS expression is sufficient to induce meristem cell identity and the expression of the stem cell marker
CLV3. Our data suggest that the shoot meristem has properties of a self-regulatory system in which
WUS/
CLV interactions establish a feedback loop between the stem cells and the underlying organizing center.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>10761929</pmid><doi>10.1016/S0092-8674(00)80700-X</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Arabidopsis Arabidopsis - cytology Arabidopsis - enzymology Arabidopsis - genetics Arabidopsis Proteins CLAVATA gene Gene Expression Regulation, Enzymologic Gene Expression Regulation, Plant Homeodomain Proteins - genetics Homeodomain Proteins - metabolism In Situ Hybridization Membrane Proteins - genetics Membrane Proteins - metabolism Meristem - enzymology Meristem - ultrastructure Microscopy, Electron, Scanning Mutagenesis - physiology Phenotype Plant Proteins - genetics Plant Proteins - metabolism Protein-Serine-Threonine Kinases Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism RNA, Messenger - analysis Seeds - cytology Seeds - physiology Transgenes - physiology WUSCHEL gene |
| title | The Stem Cell Population of Arabidopsis Shoot Meristems Is Maintained by a Regulatory Loop between the CLAVATA and WUSCHEL Genes |
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