Regional recurrence in the era of sentinel lymph node biopsy
Abstract Background The incidence of all-location regional recurrence after sentinel lymph node biopsy is not well documented. This study attempts to identify risk factors. Methods A prospectively maintained database was queried to identify patients with a regional recurrence of breast cancer after...
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| Veröffentlicht in: | The American journal of surgery 2015-12, Vol.210 (6), p.1155-1161 |
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| creator | Linnaus, Maria E., M.D Dueck, Amylou C., Ph.D Kosiorek, Heidi E., M.S Gray, Richard J., M.D Wasif, Nabil, M.D Northfelt, Donald W., M.D Anderson, Karen S., M.D., Ph.D McCullough, Ann E., M.D Wong, William W., M.D Halyard, Michele Y., M.D Patel, Samir H., M.D Pockaj, Barbara A., M.D |
| description | Abstract Background The incidence of all-location regional recurrence after sentinel lymph node biopsy is not well documented. This study attempts to identify risk factors. Methods A prospectively maintained database was queried to identify patients with a regional recurrence of breast cancer after a first operation for invasive unilateral breast cancer. Patients with regional recurrence were compared with those alive and disease free at 5 years. Results Twenty-one of 1,060 patients (2%) experienced a regional recurrence. Most patients (95%) underwent sentinel lymph node biopsy as their axillary staging. Those with regional recurrences had larger tumors ( P < .001), higher stage disease ( P < .001), more estrogen receptor– and triple-negative breast cancers ( P < .001), and more positive lymph nodes ( P = .007). Mastectomy ( P = .001) and receipt of neoadjuvant and/or chemotherapy ( P < .001) were more common among those with regional recurrences. Conclusions Regional recurrence of breast cancer occurs infrequently. Risk factors include high-risk cancers, higher stage at presentation, nodal involvement, and need for therapies reflecting higher risk biology. |
| doi_str_mv | 10.1016/j.amjsurg.2015.09.001 |
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This study attempts to identify risk factors. Methods A prospectively maintained database was queried to identify patients with a regional recurrence of breast cancer after a first operation for invasive unilateral breast cancer. Patients with regional recurrence were compared with those alive and disease free at 5 years. Results Twenty-one of 1,060 patients (2%) experienced a regional recurrence. Most patients (95%) underwent sentinel lymph node biopsy as their axillary staging. Those with regional recurrences had larger tumors ( P < .001), higher stage disease ( P < .001), more estrogen receptor– and triple-negative breast cancers ( P < .001), and more positive lymph nodes ( P = .007). Mastectomy ( P = .001) and receipt of neoadjuvant and/or chemotherapy ( P < .001) were more common among those with regional recurrences. Conclusions Regional recurrence of breast cancer occurs infrequently. Risk factors include high-risk cancers, higher stage at presentation, nodal involvement, and need for therapies reflecting higher risk biology.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/j.amjsurg.2015.09.001</identifier><identifier>PMID: 26601646</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Biopsy ; Breast cancer ; Breast Neoplasms - pathology ; Breast Neoplasms - therapy ; Cancer therapies ; Chemotherapy ; Dissection ; Female ; Humans ; Lymphatic Metastasis - pathology ; Lymphatic system ; Metastasis ; Middle Aged ; Neoplasm Recurrence, Local - pathology ; Neoplasm Staging ; Patients ; Prospective Studies ; Regional recurrence ; Risk Factors ; Sentinel Lymph Node Biopsy ; Studies ; Surgery ; Tumors ; Ultrasonic imaging</subject><ispartof>The American journal of surgery, 2015-12, Vol.210 (6), p.1155-1161</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Dec 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-48dc1810982d43ac857219b48a31fb1c8dc690a2678a9570a946f90f118616783</citedby><cites>FETCH-LOGICAL-c518t-48dc1810982d43ac857219b48a31fb1c8dc690a2678a9570a946f90f118616783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1746597595?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002,64392,64394,64396,72476</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26601646$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Linnaus, Maria E., M.D</creatorcontrib><creatorcontrib>Dueck, Amylou C., Ph.D</creatorcontrib><creatorcontrib>Kosiorek, Heidi E., M.S</creatorcontrib><creatorcontrib>Gray, Richard J., M.D</creatorcontrib><creatorcontrib>Wasif, Nabil, M.D</creatorcontrib><creatorcontrib>Northfelt, Donald W., M.D</creatorcontrib><creatorcontrib>Anderson, Karen S., M.D., Ph.D</creatorcontrib><creatorcontrib>McCullough, Ann E., M.D</creatorcontrib><creatorcontrib>Wong, William W., M.D</creatorcontrib><creatorcontrib>Halyard, Michele Y., M.D</creatorcontrib><creatorcontrib>Patel, Samir H., M.D</creatorcontrib><creatorcontrib>Pockaj, Barbara A., M.D</creatorcontrib><title>Regional recurrence in the era of sentinel lymph node biopsy</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Abstract Background The incidence of all-location regional recurrence after sentinel lymph node biopsy is not well documented. This study attempts to identify risk factors. Methods A prospectively maintained database was queried to identify patients with a regional recurrence of breast cancer after a first operation for invasive unilateral breast cancer. Patients with regional recurrence were compared with those alive and disease free at 5 years. Results Twenty-one of 1,060 patients (2%) experienced a regional recurrence. Most patients (95%) underwent sentinel lymph node biopsy as their axillary staging. Those with regional recurrences had larger tumors ( P < .001), higher stage disease ( P < .001), more estrogen receptor– and triple-negative breast cancers ( P < .001), and more positive lymph nodes ( P = .007). Mastectomy ( P = .001) and receipt of neoadjuvant and/or chemotherapy ( P < .001) were more common among those with regional recurrences. Conclusions Regional recurrence of breast cancer occurs infrequently. Risk factors include high-risk cancers, higher stage at presentation, nodal involvement, and need for therapies reflecting higher risk biology.</description><subject>Biopsy</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - therapy</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Dissection</subject><subject>Female</subject><subject>Humans</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Lymphatic system</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Staging</subject><subject>Patients</subject><subject>Prospective Studies</subject><subject>Regional recurrence</subject><subject>Risk Factors</subject><subject>Sentinel Lymph Node Biopsy</subject><subject>Studies</subject><subject>Surgery</subject><subject>Tumors</subject><subject>Ultrasonic imaging</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkV2L1TAQhoMo7nH1JygFb7xpnWmTNAFRZPELFgQ_rkNOOt1NbZtj0grn35tyjgp741VI8sw7zDOMPUWoEFC-HCo7DWmNN1UNKCrQFQDeYztUrS5RqeY-2wFAXWqJcMEepTTkKyJvHrKLWsqcweWOvfpCNz7MdiwiuTVGmh0Vfi6WWyoo2iL0RaJ58TONxXicDrfFHDoq9j4c0vExe9DbMdGT83nJvr9_9-3qY3n9-cOnq7fXpROolpKrzqFC0KrueGOdEm2Nes-VbbDfo8vfUoOtZausFi1YzWWvoUdUEvNjc8lenHIPMfxcKS1m8snRONqZwpoMtgI4l5pjRp_fQYewxjzfRnEpdCu0yJQ4US6GlCL15hD9ZOPRIJhNrxnMWa_Z9BrQJsvLdc_O6et-ou5v1R-fGXhzAijr-OUpmuT85rTz2e9iuuD_2-L1nQQ3-tk7O_6gI6V_05hUGzBftx1vK0YBwLUSzW-ilaAZ</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Linnaus, Maria E., M.D</creator><creator>Dueck, Amylou C., Ph.D</creator><creator>Kosiorek, Heidi E., M.S</creator><creator>Gray, Richard J., M.D</creator><creator>Wasif, Nabil, M.D</creator><creator>Northfelt, Donald W., M.D</creator><creator>Anderson, Karen S., M.D., Ph.D</creator><creator>McCullough, Ann E., M.D</creator><creator>Wong, William W., M.D</creator><creator>Halyard, Michele Y., M.D</creator><creator>Patel, Samir H., M.D</creator><creator>Pockaj, Barbara A., M.D</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20151201</creationdate><title>Regional recurrence in the era of sentinel lymph node biopsy</title><author>Linnaus, Maria E., M.D ; Dueck, Amylou C., Ph.D ; Kosiorek, Heidi E., M.S ; Gray, Richard J., M.D ; Wasif, Nabil, M.D ; Northfelt, Donald W., M.D ; Anderson, Karen S., M.D., Ph.D ; McCullough, Ann E., M.D ; Wong, William W., M.D ; Halyard, Michele Y., M.D ; Patel, Samir H., M.D ; Pockaj, Barbara A., M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c518t-48dc1810982d43ac857219b48a31fb1c8dc690a2678a9570a946f90f118616783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Biopsy</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - therapy</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Dissection</topic><topic>Female</topic><topic>Humans</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Lymphatic system</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Staging</topic><topic>Patients</topic><topic>Prospective Studies</topic><topic>Regional recurrence</topic><topic>Risk Factors</topic><topic>Sentinel Lymph Node Biopsy</topic><topic>Studies</topic><topic>Surgery</topic><topic>Tumors</topic><topic>Ultrasonic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Linnaus, Maria E., M.D</creatorcontrib><creatorcontrib>Dueck, Amylou C., Ph.D</creatorcontrib><creatorcontrib>Kosiorek, Heidi E., M.S</creatorcontrib><creatorcontrib>Gray, Richard J., M.D</creatorcontrib><creatorcontrib>Wasif, Nabil, M.D</creatorcontrib><creatorcontrib>Northfelt, Donald W., M.D</creatorcontrib><creatorcontrib>Anderson, Karen S., M.D., Ph.D</creatorcontrib><creatorcontrib>McCullough, Ann E., M.D</creatorcontrib><creatorcontrib>Wong, William W., M.D</creatorcontrib><creatorcontrib>Halyard, Michele Y., M.D</creatorcontrib><creatorcontrib>Patel, Samir H., M.D</creatorcontrib><creatorcontrib>Pockaj, Barbara A., M.D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Linnaus, Maria E., M.D</au><au>Dueck, Amylou C., Ph.D</au><au>Kosiorek, Heidi E., M.S</au><au>Gray, Richard J., M.D</au><au>Wasif, Nabil, M.D</au><au>Northfelt, Donald W., M.D</au><au>Anderson, Karen S., M.D., Ph.D</au><au>McCullough, Ann E., M.D</au><au>Wong, William W., M.D</au><au>Halyard, Michele Y., M.D</au><au>Patel, Samir H., M.D</au><au>Pockaj, Barbara A., M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regional recurrence in the era of sentinel lymph node biopsy</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>210</volume><issue>6</issue><spage>1155</spage><epage>1161</epage><pages>1155-1161</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><abstract>Abstract Background The incidence of all-location regional recurrence after sentinel lymph node biopsy is not well documented. This study attempts to identify risk factors. Methods A prospectively maintained database was queried to identify patients with a regional recurrence of breast cancer after a first operation for invasive unilateral breast cancer. Patients with regional recurrence were compared with those alive and disease free at 5 years. Results Twenty-one of 1,060 patients (2%) experienced a regional recurrence. Most patients (95%) underwent sentinel lymph node biopsy as their axillary staging. Those with regional recurrences had larger tumors ( P < .001), higher stage disease ( P < .001), more estrogen receptor– and triple-negative breast cancers ( P < .001), and more positive lymph nodes ( P = .007). Mastectomy ( P = .001) and receipt of neoadjuvant and/or chemotherapy ( P < .001) were more common among those with regional recurrences. Conclusions Regional recurrence of breast cancer occurs infrequently. Risk factors include high-risk cancers, higher stage at presentation, nodal involvement, and need for therapies reflecting higher risk biology.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26601646</pmid><doi>10.1016/j.amjsurg.2015.09.001</doi><tpages>7</tpages></addata></record> |
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| subjects | Biopsy Breast cancer Breast Neoplasms - pathology Breast Neoplasms - therapy Cancer therapies Chemotherapy Dissection Female Humans Lymphatic Metastasis - pathology Lymphatic system Metastasis Middle Aged Neoplasm Recurrence, Local - pathology Neoplasm Staging Patients Prospective Studies Regional recurrence Risk Factors Sentinel Lymph Node Biopsy Studies Surgery Tumors Ultrasonic imaging |
| title | Regional recurrence in the era of sentinel lymph node biopsy |
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