Curcuminoids Inhibit the Angiogenic Response Stimulated by Fibroblast Growth Factor-2, Including Expression of Matrix Metalloproteinase Gelatinase B

We have studied mechanisms controlling activation of the gelatinase B gene (matrix metalloproteinase-9) by fibroblast growth factor-2 (FGF-2) during angiogenesis, and the effects of the natural product curcuminoids on this process. Using a transgenic mouse (line 3445) harboring a gelatinase B promot...

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Veröffentlicht in:	The Journal of biological chemistry 2000-04, Vol.275 (14), p.10405-10412
Hauptverfasser:	Mohan, Royce, Sivak, Jeremy, Ashton, Paul, Russo, Laoti A., Pham, Bao Q., Kasahara, Niro, Raizman, Michael B., Fini, M.Elizabeth
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - administration & dosage Angiogenesis Inhibitors - pharmacology Animals beta-Galactosidase - genetics Cells, Cultured Cornea - blood supply Curcumin - administration & dosage Curcumin - pharmacology Curcuminoids Diet Female Fibroblast Growth Factor 2 - pharmacology Gene Expression Regulation, Enzymologic - drug effects Genes, Reporter lacZ gene Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Mice Mice, Transgenic Neovascularization, Pathologic - chemically induced Neovascularization, Pathologic - pathology Neovascularization, Pathologic - prevention & control NF-B protein NF-kappa B - metabolism Promoter Regions, Genetic Rabbits Recombinant Fusion Proteins - biosynthesis Recombinant Fusion Proteins - genetics Transcription Factor AP-1 - metabolism
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