FOXM1 targets XIAP and Survivin to modulate breast cancer survival and chemoresistance

Drug resistance is a major hurdle for successful treatment of breast cancer, the leading cause of deaths in women throughout the world. The FOXM1 transcription factor is a potent oncogene that transcriptionally regulates a wide range of target genes involved in DNA repair, metastasis, cell invasion,...

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Veröffentlicht in:	Cellular signalling 2015-12, Vol.27 (12), p.2496-2505
Hauptverfasser:	Nestal de Moraes, Gabriela, Delbue, Deborah, Silva, Karina L., Robaina, Marcela Cristina, Khongkow, Pasarat, Gomes, Ana R., Zona, Stefania, Crocamo, Susanne, Mencalha, André Luiz, Magalhães, Lídia M., Lam, Eric W.-F., Maia, Raquel C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - pharmacology Base Sequence Binding Sites Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - mortality Cell Survival Doxorubicin - pharmacology Drug resistance Drug Resistance, Neoplasm Female Forkhead Box Protein M1 Forkhead Transcription Factors - physiology FOXM1 Gene Expression Gene Expression Regulation, Neoplastic Humans Inhibitor of Apoptosis Proteins - genetics Inhibitor of Apoptosis Proteins - metabolism Kaplan-Meier Estimate MCF-7 Cells Middle Aged Prognosis Promoter Regions, Genetic Protein Binding Survivin Taxoids - pharmacology X-Linked Inhibitor of Apoptosis Protein - genetics X-Linked Inhibitor of Apoptosis Protein - metabolism XIAP
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