Screening for cognitive dysfunction in unipolar depression: Validation and evaluation of objective and subjective tools
Abstract Background Persistent cognitive dysfunction in unipolar depression (UD) contributes to socio-occupational impairment, but there are no feasible methods to screen for and monitor cognitive dysfunction in this patient group. The present study investigated the validity of two new instruments t...
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| Veröffentlicht in: | Journal of affective disorders 2016-01, Vol.190, p.607-615 |
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| creator | Ott, Caroline Vintergaard Bjertrup, Anne Juul Jensen, Johan Høy Ullum, Henrik Sjælland, René Purdon, Scot E Vieta, Eduard Kessing, Lars V Miskowiak, Kamilla W |
| description | Abstract Background Persistent cognitive dysfunction in unipolar depression (UD) contributes to socio-occupational impairment, but there are no feasible methods to screen for and monitor cognitive dysfunction in this patient group. The present study investigated the validity of two new instruments to screen for cognitive dysfunction in UD, and their associations with socio-occupational capacity. Method Participants ( n =53) with UD in partial or full remission and healthy control persons ( n =103) were assessed with two new screening instruments, the Danish translations of the Screen for Cognitive Impairment in Psychiatry (SCIP-D) and Cognitive Complaints in Bipolar Disorder Rating Assessment (COBRA) and with established neuropsychological and self-assessment measures. Depression symptoms and socio-occupational function were rated with the Hamilton Depression Rating Scale and Functional Assessment Short Test respectively. Results The SCIP-D and COBRA were valid for detection of objective and subjective cognitive impairment, respectively. The three parallel SCIP-D forms were equivalent. A combined SCIP-D-COBRA measure showed high sensitivity and good specificity for objective cognitive impairment (91% and 70%, respectively). There was no correlation between subjective and objective measures of cognition. Subjective cognitive difficulties correlated more with socio-occupational impairment ( r =0.7, p |
| doi_str_mv | 10.1016/j.jad.2015.10.059 |
| format | Article |
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The present study investigated the validity of two new instruments to screen for cognitive dysfunction in UD, and their associations with socio-occupational capacity. Method Participants ( n =53) with UD in partial or full remission and healthy control persons ( n =103) were assessed with two new screening instruments, the Danish translations of the Screen for Cognitive Impairment in Psychiatry (SCIP-D) and Cognitive Complaints in Bipolar Disorder Rating Assessment (COBRA) and with established neuropsychological and self-assessment measures. Depression symptoms and socio-occupational function were rated with the Hamilton Depression Rating Scale and Functional Assessment Short Test respectively. Results The SCIP-D and COBRA were valid for detection of objective and subjective cognitive impairment, respectively. The three parallel SCIP-D forms were equivalent. A combined SCIP-D-COBRA measure showed high sensitivity and good specificity for objective cognitive impairment (91% and 70%, respectively). There was no correlation between subjective and objective measures of cognition. Subjective cognitive difficulties correlated more with socio-occupational impairment ( r =0.7, p <0.01) than did objective cognitive difficulties, for which there was a weak correlation with the executive skills domain only ( r =−0.3, p =0.05). Limitations A modest sample size. Conclusions The SCIP-D and COBRA are valid measures of objective and subjective cognitive impairment, respectively, and should ideally be implemented together in the screening for cognitive dysfunction in UD.</description><identifier>ISSN: 0165-0327</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/j.jad.2015.10.059</identifier><identifier>PMID: 26583350</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Assessment ; Case-Control Studies ; Cognition ; Cognition Disorders - complications ; Cognition Disorders - diagnosis ; Depression ; Depressive Disorder - complications ; Depressive Disorder - psychology ; Female ; Humans ; Male ; Mood disorder ; Neuropsychological Tests ; Psychiatry ; Reproducibility of Results ; Screening ; Self-Assessment ; Sensitivity and Specificity ; Socio-occupational function</subject><ispartof>Journal of affective disorders, 2016-01, Vol.190, p.607-615</ispartof><rights>Elsevier B.V.</rights><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-ae1c765e3e233389c3c8aa78c521363857af2bc58002463a8854a739d219f36d3</citedby><cites>FETCH-LOGICAL-c474t-ae1c765e3e233389c3c8aa78c521363857af2bc58002463a8854a739d219f36d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jad.2015.10.059$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26583350$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ott, Caroline Vintergaard</creatorcontrib><creatorcontrib>Bjertrup, Anne Juul</creatorcontrib><creatorcontrib>Jensen, Johan Høy</creatorcontrib><creatorcontrib>Ullum, Henrik</creatorcontrib><creatorcontrib>Sjælland, René</creatorcontrib><creatorcontrib>Purdon, Scot E</creatorcontrib><creatorcontrib>Vieta, Eduard</creatorcontrib><creatorcontrib>Kessing, Lars V</creatorcontrib><creatorcontrib>Miskowiak, Kamilla W</creatorcontrib><title>Screening for cognitive dysfunction in unipolar depression: Validation and evaluation of objective and subjective tools</title><title>Journal of affective disorders</title><addtitle>J Affect Disord</addtitle><description>Abstract Background Persistent cognitive dysfunction in unipolar depression (UD) contributes to socio-occupational impairment, but there are no feasible methods to screen for and monitor cognitive dysfunction in this patient group. The present study investigated the validity of two new instruments to screen for cognitive dysfunction in UD, and their associations with socio-occupational capacity. Method Participants ( n =53) with UD in partial or full remission and healthy control persons ( n =103) were assessed with two new screening instruments, the Danish translations of the Screen for Cognitive Impairment in Psychiatry (SCIP-D) and Cognitive Complaints in Bipolar Disorder Rating Assessment (COBRA) and with established neuropsychological and self-assessment measures. Depression symptoms and socio-occupational function were rated with the Hamilton Depression Rating Scale and Functional Assessment Short Test respectively. Results The SCIP-D and COBRA were valid for detection of objective and subjective cognitive impairment, respectively. The three parallel SCIP-D forms were equivalent. A combined SCIP-D-COBRA measure showed high sensitivity and good specificity for objective cognitive impairment (91% and 70%, respectively). There was no correlation between subjective and objective measures of cognition. Subjective cognitive difficulties correlated more with socio-occupational impairment ( r =0.7, p <0.01) than did objective cognitive difficulties, for which there was a weak correlation with the executive skills domain only ( r =−0.3, p =0.05). Limitations A modest sample size. Conclusions The SCIP-D and COBRA are valid measures of objective and subjective cognitive impairment, respectively, and should ideally be implemented together in the screening for cognitive dysfunction in UD.</description><subject>Adult</subject><subject>Assessment</subject><subject>Case-Control Studies</subject><subject>Cognition</subject><subject>Cognition Disorders - complications</subject><subject>Cognition Disorders - diagnosis</subject><subject>Depression</subject><subject>Depressive Disorder - complications</subject><subject>Depressive Disorder - psychology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Mood disorder</subject><subject>Neuropsychological Tests</subject><subject>Psychiatry</subject><subject>Reproducibility of Results</subject><subject>Screening</subject><subject>Self-Assessment</subject><subject>Sensitivity and Specificity</subject><subject>Socio-occupational function</subject><issn>0165-0327</issn><issn>1573-2517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS0EokPpA7BBXrLJ4J_YTkBCqipokSp10dKt5bFvKgePPdjJoHl7nE7pggUr61yfc6T7XYTeUbKmhMqP43o0bs0IFVWviehfoBUVijdMUPUSrapHNIQzdYLelDISQmSvyGt0wqToOBdkhX7f2gwQfXzAQ8rYpofoJ78H7A5lmKOdfIrYRzxHv0vBZOxgl6GUOv6E703wzjxaTHQY9ibMR5kGnDYj2Meq5a_Mz3JKKZS36NVgQoGzp_cU_fj29e7iqrm-ufx-cX7d2Fa1U2OAWiUFcGCc86633HbGqM4KRrnknVBmYBsrOkJYK7npOtEaxXvHaD9w6fgp-nDs3eX0a4Yy6a0vFkIwEdJcNFWCtFxKyaqVHq02p1IyDHqX_dbkg6ZEL7z1qCtvvfBeRpV3zbx_qp83W3DPib-Aq-Hz0QB1yb2HrIv1EC04nysP7ZL_b_2Xf9I2-OitCT_hAGVMc46Vnqa6ME307XLw5d5UcFKRtPwP1hWmmg</recordid><startdate>20160115</startdate><enddate>20160115</enddate><creator>Ott, Caroline Vintergaard</creator><creator>Bjertrup, Anne Juul</creator><creator>Jensen, Johan Høy</creator><creator>Ullum, Henrik</creator><creator>Sjælland, René</creator><creator>Purdon, Scot E</creator><creator>Vieta, Eduard</creator><creator>Kessing, Lars V</creator><creator>Miskowiak, Kamilla W</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160115</creationdate><title>Screening for cognitive dysfunction in unipolar depression: Validation and evaluation of objective and subjective tools</title><author>Ott, Caroline Vintergaard ; Bjertrup, Anne Juul ; Jensen, Johan Høy ; Ullum, Henrik ; Sjælland, René ; Purdon, Scot E ; Vieta, Eduard ; Kessing, Lars V ; Miskowiak, Kamilla W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-ae1c765e3e233389c3c8aa78c521363857af2bc58002463a8854a739d219f36d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Assessment</topic><topic>Case-Control Studies</topic><topic>Cognition</topic><topic>Cognition Disorders - complications</topic><topic>Cognition Disorders - diagnosis</topic><topic>Depression</topic><topic>Depressive Disorder - complications</topic><topic>Depressive Disorder - psychology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Mood disorder</topic><topic>Neuropsychological Tests</topic><topic>Psychiatry</topic><topic>Reproducibility of Results</topic><topic>Screening</topic><topic>Self-Assessment</topic><topic>Sensitivity and Specificity</topic><topic>Socio-occupational function</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ott, Caroline Vintergaard</creatorcontrib><creatorcontrib>Bjertrup, Anne Juul</creatorcontrib><creatorcontrib>Jensen, Johan Høy</creatorcontrib><creatorcontrib>Ullum, Henrik</creatorcontrib><creatorcontrib>Sjælland, René</creatorcontrib><creatorcontrib>Purdon, Scot E</creatorcontrib><creatorcontrib>Vieta, Eduard</creatorcontrib><creatorcontrib>Kessing, Lars V</creatorcontrib><creatorcontrib>Miskowiak, Kamilla W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ott, Caroline Vintergaard</au><au>Bjertrup, Anne Juul</au><au>Jensen, Johan Høy</au><au>Ullum, Henrik</au><au>Sjælland, René</au><au>Purdon, Scot E</au><au>Vieta, Eduard</au><au>Kessing, Lars V</au><au>Miskowiak, Kamilla W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Screening for cognitive dysfunction in unipolar depression: Validation and evaluation of objective and subjective tools</atitle><jtitle>Journal of affective disorders</jtitle><addtitle>J Affect Disord</addtitle><date>2016-01-15</date><risdate>2016</risdate><volume>190</volume><spage>607</spage><epage>615</epage><pages>607-615</pages><issn>0165-0327</issn><eissn>1573-2517</eissn><abstract>Abstract Background Persistent cognitive dysfunction in unipolar depression (UD) contributes to socio-occupational impairment, but there are no feasible methods to screen for and monitor cognitive dysfunction in this patient group. The present study investigated the validity of two new instruments to screen for cognitive dysfunction in UD, and their associations with socio-occupational capacity. Method Participants ( n =53) with UD in partial or full remission and healthy control persons ( n =103) were assessed with two new screening instruments, the Danish translations of the Screen for Cognitive Impairment in Psychiatry (SCIP-D) and Cognitive Complaints in Bipolar Disorder Rating Assessment (COBRA) and with established neuropsychological and self-assessment measures. Depression symptoms and socio-occupational function were rated with the Hamilton Depression Rating Scale and Functional Assessment Short Test respectively. Results The SCIP-D and COBRA were valid for detection of objective and subjective cognitive impairment, respectively. The three parallel SCIP-D forms were equivalent. A combined SCIP-D-COBRA measure showed high sensitivity and good specificity for objective cognitive impairment (91% and 70%, respectively). There was no correlation between subjective and objective measures of cognition. Subjective cognitive difficulties correlated more with socio-occupational impairment ( r =0.7, p <0.01) than did objective cognitive difficulties, for which there was a weak correlation with the executive skills domain only ( r =−0.3, p =0.05). Limitations A modest sample size. Conclusions The SCIP-D and COBRA are valid measures of objective and subjective cognitive impairment, respectively, and should ideally be implemented together in the screening for cognitive dysfunction in UD.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26583350</pmid><doi>10.1016/j.jad.2015.10.059</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Assessment Case-Control Studies Cognition Cognition Disorders - complications Cognition Disorders - diagnosis Depression Depressive Disorder - complications Depressive Disorder - psychology Female Humans Male Mood disorder Neuropsychological Tests Psychiatry Reproducibility of Results Screening Self-Assessment Sensitivity and Specificity Socio-occupational function |
| title | Screening for cognitive dysfunction in unipolar depression: Validation and evaluation of objective and subjective tools |
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