High Density Lipoprotein Deficiency and Foam Cell Accumulation in Mice with Targeted Disruption of ATP-Binding Cassette Transporter-1

Recently, the human ATP-binding cassette transporter-1 (ABC1) gene has been demonstrated to be mutated in patients with Tangier disease. To investigate the role of the ABC1 protein in an experimental in vivo model, we used gene targeting in DBA-1J embryonic stem cells to produce an ABC1-deficient mo...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2000-04, Vol.97 (8), p.4245-4250
Hauptverfasser:	McNeish, John, Aiello, Robert J., Guyot, Deborah, Turi, Tom, Gabel, Christopher, Aldinger, Charles, Hoppe, Kenneth L., Roach, Marsha L., Royer, Lori J., de Wet, Jeffrey, Broccardo, Cyril, Chimini, Giovanna, Francone, Omar L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abc1 gene Animals apolipoprotein A-I ATP Binding Cassette Transporter 1 ATP-Binding Cassette Transporters - genetics Base Sequence Biological Sciences Cholesterol - blood Cholesterols DNA Primers Foam cells Foam Cells - cytology Glycoproteins - genetics HDL lipoproteins Humans Lipids Lipoproteins Lipoproteins, HDL - blood Lipoproteins, HDL - deficiency Lungs Medical research Mice Mice, Knockout Mutation Phospholipids Pneumocytes Rodents Tangier disease
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