Additional N-Glycosylation and Its Impact on the Folding of Intestinal Lactase-phlorizin Hydrolase

Lactase-phlorizin hydrolase (LPH) is a membrane bound intestinal hydrolase, with an extracellular domain comprising 4 homologous regions. LPH is synthesized as a large polypeptide precursor, pro-LPH, that undergoes several intra- and extracellular proteolytic steps to generate the final brush-border...

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Veröffentlicht in:	The Journal of biological chemistry 2000-04, Vol.275 (14), p.10630-10637
Hauptverfasser:	Jacob, Ralf, Weiner, Jocelyn R., Stadge, Stephanie, Naim, Hassan Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals COS Cells Dimerization Enzyme Precursors - chemistry Enzyme Precursors - genetics Genes, Reporter Glycosylation Green Fluorescent Proteins Humans Intestinal Mucosa - enzymology Lactase-phlorizin hydrolase Lactase-Phlorizin Hydrolase - chemistry Lactase-Phlorizin Hydrolase - metabolism Luminescent Proteins - genetics Microvilli - enzymology Mutagenesis, Site-Directed Protein Folding Recombinant Fusion Proteins - biosynthesis Recombinant Proteins - chemistry Recombinant Proteins - metabolism Transfection Trypsin
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