Autism-Associated Chromatin Regulator Brg1/SmarcA4 Is Required for Synapse Development and Myocyte Enhancer Factor 2-Mediated Synapse Remodeling

Synapse development requires normal neuronal activities and the precise expression of synapse-related genes. Dysregulation of synaptic genes results in neurological diseases such as autism spectrum disorders (ASD). Mutations in genes encoding chromatin-remodeling factor Brg1/SmarcA4 and its associat...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular and cellular biology 2016-01, Vol.36 (1), p.70-83
Hauptverfasser:	Zhang, Zilai, Cao, Mou, Chang, Chia-Wei, Wang, Cindy, Shi, Xuanming, Zhan, Xiaoming, Birnbaum, Shari G., Bezprozvanny, Ilya, Huber, Kimberly M., Wu, Jiang I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autistic Disorder - genetics Autistic Disorder - metabolism Chromatin - metabolism Dendritic Spines - genetics DNA Helicases - genetics DNA Helicases - metabolism Hippocampus - metabolism MEF2 Transcription Factors - genetics MEF2 Transcription Factors - metabolism Mice Nerve Tissue Proteins - metabolism Neurons - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Synapses - metabolism Transcription Factors - genetics Transcription Factors - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!