Genotoxicity of inorganic mercury salts based on disturbed microtubule function

This study investigated the hypothesis that the chromosomal genotoxicity of inorganic mercury results from interaction(s) with cytoskeletal proteins. Effects of Hg2+ salts on functional activities of tubulin and kinesin were investigated by determining tubulin assembly and kinesin-driven motility in...

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Veröffentlicht in:	Archives of toxicology 2004-10, Vol.78 (10), p.575-583
Hauptverfasser:	BONACKER, Daniela, STOIBER, Thomas, MINSHENG WANG, BÖHM, Konrad J, PROTS, Irina, UNGER, Eberhard, THIER, Ricarda, BOLT, Hermann M, DEGEN, Gisela H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Survival - drug effects Cells, Cultured - drug effects Cells, Cultured - pathology Chemical and industrial products toxicology. Toxic occupational diseases Chromosomes - drug effects Cricetinae Cricetulus Cytoskeleton Dose-Response Relationship, Drug Fibroblasts - drug effects Fibroblasts - pathology Investigations Kinesin - drug effects Kinesin - metabolism Medical sciences Mercuric Chloride - toxicity Metals and various inorganic compounds Micronuclei, Chromosome-Defective - chemically induced Micronucleus Tests Microscopy, Video Microtubule Proteins - metabolism Microtubule Proteins - ultrastructure Microtubules - drug effects Microtubules - metabolism Molecular Motor Proteins - drug effects Molecular Motor Proteins - metabolism Mutagenesis - drug effects Mutagenesis - genetics Mutagens - toxicity No-Observed-Adverse-Effect Level Proteins Toxicology Tubulin - drug effects Tubulin - metabolism
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