Preclinical and Preliminary Clinical Evaluation of Genetically Transduced Dermal Tissue Implants for the Sustained Secretion of Erythropoietin and Interferon α

Protein drugs are currently delivered by bolus injection and although treatment frequently is successful, these methods also have major drawbacks, which call for the development of alternative technologies allowing prolonged delivery of these drugs. We developed a new ex vivo gene therapy platform c...

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Veröffentlicht in:	Human gene therapy. Clinical development 2015-12, Vol.26 (4), p.216-227
Hauptverfasser:	Shapir, Nir, Miari, Reem, Blum, Shany, Schwartz, Doron, Chernin, Gil, Neil, Garry A, Afik, Daniel, Panet, Amos
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adult Aged Animals Erythropoietin - blood Erythropoietin - genetics Erythropoietin - metabolism Genetic Therapy - adverse effects Genetic Therapy - methods Humans Interferon-alpha - blood Interferon-alpha - genetics Interferon-alpha - metabolism Male Mice Mice, Inbred NOD Mice, SCID Renal Insufficiency - therapy Skin Transplantation - adverse effects Skin Transplantation - methods
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