Novel phosphorylation of PPARγ ameliorates obesity-induced adipose tissue inflammation and improves insulin sensitivity

Chronic inflammation in adipose tissue is highly associated with insulin resistance. Herein, we demonstrate that a novel modification of PPARγ is strongly associated with inflammatory responses in adipose tissue. c-Src kinase directly phosphorylated PPARγ at Tyr78, and this process was reversed by p...

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Veröffentlicht in:	Cellular signalling 2015-12, Vol.27 (12), p.2488-2495
Hauptverfasser:	Choi, Sunsil, Jung, Ji-Eun, Yang, Yong Ryoul, Kim, Eun-Sun, Jang, Hyun-Jun, Kim, Eung-Kyun, Kim, Il Shin, Lee, Joo-Young, Kim, Joong Kwan, Seo, Jeong Kon, Kim, Jung-Min, Park, Jiyoung, Suh, Pann-Ghill, Choi, Jang Hyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - immunology Adipose Tissue - metabolism Amino Acid Sequence Animals c-Src Chemokines - genetics Chemokines - metabolism Chemokines - secretion Gene Expression Regulation HEK293 Cells Humans Inflammation Insulin Resistance Male Metabolic disorders Mice Mice, Inbred C57BL Obesity - immunology Obesity - metabolism Phosphorylation PPAR gamma - metabolism PPARγ Protein Processing, Post-Translational Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism PTP-1B RAW 264.7 Cells src-Family Kinases - physiology
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